Glutathione-S-transferase P1 as a risk factor for Egyptian patients with chronic myeloid leukemia

Hamed, Nahla A M; Ghallab, Omar; Elneily, Dalia

doi:10.4103/1110-1067.186408

Cited by 5 publications

(3 citation statements)

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“…Still, this finding needs to be confirmed in studies with larger sample sizes, as the number of CML patients in advanced phase was very small in our study. We showed no significant differences in Hb, platelet count, and WBC count between CML patients with and without the GST null polymorphisms and this is consistent with previous studies involving Egyptian and Indian populations [34,35].…”

Section: Discussionsupporting

confidence: 92%

“…The present study showed that the association between CML and GSTT1 and GSTM1 null polymorphisms was not affected by the gender and age of patients, which is consistent with previous reports [34,35]. However, our results indicated a significantly lower frequency of the GSTM1 null genotype in advanced-phase CML patients compared to chronic-phase patients.…”

Section: Discussionsupporting

confidence: 92%

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Age- and gender-independent association of glutathione S-transferase null polymorphisms with chronic myeloid leukemia

Muddathir

Abdallah

Khabour

et al. 2019

Bosn J of Basic Med Sci

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The glutathione S-transferase (GST) genes encode enzymes that mediate the detoxification of xenobiotics by catalyzing the conjugation of glutathione (GSH) to xenobiotic substrates. The aim of the current study is to investigate the association between GSTT1 and GSTM1 polymorphisms and chronic myeloid leukemia (CML) among Sudanese patients. Patients with CML (n = 115) were recruited to the study from the Radiation and Isotope Centre Khartoum (RICK)-Sudan. Healthy individuals (n = 104) were included as controls. Genotyping of GSTT1 and GSTM1 polymorphisms was performed using multiplex PCR. Null deletions in the GSTT1 and GSTM1 genes are common in the Sudanese population (control group), with frequencies of 33.9% and 38.2%, respectively. The frequencies of GSTT1 (OR: 3.25, 95% CI: 1.87–5.65, p < 0.001) and GSTM1 (OR: 2.14, 95% CI: 1.25–3.67, p < 0.005) null genotypes were significantly higher in CML patients vs. controls. The distribution of GSTT1 and GSTM1 null polymorphisms was not different between male and female (p > 0.01) and young and old CML patients (p > 0.05). Hematological parameters were not affected by null polymorphisms in the patient group (p > 0.05). In addition, the frequency of GSTM1 null polymorphism was lower in advanced-phase CML patients compared to chronic-phase patients (p < 0.05). The GSTT1 and GSTM1 null polymorphisms are associated with CML among Sudanese patients, independently of their age and gender.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Age- and gender-independent association of glutathione S-transferase null polymorphisms with chronic myeloid leukemia

Muddathir

Abdallah

Khabour

et al. 2019

Bosn J of Basic Med Sci

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“…The ABCB1 gene which is one of the members of the ABC superfamily, encodes for a transmembrane glycoprotein (P-gp, MDR1) which is able of pumping IM out of the tumor cell. Its overexpression may confer the resistance of IM in cell lines model and at the clinical level 34 . Our results did not discover any significant differences in mRNA expression of ABCBI gene between IM good or bad responders enrolled in this work.…”

Section: Discussionmentioning

confidence: 99%

A Study to Explore the Role of IDH1 (R132) Mutation on Imatinib Toxicity and Effect of ABCG2/OCT1 Expression on N-Desmethyl Imatinib Plasma Level in Egyptian Chronic Myeloid Leukemia Patients

et al. 2023

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Imatinib mesylate (IM) is the gold standard for treatment of Chronic Myeloid Leukemia (CML). This study aimed to gain more knowledge of the altered PK, pharmacogenetic factors, and gene expression leading to variable IM levels. Fifty patients with chronic phase-CML were enrolled in this study and divided as 25 responders and 25 non-responders (patients are directly recruited after response assessment). HPLC/MS/MS was used to determine trough and peak concentration of imatinib and N-desmethyl imatinib in the blood. PCR-RFLP technique was used to detect IDH1 gene mutation (R132). The median value of IM trough level was significantly higher, the P/T ratio was significantly lower and the α-1-acid glycoprotein (AGP) was significantly higher among responders compared to non-responders (P=0.007, 0.009 and 0.048, respectively). Higher N-desmethyl imatinib peak plasma concentration was observed with low mRNA expression of ABCG2 and OCT1 (P=0.01 and 0.037, respectively). IDH1 R132 gene mutation was associated with a significant increase in toxicities (P=0.028). In conclusion, IM trough level, P/T ratio and AGP was significantly higher in responders. In addition, ABCG2 and OCT1 gene expression may affect the interindividual PK variation. Although a prospective study with a larger patient population is necessary to validate these findings. IDH1 mutation is a predictor of increased toxicity with IM treatment.

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The Agglutinin of Common Nettle (Urtica dioica L.) Plant Effects on Gene Expression Related to Apoptosis of Human Acute Myeloid Leukemia Cell Line

et al. 2021

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Glutathione-S-transferase P1 as a risk factor for Egyptian patients with chronic myeloid leukemia

Cited by 5 publications

References 0 publications

Age- and gender-independent association of glutathione S-transferase null polymorphisms with chronic myeloid leukemia

Age- and gender-independent association of glutathione S-transferase null polymorphisms with chronic myeloid leukemia

A Study to Explore the Role of IDH1 (R132) Mutation on Imatinib Toxicity and Effect of ABCG2/OCT1 Expression on N-Desmethyl Imatinib Plasma Level in Egyptian Chronic Myeloid Leukemia Patients

The Agglutinin of Common Nettle (Urtica dioica L.) Plant Effects on Gene Expression Related to Apoptosis of Human Acute Myeloid Leukemia Cell Line

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