A Study to Explore the Role of IDH1 (R132) Mutation on Imatinib Toxicity and Effect of ABCG2/OCT1 Expression on N-Desmethyl Imatinib Plasma Level in Egyptian Chronic Myeloid Leukemia Patients
Abstract:Imatinib mesylate (IM) is the gold standard for treatment of Chronic Myeloid
Leukemia (CML). This study aimed to gain more knowledge of the altered PK,
pharmacogenetic factors, and gene expression leading to variable IM levels.
Fifty patients with chronic phase-CML were enrolled in this study and divided as
25 responders and 25 non-responders (patients are directly recruited after
response assessment). HPLC/MS/M… Show more
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