Glutathione S-transferase Mu (GSTM1) null genotype in relation to gender, age and smoking status in a healthy Brazilian population

Guembarovski, Roberta Losi; d’Arce, Luciana Paula Grégio; Cólus, Ilce Mara de Syllos

doi:10.1590/s1415-47572002000400001

Cited by 9 publications

(4 citation statements)

References 23 publications

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“…The correlation between the GSTM1 null genotype and gastric cancer appeared to be more consistent [22,25,27,28,30,53] . On the other hand, other authors failed to demonstrate any statistically significant difference in the GSTM1 polymorphism distribution of gastric cancer patients and controls [24,26,32,36,52,55,56] . Several case-control studies also failed to find a significant association between the CYP2E1/PstI polymorphism and gastric cancer [23,24,26,34] .…”

Section: Discussionmentioning

confidence: 94%

“…Although studies of the GSTT1 and GSTM1 polymorphisms were performed previously, their association with gastric cancer susceptibility has not been established. Most of them showed no association between the GSTT1 null genotype and risk for gastric cancer [25,32,36,52,53] . However, two others suggested that the GSTT1 null genotype might confer an increased risk for gastric cancer [39,54] .…”

Section: Discussionmentioning

confidence: 99%

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GSTT1,GSTM1andCYP2E1genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population

Colombo

Rossit²,

Caetano³

et al. 2004

WJG

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AIM:To test the hypothesis that, in the Southeastern Brazilian population, the GSTT1, GSTM1 and CYP2E1 polymorphisms and putative risk factors are associated with an increased risk for gastric cancer. METHODS:We conducted a study on 100 cases of gastric cancer (GC), 100 cases of chronic gastritis (CG), and 150 controls (C). Deletion of the GSTT1 and GSTM1 genes was assessed by multiplex PCR. CYP2E1/PstI genotyping was performed using a PCR-RFLP assay. RESULTS:No relationship between GSTT1/GSTM1 deletion and the c1/c2 genotype of CYP2E1 was observed among the three groups. However, a significant difference between CG and C was observed, due to a greater number of GSTT1/GSTM1 positive genotypes in the CG group. The GSTT1 null genotype occurred more frequently in Negroid subjects, and the GSTM1 null genotype in Caucasians, while the GSTM1 positive genotype was observed mainly in individuals with chronic gastritis infected with H pylori. CONCLUSION:Our findings indicate that there is no obvious relationship between the GSTT1, GSTM1 and CYP2E1 polymorphisms and gastric cancer.Colombo J, Rossit ARB, Caetano A, Borim AA, Wornrath D, Silva AE. GSTT1, GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

GSTT1,GSTM1andCYP2E1genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population

Colombo

Rossit²,

Caetano³

et al. 2004

WJG

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“…This has been evidenced by the recent meta-analysis of Benhamou et al [10] who showed the GSTM1 deletion carries only a small risk of lung cancer. Second, the majority of studies compared complete absence of GSTM1 with carriers of one or two copies of the gene that can be analysed by straightforward genotyping techniques [27,28]. It is, however, possible to determine the number of GSTM1 and GSTT1 alleles [29,30] and there is evidence that GSTT1 allele number is an important modifier of cancer risk as opposed to a simplified comparison between absence and presence of this gene [30].…”

Section: Discussionmentioning

confidence: 99%

Glutathione S-transferase variants and hypertension

Delles

Padmanabhan²,

Lee³

et al. 2008

Journal of Hypertension

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“…Other studies involving genes of xenobiotic metabolism have been performed in order to describe the frequency of the mutant alleles and genotypes in different healthy populations ( Garte et al , 2001 ; Gaspar et al , 2002 ; Menoyo et al , 2006 ). Some studies carried out in the Brazilian population described mutant allele and genotype frequencies in several regions ( Arruda et al , 1998 ; Gattás and Soares Viera, 2000; Gaspar et al , 2002 ; Losi-Guembarovski et al , 2002 ; Rossini et al , 2002 ; Amorim et al , 2004 ; Gattás et al , 2004; Hatagima et al , 2004 ; Kvitko et al , 2006 ; Rossini et al , 2006 ).…”

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confidence: 99%

Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants

et al. 2009

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Individual variability in xenobiotic metabolism has been associated with susceptibility to developing complex diseases. Genes involved in xenobiotic metabolism have been evaluated in association studies; the difficulty of obtaining accurate gene frequencies in mixed populations makes interpretation of the results difficult. We sought to estimate population parameters for the cytochrome P450 and glutathione S-transferase gene families, thus contributing to studies using these genes as markers. We describe the frequencies of six genes (CYP1A1, CYP2D6, CYP2E1, GSTM1, GSTT1, and GSTP1) and estimate population parameters in 115 Euro-descendants and 196 Afro-descendants from Curitiba, South of Brazil. PCR-based methods were used for genotyping, and statistical analysis were performed by AMOVA with ARLEQUIN software. The mutant allele frequencies in the Afro-descendants and Euro-descendants, respectively, were: CYP1A1*2A = 30.1% and 15.2%; CYP2D6*4 = 14.5% and 21.5%; CYP2E1*5B = 7.9% and 5%; GSTP1*B = 37.8% and 28.3%. The null genotype frequencies were: GSTM1*0 = 36.8% and 46.1%; GSTT1*0 = 24.2% and 17.4%.Key words: CYP, GST, population study. Genetic marker studies assessing individual backgrounds from specific populations can provide information on gene flow, evolutionary history, and population dispersions, and can also help in the prediction of risks for particular diseases. Based on these studies, pharmacogenetic data have shown significant inter-and intra-population differences in the metabolism, efficiencies, and toxicities of several types of drugs. These findings have important implications for the management and treatment of human diseases (Kittles and Weiss, 2003).Many different enzyme families are involved in xenobiotic metabolism, including cytochrome P450 (CYPs) in phase I, as well as glutathione S-transferases (GSTs) and N-acetyl-transferases (NATs) in phase II (Autrup, 2000). Several genes of the CYP family have been studied in many populations (e.g., Europeans, Africans, Asians, and their mixed descendants) in case-control studies of complex diseases. With regard to cancers, these studies focus primarily on lung, breast, and head and neck tumors (Olshan et al.,

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Glutathione S-transferase Mu (GSTM1) null genotype in relation to gender, age and smoking status in a healthy Brazilian population

Cited by 9 publications

References 23 publications

GSTT1,GSTM1andCYP2E1genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population

GSTT1,GSTM1andCYP2E1genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population

Glutathione S-transferase variants and hypertension

Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants

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