Glutathione S-Transferase M1 (GSTM1) and T1 (GSTT1) Polymorphisms in a Brazilian Mixed Population

Hatagima, Ana; Marques, Christiane F.S.; Krieger, Henrique; Feitosa, Mary F.

doi:10.1353/hub.2005.0018

Cited by 11 publications

(5 citation statements)

References 17 publications

(21 reference statements)

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“…GSTM1 null genotype are not uniformly distributed among diverse population, but an ethnic and geographic basis of distribution was suggested [10,18]. The prevalence of individuals not expressing the GSTM1 enzyme due to a homozygous gene deletion is reportedly higher in Europeans and Asians, as compared to Africans [1].…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Three Distinct Arab Populations

et al. 2011

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Abstract. Deletion polymorphisms for the glutathione S-transferase (GST) gene are associated with increased risk of cancer, and are implicated in detoxifying mutagenic electrophilic compounds. GST Polymorphic variants were reported for different populations. The aim of this study was to investigate the frequencies of GSTM1 and GSTT1 null genotypes among Bahraini, Lebanese and Tunisian Arabs. GST genotyping was done by multiplex PCR-based methods. Study subjects comprised 167 Bahrainis, 141 Lebanese and 186 Tunisians unrelated healthy individuals. GSTM1 deletion homozygosity of 49.7%, 52.5% and 63.4% were recorded for Bahraini, Lebanese and Tunisians, respectively. Among Bahrainis, the prevalence of GSTT1 null homozygotes was 28.7%, while in higher rates were seen in Lebanese (37.6%) and Tunisians (37.1%). Our results indicate that there are no major differences in allelic distribution of GSTM1 and GSTT1 genes between the three Arab populations investigated except between Bahrainis and Tunisians regarding the allelic distribution of GSTM1 gene (P = 0.013). Combined analysis of both genes revealed that 14.4% of Bahrainis, 16.3% of Lebanese and 21.0% of Tunisians harbor the deleted genotype of both genes. This is the first study that addresses GST gene polymorphism in Bahraini and Lebanese Arabs, and will help genetic studies on the association of GSTM1 and GSTT1 polymorphisms with disease risks and drug effects in Arab populations.

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Section: Discussionmentioning

confidence: 99%

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Three Distinct Arab Populations

et al. 2011

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“…Brazilians form one of the most heterogeneous populations of the world, as a result of the mixture of different ethnic groups that occurred throughout the colonization of Brazil since the year 1500 (Carvalho-Silva et al, 2001). The genotype frequency distribution of one region depends on the proportion of each ethnic group, which may vary in different regions of the country (Carvalho-Silva et al, 2001;Hatagima et al, 2004). The above considerations emphasize the importance of new casecontrol studies in different populations, in order to try to elucidate the true role of GST polymorphisms in the risk of developing cancer.…”

Section: Discussionmentioning

confidence: 99%

Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro

Coutinho

Sandim²,

Oliveira³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. The glutathione S-transferases (GSTs), a family of phase II isozymes, detoxify several carcinogens. Genetic variations in GSTs have been associated with increased risk for cancer due to a heritable deficiency in detoxification pathways for environmental carcinogens. Conflicting findings have been reported about the association between constitutive GST polymorphisms and gliomas in different populations. The present case-control study examined 78 patients with primary glioma and 347 controls from Rio de Janeiro. DNA was isolated from whole blood, and four genetic polymorphisms (GSTM1, GSTM3, GSTT1, and GSTP1) were determined by PCR-RFLP. The distributions of the genotypic frequencies of these polymorphisms did not differ significantly between cases and controls and were as expected by Hardy-Weinberg equilibrium (P > 0.05). Risk analysis did not show an association between GSTs and primary glioma, suggesting that these polymorphisms do not influence the risk of primary glioma, at least in this population in Rio de Janeiro, Brazil.

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“…These differences show that GST genotype frequencies are distributed populationwise according to the various ethnic and geographical patterns (Garte et al , 2001; Hatagima et al , 2004). In our sample, the frequencies of GSTM1 and GSTT1 null genotypes were 0.361 and 0.331 respectively, whereas the frequency of individuals lacking both genes was 0.143 (Table 1).…”

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confidence: 99%

Polymorphisms of cytochrome P450 1A1, glutathione s-transferases M1 and T1 genes in ouangolodougou (Northern Ivory Coast)

Santovito

Burgarello²,

Cervella

et al. 2010

Genet. Mol. Biol.

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In this study, the frequencies of CYP1A1, GSTM1, and GSTT1 gene polymorphisms were determined in 133 healthy individuals from Ouangolodougou, a small rural town situated in the north of the Ivory Coast. As appeared in several published studies, ethnic differences in these frequencies have been found to play an important role in the metabolism of a relevant number of human carcinogens. In the studied sample, the frequencies of Ile/Ile (wild type), Ile/Val (heterozygous variant), and Val/Val (homozygous variant) CYP1A1 genotypes were 0.271, 0.692, and 0.037, respectively. Frequencies of GSTM1 and GSTT1 null genotypes were 0.361 and 0.331, respectively. No significant differences were noted between men and women. In contrast to published data for Africans, CYP1A1 *Val Allele frequency (0.383) was significantly high (p < 0.001) in this specific population. For the GSTT1 null genotype, no differences were found between the studied and other African populations, the contrary to what occurred for the GSTM1 null genotype in relation to Gambia and Egypt.

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Glutathione S-Transferase M1 (GSTM1) and T1 (GSTT1) Polymorphisms in a Brazilian Mixed Population

Cited by 11 publications

References 17 publications

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Three Distinct Arab Populations

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Three Distinct Arab Populations

Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro

Polymorphisms of cytochrome P450 1A1, glutathione s-transferases M1 and T1 genes in ouangolodougou (Northern Ivory Coast)

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