Glutathione S transferase M1 and T1 genetic polymorphisms are related to the risk of primary open-angle glaucoma: a study in a Turkish population

Abstract

Background: Genetic factors and oxidative damage have been shown to have a role in the development of primary open angle glaucoma (POAG). Aim: To determine the effects of genetic polymorphisms of glutathione S transferase (GST)M1 and GSTT1 on the risk of POAG in a Turkish population. Methods: Using a multiplex polymerase chain reaction (PCR), GSTM1 and GSTT1 gene polymorphisms were analysed in 144 patients with POAG and in 121 otherwise healthy controls of similar age. Results: The GSTM1 positive genotype and the GSTT1 null genotype had an increased risk of developing POAG (p,0.001, OR 2.93, 95% CI 1.66 to 5.20 and OR 4.25, 95% CI 2.30 to 7.80, respectively). The risk of glaucoma also increased significantly in subjects with a combination of GSTM1 positive and GSTT1 null genotypes (p,0.001, OR 3.46, 95% CI 1.64 to 7.38). Conclusion: The GSTM1 positive genotype and GSTT1 null genotype or the combination of both may be associated with the increased risk of development of POAG in the Turkish population.

GSTM1 polymorphism in patients with primary open-angle glaucoma

“…The present study found a higher frequency of the GSTM1 null genotype in the control group (68%) than in the glaucoma group (44%), and our data corroborate those of Unal et al (2007), in which a higher frequency of the GSTM1 null genotype was found in the control group (45%) than in the glaucoma group (21.5%). Unal et al (2007) analyzed 144 patients with POAG and 121 controls implementing the sequence of primers used in our study. Other studies, such as that of Abu-Amero (2008), have analyzed the probable connection between smoking and POAG and, similar to the outcome our study, found no significant relationship.…”

“…In addition, some studies have emphasized the association between GST polymorphisms and risk of eye diseases, including cataracts, senile macular degeneration, and glaucoma (Unal et al, 2007). The present study found a higher frequency of the GSTM1 null genotype in the control group (68%) than in the glaucoma group (44%), and our data corroborate those of Unal et al (2007), in which a higher frequency of the GSTM1 null genotype was found in the control group (45%) than in the glaucoma group (21.5%). Unal et al (2007) analyzed 144 patients with POAG and 121 controls implementing the sequence of primers used in our study.…”

Association between primary open angle glaucoma and genetic polymorphisms GSTM1/GSTT1 in patients from Goiânia Central-West Region of Brazil

“…Several studies identified an association between POAG and glutathione S-transferase (GST) polymorphisms (Juronen et al, 2000;Yildirim et al, 2005;Ünal et al, 2007;Rocha et al, 2011). GSTs are found in a variety of ocular structures including the aqueous humor, ciliary body, and crystalline lens.…”

Bibliometric network analysis of glaucoma

“…GSTT1 has been shown to be polymorphically distributed. Studies have shown that the GSTT1*0 allele corresponds to a total or partial deletion of the gene, causing deficiency in enzymatic activity and GSTT1 null genotype may be associated with increased risk of development of POAG in the Turkish (Unal et al, 2007), Egyptian (Rasool et al, 2010), Arab (Abu-Amero et al, 2009), and Pakistani populations.…”