Glutathione S-transferase genes and the risk of recurrent miscarriage in Italian women

GSTA1 gene variation associated with gestational hypertension and its involvement in pregnancy-related pathogenic conditions

“…No studies have investigated whether genetic variation associated with alterations of GSTA1 gene expression or function could increase the risk of hypertension in pregnant women. However, in 2012 our previous investigation of recurrent miscarriage indicated that GSTA1 genetic variation could be a significant risk factors in the etiology of recurrent miscarriage, indicating GSTA1 as a potential risk locus for other pregnancy-induced pathologic conditions [19].…”

Glutathione S-transferase A1 polymorphism and the risk of recurrent spontaneous abortion in Chinese Han population

“…The GSTA1 enzymes have the ability to protect cells from reactive oxygen species, products of peroxidation and also play a role in the metabolism of polycyclic aromatic hydrocarbons, which are dangerous air pollutants [14]. There was study suggest that the genetic variant of GSTA1 gene, which is GSTA1 −69C/T polymorphism (rs3957357) has significant association with the risk of RSA in Italian women with RSA [15].…”

Explorative genetic association study of GSTT2B copy number variant in complex disease risks

“…The diagnoses were made in accordance with: the Global Initiative on Asthma's criteria (GINA) for asthma; a physician's diagnosis and the use of anti-hypertensive drugs for EH; NINCDS-ADRDA criteria and a Mini Mental State Examination (MMSE) score for AD; medical history, the use of thyroid medication and a physical examination for hypothyroidism; the American College of Obstetrics and Gynecologists' criteria for RM; and a physician's diagnosis, positivity to Prick and Rast tests and the use of anti-allergic treatments for AR. Further information about recruitment and exclusion/inclusion criteria have been reported in our previous studies (Piacentini et al, , 2013aPolimanti et al, 2011Polimanti et al, , 2012. San Giovanni Calibita Fatebenefratelli Isola Tiberina Hospital and the Civil Hospital of Tricarico Bioethics Committees approved the study and written informed consent was obtained from all individuals.…”

“…Many of these studies have focused on genes coding for the Glutathione S-transferase (GST) enzymes. GSTs are the main phase II enzymes involved in cellular detoxification (Frova, 2006;Polimanti et al, 2011Polimanti et al, , 2012Piacentini et al, 2012Piacentini et al, , 2013aPiacentini et al, , 2014.…”