Glutathione-responsive disassembly of disulfide dicyanine for tumor imaging with reduction in background signal intensity

Mo, Shanyan; Zhang, Xiaoting; Hameed, Sadaf; Zhou, Yiming; Dai, Zhifei

doi:10.7150/thno.39673

Cited by 33 publications

(25 citation statements)

References 45 publications

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“… 209 Disulfide-containing dye molecules were employed to quantify cytosolic delivery of biotherapeutics, 211 and also for the imaging of tumor environments with improved signal-to-noise ratios. 212 Disulfide moieties are able to be included in many types of polymer nanoparticles. 213 − 215 For example, Zhong et al .…”

Section: Redox (Glutathione/ros)mentioning

confidence: 99%

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

2021

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Materials that respond to endogenous stimuli are being leveraged to enhance spatiotemporal control in a range of biomedical applications from drug delivery to diagnostic tools. The design of materials that undergo morphological or chemical changes in response to specific biological cues or pathologies will be an important area of research for improving efficacies of existing therapies and imaging agents, while also being promising for developing personalized theranostic systems. Internal stimuli-responsive systems can be engineered across length scales from nanometers to macroscopic and can respond to endogenous signals such as enzymes, pH, glucose, ATP, hypoxia, redox signals, and nucleic acids by incorporating synthetic bio-inspired moieties or natural building blocks. This Review will summarize response mechanisms and fabrication strategies used in internal stimuli-responsive materials with a focus on drug delivery and imaging for a broad range of pathologies, including cancer, diabetes, vascular disorders, inflammation, and microbial infections. We will also discuss observed challenges, future research directions, and clinical translation aspects of these responsive materials.

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Section: Redox (Glutathione/ros)mentioning

confidence: 99%

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

2021

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“…However, external stimuli (e.g., light) are usually used to trigger the release of payload, which may not be always practical or convenient for use under conditions lack of relevant clinic settings or incompatible with the stimuli (e.g., limited penetration depth of light for tumors deeply trapped in viscera or other important tissues). The design of hybrid nanovesicles that are responsive to internal pathological features of tumors (such as hypoxia 39 , high glutathione (GSH) 40 - 43 , acid microenvironment 44 - 50 , elevated level of reactive oxygen species (ROS) 51 - 55 , high glucose 15 level etc.) offers a promising route to overcome the limitations of photo-based therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Tang

et al. 2020

Theranostics

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Rationale: Nanoscale vehicles responsive to abnormal variation in tumor environment are promising for use in targeted delivery of therapeutic drugs specifically to tumor sites. Herein, we report the design and fabrication of self-accelerating H 2 O 2 -responsive plasmonic gold nanovesicles (GVs) encapsulated with tirapazamine (TPZ) and glucose oxidase (GOx) for synergistic chemo/starving therapy of cancers. Methods: Gold nanoparticles were modified with H 2 O 2 -responsive amphiphilic block copolymer PEG 45 - b -PABE 330 by ligand exchange. The TPZ and GOx loaded GVs (TG-GVs) were prepared through the self-assembly of PEG 45 - b -PABE 330 -grafted nanoparticles together with TPZ and GOx by solvent displacement method. Results: In response to H 2 O 2 in tumor, the TG-GVs dissociate to release the payloads that are, otherwise, retained inside the vesicles for days without noticeable leakage. The released GOx enzymes catalyze the oxidation of glucose by oxygen in the tumor tissue to enhance the degree of hypoxia that subsequently triggers the reduction of hypoxia-activated pro-drug TPZ into highly toxic free radicals. The H 2 O 2 generated in the GOx-catalyzed reaction also accelerate the dissociation of vesicles and hence the release rate of the cargoes in tumors. The drug-loaded GVs exhibit superior tumor inhibition efficacy in 4T1 tumor-bearing mice owing to the synergistic effect of chemo/starvation therapy, in addition to their use as contrast agents for computed tomography imaging of tumors. Conclusion: This nanoplatform may find application in managing tumors deeply trapped in viscera or other important tissues that are not compatible with external stimulus (e.g. light).

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“…Internal stimuli, such as low pH, hypoxia, ROS, intracellular thiols and overexpressed enzymes, are inhered in tumor cells or tumor microenvironment while external stimuli including photo-irradiation, temperature etc. are applied factitiously [ 26 ]. The introduction of prodrug strategy to cyanine-chemotherapeutic agent conjugate via a cleavable linker has turned it into stimuli-responsive theranostic agent which can not only exert controllable chemotherapeutic effect but also simultaneously monitor its biodistribution and activation in a spatiotemporal manner.…”

Section: Chemotherapymentioning

confidence: 99%

Cyanine conjugates in cancer theranostics

Yang

Zhou

Yue

et al. 2021

Bioactive Materials

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Cyanine is a meritorious fluorogenic core for the construction of fluorescent probes and its phototherapeutic potential has been enthusiastically explored as well. Alternatively, the covalent conjugation of cyanine with other potent therapeutic agents not only boosts its therapeutic efficacy but also broadens its therapeutic modality. Herein, we summarize miscellaneous cyanine–therapeutic agent conjugates in cancer theranostics from literature published between 2014 and 2020. The application scenarios of such theranostic cyanine conjugates covered common cancer therapeutic modalities, including chemotherapy, phototherapy and targeted therapy. Besides, cyanine conjugates that serve as nanocarriers for drug delivery are introduced as well. In an additional section, we analyze the potential of these conjugates for clinical translation. Overall, this review is aimed to stimulate research interest in exploring unattempted therapeutic agents and novel conjugation strategies and hopefully, accelerate clinical translation in this field.

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Glutathione-responsive disassembly of disulfide dicyanine for tumor imaging with reduction in background signal intensity

Cited by 33 publications

References 45 publications

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Cyanine conjugates in cancer theranostics

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Glutathione-responsive disassembly of disulfide dicyanine for tumor imaging with reduction in background signal intensity

Cited by 33 publications

References 45 publications

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

Self-accelerating H2O2-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Cyanine conjugates in cancer theranostics

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Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors