Glutathione Reductase, Selenium-Dependent Glutathione Peroxidase, Glutathione Levels, and Lipid Peroxidation in Freshwater Bivalves,Unio tumidus,as Biomarkers of Aquatic Contamination in Field Studies

Cossu, Costanza; Doyotte, A; Jacquin, M.C.; Babut, Marc; Exinger, A.; Vasseur, Paule

doi:10.1006/eesa.1997.1582

Cited by 227 publications

(92 citation statements)

References 29 publications

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“…Pre-exposure to cadmium induced a signifi cant decrease in gill GPx activity at 48 h ( P <0.01) compared with the other groups, suggesting that gill GPx activity was highly susceptible to cadmium exposure. Our observations are consistent with a previous study which concluded that inhibition of GPx was more pronounced in the gill than in the hepatopancreas (Cossu et al, 1997). We hypothesize that this difference refl ects the gills' role at the interface between the internal and external environments.…”

Section: Enzyme Activitiessupporting

confidence: 83%

Effect of cadmium on the defense response of Pacific oyster Crassostrea gigas to Listonella anguillarum challenge

Cong

et al. 2013

Chin. J. Ocean. Limnol.

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Heavy metal pollution can affect the immune capability of organisms. We evaluated the effect of cadmium (Cd) on the defense responses of the Pacifi c oyster Crassostrea gigas to Listonella anguillarum challenge. The activities of several important defensive enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPx), acid phosphatase (ACP), Na + , K + -ATPase in gills and hepatopancreas, and phenoloxidase-like (POL) enzyme in hemolymph were assayed. In addition, the expression levels of several genes, including heat shock protein 90 (HSP90), metallothionein (MT), and bactericidal/permeability increasing (BPI) protein were quantifi ed by fl uorescent quantitative PCR. The enzyme activities of SOD, ACP, POL, and GPx in hepatopancreas, and the expression of HSP90 were down-regulated, whereas GPx activity in the gill, Na + , K + -ATPase activities in both tissues, and MT expression was increased in Cdexposed oysters post L . anguillarum challenge. However, BPI expression was not signifi cantly altered by co-stress of L . anguillarum infection and cadmium exposure. Our results suggest that cadmium exposure alters the oysters' immune responses and energy metabolism following vibrio infection.

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Section: Enzyme Activitiessupporting

confidence: 83%

Effect of cadmium on the defense response of Pacific oyster Crassostrea gigas to Listonella anguillarum challenge

Cong

et al. 2013

Chin. J. Ocean. Limnol.

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“…CAT induction has been regarded as an adaptive behavior to an unsafe environment and an important early indicator of oxidative stress (Cossu et al, 1997). Increased levels of GST, CAT, lipidderived radicals and MT in ribbed mussels in summer may indicate the coordinated action of these responses to counteract different developmental, seasonal and environmental impacts during life cycle as it has been previously reported by Borković et al (2005).…”

Section: Discussionmentioning

confidence: 72%

Assessment of antioxidant responses and trace metal accumulation by digestive gland of ribbed mussel Aulacomya atra atra from Northern Patagonia

Giarratano

Gil

Malanga

2013

Ecotoxicology and Environmental Safety

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This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. Seasonal variations of trace metals did not appear to influence those of biochemical parameters, which generally showed an opposite trend with higher enzymatic activities in summer when trace metal concentrations were lower. Organisms from Punta Cuevas (control site) showed higher induction of reactive oxygen species production than those from both considered impacted sites, suggesting the possibility of some biochemical adaptation in organisms or a higher modulation of environmental and physiological factors on antioxidant responses than levels of trace metals. This study, which is the first in the area in this matter, showed that seasonal variations of potential biomarkers should be incorporated into interpretation of long-term biomonitoring studies in this marine coastal ecosystem.

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“…Contrary to these findings, some studies demonstrated increased activities of these enzymes in polluted environments [41]. In general, antioxidant enzymes can be induced by enhanced production of ROS as a protection mechanism, or inhibited in case of deficiency of the antioxidant system [42].…”

Section: Resultsmentioning

confidence: 85%

Antioxidant enzymes in the liver of Chelidonichthys obscurus from the Montenegrin coastline

et al. 2013

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The activities of antioxidant defence enzymes — total, manganese and copper zinc containing superoxide dismutase (Tot SOD, Mn SOD, CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST) — in the liver of longfin gurnard (Chelidonichthys obscurus) from the Montenegrin coastline (Adriatic sea) were investigated. The specimens were collected in winter (February) and late spring (May) at two localities: Platamuni (PL, potentially unpolluted) and the Estuary of the River Bojana (EB, potentially polluted). The obtained results show that the activities of Mn SOD, CAT, GSH-Px and GST in winter were significantly lower at EB than at PL. In spring, the activities of CAT and GST were decreased, while GR activity was increased at EB in comparison to PL. The activities of Mn SOD and GST at PL were decreased and GSH-Px, GR and GST activities at EB were increased in spring compared to winter. Our work represents the first study of liver antioxidant enzymes of longfin gurnard from the Montenegrin coastline and reveals that locality, as a variable, has a greater influence on antioxidant enzymes and biotransformation phase II enzyme GST activities compared to season.

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Glutathione Reductase, Selenium-Dependent Glutathione Peroxidase, Glutathione Levels, and Lipid Peroxidation in Freshwater Bivalves,Unio tumidus,as Biomarkers of Aquatic Contamination in Field Studies

Cited by 227 publications

References 29 publications

Effect of cadmium on the defense response of Pacific oyster Crassostrea gigas to Listonella anguillarum challenge

Effect of cadmium on the defense response of Pacific oyster Crassostrea gigas to Listonella anguillarum challenge

Assessment of antioxidant responses and trace metal accumulation by digestive gland of ribbed mussel Aulacomya atra atra from Northern Patagonia

Antioxidant enzymes in the liver of Chelidonichthys obscurus from the Montenegrin coastline

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