Glutathione peroxidase in human leukocytes

Origins of the discipline ‘neonatal haematology’, 1925–75

“…Many landmark reports of haematological findings of neonates that were published between 1925 and 1975 were not detailed in this review because they were outside the restricted topics selected. These significant other advances included differentiating adult from fetal haemoglobin in bloody stools by Apt and Downey (1955), diagnosing fetal to maternal haemorrhage (Kleihauer et al , 1957), Pearson's measurement of the life span of fetal erythrocytes (Pearson & Vertrees, 1961; Pearson, 1967), Zipursky's description of the morphology of erythrocytes of neonates (Zipursky, 1965), Miller's description of the poor chemotaxis of neutrophils of neonates (Miller, 1971), Boxer's description of congenital neutropenia of immune origin (Boxer & Stossel, 1974), Hathaway's work on the unique coagulation system and bleeding disorders of neonates (Hathaway, 1970, 1975), descriptions of neonatal immune‐mediated thrombocytopenia by Irving Schulman in 1960 and by Nathan Schulman in late 1950s and 1960s (Schulman, 1958; Schulman et al , 1964), Bracci's studies of glutathione peroxidase and hydrogen peroxide (Bracci et al , 1970a, b), and the work of Dr David Nathan's group on in utero diagnosis of haemoglobinopathies (Fig 10) (Chang et al , 1974). Indeed, Dr Nathan figures very prominently in the history of neonatal haematology (Nathan, 1958; Nathan et al , 1975) because he was responsible for training so many of the paediatric haematologists who made basic and clinical discoveries central to this field.…”