Glutathione-dependent degradation of parathion and its significance for resistance in the housefly

Oppenoorth, F. J.; Rupeš, V.; El-Bashir, S.; Houx, N.W.H.; Voerman, S.

doi:10.1016/0048-3575(72)90029-6

Cited by 64 publications

(13 citation statements)

References 17 publications

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“…Similarly, in the present study, GST activity was noticeably increased in the hemolymph, intestine, and fat bodies of H. armigera after treatment with entomopathogenic fungi. In M. domestica, organophosphates were detoxified by GST and insecticide resistance related to dichloronitrobenzene-GST and dichlorodiphenyltrichloroethane (DDT)-dehydrochlorine, identified as GST isoenzymes that are able to detoxify DDT (Oppenoorth et al 1972;Clark et al 1973Clark et al , 1976Motoyama & Dauterman 1975). The findings of the present study are in accordance with the results of Wang et al (1991), who reported increased GST activity in Musca domestica.…”

Section: Discussionsupporting

confidence: 91%

Activity of glutathione S‐transferase and esterase enzymes in Helicoverpa armigera (Hübner) after exposure to entomopathogenic fungi

Bilal

Freed

Muhammad

et al. 2018

Entomological Research

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Helicoverpa armigera, a polyphagous insect of crops and vegetables, is acquiring resistance against many commercial insecticides. The present study shows variations in the activity of two detoxification enzymes, namely esterase and glutathione S‐transferase (GST), in H. armigera after exposure to different isolates of entomopathogenic fungi. After treatment of larvae with the different isolates (Day 0), samples were collected on three days (Days 3, 5 and 7) for enzyme analysis. High GST activity was found in samples of hemolymph, intestine and fat bodies of H. armigera following treatment with Beauveria bassiana (isolate Bb‐08), Metarhizium anisopliae (isolates Ma‐11.1 and Ma‐4.1), and Isaria fumosorosea (isolates If‐02 and If‐2.3). High esterase activity was recorded in samples of the intestine and fat bodies on various days after treatment, whereas increased esterase activity in hemolymph was noted only in samples from Day 5 after treatment with M. anisopliae (Ma‐4.1). The detection of high GST and esterase activity demonstrates the possibility of the development of resistance against these microbial control agents in H. armigera.

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Section: Discussionsupporting

confidence: 91%

Activity of glutathione S‐transferase and esterase enzymes in Helicoverpa armigera (Hübner) after exposure to entomopathogenic fungi

Bilal

Freed

Muhammad

et al. 2018

Entomological Research

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“…Several studies have indicated that GSTs play an important role in the acquisition of resistance to insecticides. Some resistant insects have been found to metabolize insecticides more efficiently via a GSH-dependent route (Oppenoorth et al, 1972). High levels of GST activity have been detected in some resistant insect strains (Ottea and Plapp, 1984), and the resistance development has been correlated with enhanced GST activity and GST dependent insecticide metabolism (Fournier et al, 1987).…”

Section: Glutathione S-transferase (Gst)mentioning

confidence: 99%

Major putative pesticide receptors, detoxification enzymes, and transcriptional profile of the midgut of the tobacco budworm, Heliothis virescens (Lepidoptera: Noctuidae)

Zhu¹,

Guo²,

Chen

et al. 2011

Journal of Invertebrate Pathology

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“…The reaction results in the conjugation of glutathione to the material in question, which may then be exported out of the cell or further metabolized. In the house¯y, Musca domestica, strains that have, in recent years, become resistant to the insecticides lindane and the organophosphate triester dimethyl parathion have enhanced levels of GSTs compared to susceptible ancestors (Oppenoorth et al 1972;Clark et al 1982;Dauterman 1986). The GSTs protect the host against toxic chemicals because they have acquired the ability to recognize and use as substrates an unusually wide variety of potential xenobiotic chemical structures.…”

Section: Introductionmentioning

confidence: 98%

A complex glutathione transferase gene family in the housefly Musca domestica

Zhou

Syvanen

1997

Mol Gen Genet

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In most metazoans, the glutathione S-transferases (GST) are encoded by gene families, and are used to detoxify xenobiotics. We describe the structure of genomic loci coding for the GSTs in the housefly that have been implicated, by both genetic and biochemical means, in mediating insecticide resistance. In earlier work, we showed that one of the theta-class enzymes, MdGST-3, is overproduced in resistant flies and degrades certain insecticides. We used a fragment from a cDNA clone of MdGST-3 as a probe to screen a housefly genomic DNA bank in phage lambda. This probe detected multiple gst loci. Genes for GSTs were found in five different, nonoverlapping lambda clones, three of which carry multiple, closely linked gsts. Multiple genes for both MdGST-3 and MdGST-4 were found; some of which have introns in their 5' untranslated regions. In adults, the only MdGST-3 enzymes that are expressed are encoded by the intron-free genes. A new theta-class GST (called MdGST-5) was also discovered. Fusion genes comprising 5' MdGST-3 sequences and either MdGST-4 or MdGST-5 sequences in their 3' halves were encountered at three separate loci. The genes described here are found in both the ancestral sensitive strain and the insecticide-resistant strains.

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Glutathione-dependent degradation of parathion and its significance for resistance in the housefly

Cited by 64 publications

References 17 publications

Activity of glutathione S‐transferase and esterase enzymes in Helicoverpa armigera (Hübner) after exposure to entomopathogenic fungi

Activity of glutathione S‐transferase and esterase enzymes in Helicoverpa armigera (Hübner) after exposure to entomopathogenic fungi

Major putative pesticide receptors, detoxification enzymes, and transcriptional profile of the midgut of the tobacco budworm, Heliothis virescens (Lepidoptera: Noctuidae)

A complex glutathione transferase gene family in the housefly Musca domestica

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