Glutathione-capped, renal-clearable CuS nanodots for photoacoustic imaging and photothermal therapy

Liang, Guohai; Jin, Xudong; Qin, Huan; Xing, Da

doi:10.1039/c7tb01517h

Cited by 39 publications

(38 citation statements)

References 52 publications

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“…Contrastingly, the temperature of pure water elevated by <5 °C under the same experimental condition, indicating that laser irradiation alone at this power density could not induce sufficient photothermal effect, and the temperature elevation of the Fe‐ZDS solutions were mainly attributed to the NIR absorption and light‐to‐heat conversion of the complex. The photothermal conversion efficiency ( η ) of Fe‐ZDS, which was calculated according to the previously reported method, [ 20 ] was as high as 30.99% (Figure S6, Supporting Information). Next, the temperature change of the sample with the concentration of 70 µg mL −1 was traced under the irradiation of different power densities.…”

Section: Resultsmentioning

confidence: 99%

“…[11] As PTAs are inherently nontoxic, PTT generally has no significant systemic toxic side effects, thereby showing advantages of high specificity and easy regulation compared to chemotherapy and radiotherapy. For improved therapeutic efficacy, PTAs such as noble metal nanostructures, [12][13][14] nanocarbons, [15][16][17][18] and transition metal sulfide/oxides nanomaterials, [19][20][21] have been investigated for cancer PTT. These PTAs showed high near infrared (NIR) light absorbance and good photothermal efficiency; however, they are not biodegradable, leading to concerns regarding their long-term fate and safety in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Precise Tumor Photothermal Therapy Guided and Monitored by Magnetic Resonance/Photoacoustic Imaging using A Safe and pH‐Responsive Fe(III) Complex

Liang

Han

Xing

2020

Adv Healthcare Materials

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Photothermal agents with strong near infrared (NIR) optical absorbance and excellent biocompatibility and traceability are highly desired for precise photothermal therapy. This study reports the development of a dual-functional Fe 3+ complex (Fe-ZDS) for imaging-guided, precise photothermal therapy of tumors. The complex has stable structure and obvious zwitterionic features, resulting in excellent biocompatibility and efficient renal clearance. The iron-dopa core structure renders the complex capable of generating magnetic resonance imaging (MRI) contrast, while synergistically exhibiting optical absorption in the red and NIR regions. Interestingly, the optical absorption of the complex is pH-sensitive, with significantly higher absorption intensity in a weakly acidic environment than in a neutral environment. Thus the complex can respond to acidic tumor stimuli and confine the energy of the laser to the tumor tissue. The MRI contrast and photoacoustic signal of the complex is taken advantage of to monitor the probe injection process and optimize the injection position and dosage for maximally covering the tumor tissue and assessing the activation of the complex in tumor tissues. The evolution of temperature inside the tissue during the laser irradiation is also monitored. Using Fe-ZDS as the theranostic probe, satisfactory treatment outcomes are achieved for photothermal therapy of tumors.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Precise Tumor Photothermal Therapy Guided and Monitored by Magnetic Resonance/Photoacoustic Imaging using A Safe and pH‐Responsive Fe(III) Complex

Liang

Han

Xing

2020

Adv Healthcare Materials

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“…According to the reported method (Figure S6 and the calculation of the photothermal conversion efficiency section in the Supplementary materials), the PTT conversion efficiency was calculated to be 44.69%, which was higher than many CuS nanomaterials, such as PAA-CuS NCs (19.5%), CuS@CP (34%), GSH-CuS NDs (21.9%), and Cu 9 S 5 (25.7%). [46][47][48][49] Furthermore, no significant differences were observed in the temperature changes after four cycles of irradiation, demonstrating the excellent photostability of the PCCNs (Figure 3D). Therefore, the excellent PTT property and outstanding photostability of PCCNs allow these PCCNs to achieve efficient PTT effects in cancer treatment.…”

Section: The Photothermal Properties Of Pccnsmentioning

confidence: 94%

Tumor Microenvironment-Modulated Nanozymes for NIR-II-Triggered Hyperthermia-Enhanced Photo-Nanocatalytic Therapy via Disrupting ROS Homeostasis

Zhu¹,

Dai²,

Gao³

et al. 2021

IJN

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Purpose: Reactive oxygen species (ROS) are a group of signaling biomolecules that play important roles in the cell cycle. When intracellular ROS homeostasis is disrupted, it can induce cellular necrosis and apoptosis. It is desirable to effectively cascade-amplifying ROS generation and weaken antioxidant defense for disrupting ROS homeostasis in tumor microenvironment (TME), which has been recognized as a novel and ideal antitumor strategy. Multifunctional nanozymes are highly promising agents for ROS-mediated therapy. Methods: This study constructed a novel theranostic nanoagent based on PEG@Cu 2-x S@Ce6 nanozymes (PCCNs) through a facile one-step hydrothermal method. We systematically investigated the photodynamic therapy (PDT)/photothermal therapy (PTT) properties, catalytic therapy (CTT) and glutathione (GSH) depletion activities of PCCNs, antitumor efficacy induced by PCCNs in vitro and in vivo. Results: PCCNs generate singlet oxygen ( 1 O 2 ) with laser (660 nm) irradiation and use catalytic reactions to produce hydroxyl radical (•OH). Moreover, PCCNs show the high photothermal performance under NIR II 1064-nm laser irradiation, which can enhance CTT/ PDT efficiencies to increase ROS generation. The properties of O 2 evolution and GSH consumption of PCCNs achieve hypoxia-relieved PDT and destroy cellular antioxidant defense system respectively. The excellent antitumor efficacy in 4T1 tumor-bearing mice of PCCNs is achieved through disrupting ROS homeostasis-involved therapy under the guidance of photothermal/photoacoustic imaging. Conclusion:Our study provides a proof of concept of "all-in-one" nanozymes to eliminate tumors via disrupting ROS homeostasis.

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“…It is particularly important to develop an imaging method that does not require ionizing radiation. PA imaging only needs to be done by contrast agents such as small molecular dyes, organic and inorganic nanoparticles, reducing the potential harm of radiation to the matrix, and has been used in the diagnosis and research of cancer, microcirculation and cardiovascular diseases [64‐67] …”

Section: Biological Applications Related To Rtcsmentioning

confidence: 99%

Reduced Thiol Compounds – Induced Biosensing, Bioimaging Analysis and Targeted Delivery

et al. 2020

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Reduced thiol compounds (RTCs), such as glutathione (GSH), cysteine (Cys), and homocysteine (Hcy), are important components of many amino acids and proteins. They are also basic building blocks that make up organisms and play an important role in physiology and pathology. Therefore, based on the fundamental characteristics of RTCs in vivo, researchers have reported their use in biosensing and imaging analysis and as carriers in life sciences and health sciences. In this review, we will introduce the principles of RTCs and highlight their applications in biosensing and imaging analysis and as carriers reported from 2015 to 2020. Yingshu Guo (top left) obtained her Ph.D. degree from Qingdao University of Science and Technology in 2012. She is currently a professor at Linyi University, China, with research interests in bioanalytical chemistry and chemical biology. Xiaofei Zheng (top middle) obtained his B.S. degree from Linyi University in 2019. Then he pursued his M.S. degree under the supervision of Prof. Yingshu Guo at Linyi University. His current research is focused on bioanalytical chemistry. Xiuping Cao (top right) obtained her B.S. degree from Shandong University of Traditional Chinese Medicine in 2019. Then she pursued her M.S. degree under the supervision of Prof. Yingshu Guo at Linyi University. Her current research is focused on bioanalytical chemistry and chemical biology. Wenxin Li (bottom left) obtained her B.S. degree from Qilu Institute of Technology in 2020. Then she pursued her M.S. degree under the supervision of Prof. Yingshu Guo at Linyi University. Her current research is focused on bioanalytical chemistry and chemical biology. Di Wu (bottom middle) obtained her B.S. degree from Linyi University in 2020. Then she pursued her M.S. degree under the supervision of Prof. Yingshu Guo at Linyi University. Her current research is focused on bioanalytical chemistry. Shusheng Zhang (bottom right) obtained his Ph.D. degree from Nanjing University in 1999. He is a leading researcher at Linyi University with research interests in bioanalytical chemistry.

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Glutathione-capped, renal-clearable CuS nanodots for photoacoustic imaging and photothermal therapy

Abstract: Glutathione-capped copper sulfide nanodots with efficient renal clearance show promise for in vivo photoacoustic imaging and photothermal therapy.

Cited by 39 publications

References 52 publications

Precise Tumor Photothermal Therapy Guided and Monitored by Magnetic Resonance/Photoacoustic Imaging using A Safe and pH‐Responsive Fe(III) Complex

Precise Tumor Photothermal Therapy Guided and Monitored by Magnetic Resonance/Photoacoustic Imaging using A Safe and pH‐Responsive Fe(III) Complex

Tumor Microenvironment-Modulated Nanozymes for NIR-II-Triggered Hyperthermia-Enhanced Photo-Nanocatalytic Therapy via Disrupting ROS Homeostasis

Reduced Thiol Compounds – Induced Biosensing, Bioimaging Analysis and Targeted Delivery

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