No abstract

No abstract

No abstract

No abstract

In this paper, we investigate the combination of two key enabling technologies for the fifth generation (5G) wireless mobile communication, namely millimeter-wave (mmWave) communications and non-orthogonal multiple access (NOMA). In particular, we consider a typical 2-user uplink mmWave-NOMA system, where the base station (BS) equips an analog beamforming structure with a single RF chain and serves 2 NOMA users. An optimization problem is formulated to maximize the achievable sum rate of the 2 users while ensuring a minimal rate constraint for each user. The problem turns to be a joint power control and beamforming problem, i.e., we need to find the beamforming vectors to steer to the two users simultaneously subject to an analog beamforming structure, and meanwhile control appropriate power on them. As direct search for the optimal solution of the non-convex problem is too complicated, we propose to decompose the original problem into two sub-problems that are relatively easy to solve: one is a power control and beam gain allocation problem, and the other is an analog beamforming problem under a constant-modulus constraint. The rational of the proposed solution is verified by extensive simulations, and the performance evaluation results show that the proposed sub-optimal solution achieve a closeto-bound uplink sum-rate performance.

Polycations often suffer from the irreconcilable inconsistency between transfection efficiency and toxicity. Polymers with high molecular weight (MW) and cationic charge feature potent gene delivery capabilities, while in the meantime suffer from strong chemotoxicity, restricted intracellular DNA release, and low stability in vivo. To address these critical challenges, we herein developed pH-responsive, reversibly cross-linked, polyetheleneimine (PEI)-based polyplexes coated with hyaluronic acid (HA) for the effective and targeted gene delivery to cancer cells. Low-MW PEI was cross-linked with the ketal-containing linker, and the obtained high-MW analogue afforded potent gene delivery capabilities during transfection, while rapidly degraded into low-MW segments upon acid treatment in the endosomes, which promoted intracellular DNA release and reduced material toxicity. HA coating of the polyplexes shielded the surface positive charges to enhance their stability under physiological condition and simultaneously reduced the toxicity. Additionally, HA coating allowed active targeting to cancer cells to potentiate the transfection efficiencies in cancer cells in vitro and in vivo. This study therefore provides an effective approach to overcome the efficiency-toxicity inconsistence of nonviral vectors, which contributes insights into the design strategy of effective and safe vectors for cancer gene therapy.

No abstract

No abstract