volume 39, issue 3, P355-363 2006
DOI: 10.1590/s0100-879x2006000300006
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Abstract: AbstractGlutathione is the major intracellular antioxidant thiol protecting mammalian cells against oxidative stress induced by oxygen-and nitrogen-derived reactive species. In trypanosomes and leishmanias, trypanothione plays a central role in parasite protection against mammalian host defence systems by recycling trypanothione disulphide by the enzyme trypanothione reductase. Although Kinetoplastida parasites lack glutathione reductase, they maintain significant levels of glutathione. The aim of this study …

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