Glutathione and plant response to the biotic environment

Frendo, Pierre; Baldacci‐Cresp, Fabien; Benyamina, Sofiane Sm; Puppo, Alain

doi:10.1016/j.freeradbiomed.2013.07.035

Cited by 31 publications

(21 citation statements)

References 97 publications

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“…Glutathione is a master redox buffer in prokaryotes and eukaryotes, and plays a major role in plant redox homeostasis (Noctor et al ., ). Interestingly, glutathione is essential for the regulation of plant responses to environmental stresses, including immune responses (Frendo et al ., ; Ghanta and Chattopadhyay, ). Considering this, we speculated that the GGCT activity could contribute to RipAY immune suppression activities.…”

Section: Resultsmentioning

confidence: 99%

“…TRXs and glutathione have multiple targets in plant cells and regulate multiple processes in addition to biotic stress, such as abiotic stress and plant development (Frendo et al ., ; Gelhaye et al ., ; Ghanta and Chattopadhyay, ; Kneeshaw et al ., ; Noctor et al ., ; Tada et al ., ). Therefore, by targeting TRXs and glutathione, R. solanacearum could globally perturb plant signalling to benefit pathogen proliferation (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Further biochemical analysis showed that RipAY degrades glutathione in plant cells. Glutathione is a master redox buffer (Noctor et al ., ), which contributes to the activation of diverse immune responses (Frendo et al ., ; Ghanta and Chattopadhyay, ). RipAY immune suppression activities are abolished in a mutant affected on the catalytic core of GGCT activity, which cannot degrade glutathione.…”

Section: Discussionmentioning

confidence: 99%

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The Ralstonia solanacearum type III effector RipAY targets plant redox regulators to suppress immune responses

Sang

Wang

Hóng

et al. 2016

Molecular Plant Pathology

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The subversion of plant cellular functions is essential for bacterial pathogens to proliferate in host plants and cause disease. Most bacterial plant pathogens employ a type III secretion system to inject type III effector (T3E) proteins inside plant cells, where they contribute to the pathogen-induced alteration of plant physiology. In this work, we found that the Ralstonia solanacearum T3E RipAY suppresses plant immune responses triggered by bacterial elicitors and by the phytohormone salicylic acid. Further biochemical analysis indicated that RipAY associates in planta with thioredoxins from Nicotiana benthamiana and Arabidopsis. Interestingly, RipAY displays γ-glutamyl cyclotransferase (GGCT) activity to degrade glutathione in plant cells, which is required for the reported suppression of immune responses. Given the importance of thioredoxins and glutathione as major redox regulators in eukaryotic cells, RipAY activity may constitute a novel and powerful virulence strategy employed by R. solanacearum to suppress immune responses and potentially alter general redox signalling in host cells.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Ralstonia solanacearum type III effector RipAY targets plant redox regulators to suppress immune responses

Sang

Wang

Hóng

et al. 2016

Molecular Plant Pathology

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“…Предполагается, что глутатион и гомоглутатион играют различные роли в процессах развития растений и отве-та на стрессовое воздействие. Таким образом, несмотря на то, что многие функции глутатиона и гомоглутатиона перекрываются, у бобовых растений их синтез может изменяться по-разному в ответ на действие стрессора, однако причины таких варьирований еще остаются неиз-вестными (Frendo et al, 2013).…”

Section: обсуждение результатовunclassified

Gene expression analysis of genes coding key enzymes of cadmium detoxification in garden pea symbiotic nodules

Kulaeva

Tsyganov

2014

Ecological genetics

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Background. Cadmium is one of the most wide-ranging and dangerous pollutants for all living organisms, including plants. Currently, the mechanisms of cadmium accumulation in plant tissues and plant tolerance to its toxic effect are intensively studied. Metal-binding ligands, such as glutathione and phytochelatins, are one of the most important components in cadmium homeostasis in plants. Materials and methods. The pea line SGE and mutant SGECdt differed by cadmium tolerance were used. Gene expression for γ-glutamylcysteine synthetase (GSH1), glutathione synthetase (GSHS), homoglutathione synthetase (hGSHS) and phytochelatin synthase (PsPCS) was measured in pea nodules using realtime PCR. Results. GSH1 expression was slightly influenced by cadmium cloride. GSHS expression was upregulated in SGE and slightly downregulated in SGECdt. Cadmium cloride caused increased expression of hGSHS and PsPCS in both pea line SGE and the mutant SGECdt. Conclusion. Increased tolerance to cadmium of symbiotic nodules in the mutant SGECdt is not linked with expression pattern of analyzed genes.

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“…This mutant has been reported to contain only about 22% of wild-type amounts of GSH [16]. Recent reviews have suggested a strong involvement of GSH in plant-microbe interactions and that GSH deficiency in pad2-1 affects defense-related signaling events conferring susceptibility to pathogens [17,18]. Recently, the pad2-1 mutant has also been reported to exhibit vulnerability to combined osmotic and cold stress.…”

mentioning

confidence: 99%

Changes in the proteome of pad2-1, a glutathione depleted Arabidopsis mutant, during Pseudomonas syringae infection

Datta

Chattopadhyay

2015

Journal of Proteomics

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Glutathione and plant response to the biotic environment

Cited by 31 publications

References 97 publications

The Ralstonia solanacearum type III effector RipAY targets plant redox regulators to suppress immune responses

The Ralstonia solanacearum type III effector RipAY targets plant redox regulators to suppress immune responses

Gene expression analysis of genes coding key enzymes of cadmium detoxification in garden pea symbiotic nodules

Changes in the proteome of pad2-1, a glutathione depleted Arabidopsis mutant, during Pseudomonas syringae infection

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