Glutathione ameliorates liver markers, oxidative stress and inflammatory indices in rats with renal ischemia reperfusion injury

Ahmadvand, Hassan; Babaeenezhad, Esmaeel; Nasri, Maryam; Jafaripour, Leila; Khorramabadi, Reza Mohammadrezaei

doi:10.15171/jrip.2019.18

Cited by 20 publications

(14 citation statements)

References 19 publications

(29 reference statements)

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“…The serum activities of ALP and transaminases including aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were assayed on an auto-analyzer (Olympus AU-600, Tokyo, Japan) applying commercial kits (Pars Azmoon Company, Tehran, Iran) similar to our previous study [38].…”

Section: Evaluation Of Serum Activities Of Transaminases and Alpmentioning

confidence: 99%

Cinnamic acid ameliorate gentamicin-induced liver dysfunctions and nephrotoxicity in rats through induction of antioxidant activities

Babaeenezhad

Nouryazdan

Nasri

et al. 2021

Heliyon

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This study was the first to evaluate the possible protective effects of cinnamic acid (CA) against Gentamicin (GM) induced liver and kidney dysfunctions in rats. Adult male Wistar rats were randomly assigned to 4 equal groups (n ¼ 8): Control group (saline, 0.5 ml/day), CA group (CA, 50 mg/kg/day), GM group (GM, 100 mg/kg/day), and GM þ CA group (100 & 50 mg/kg/day). Following 12 days of treatments, blood and 24 h urine samples were collected and kidneys were taken out for biochemical, histopathological, and molecular studies. Following CA treatment, renal function markers and transaminases activities including serum urea (59.92%) and creatinine (50.41%), protein excretion rate (43.67%), and serum activities of aspartate aminotransferase (AST) (54.34%) and alanine aminotransferase (ALT) (47.26%) significantly reduced in the treated group as compared with the GM group (P < 0.05). Also, CA could significantly ameliorate the levels of triglyceride (29.70%), cholesterol (13.02%), very low-density lipoprotein (29.69%) and high-density lipoprotein-cholesterol (7.28%). CA could also attenuate oxidative stress through a decrease of serum malondialdehyde (MDA) (50.86%) and nitric oxide (NO) (0.85%) and an increase of renal catalase (CAT) (196.14%) and glutathione peroxidase (GPX) activities (45.88%) as well as GPX mRNA expression (44.42-fold) as compared with the GM group (P < 0.05). Moreover, histopathological evaluations revealed attenuated tubular damages and reduced inflammatory cellular infiltration in CA treated animals. Overall, CA alleviates GM-induced nephrotoxicity and alterations in transaminases activities in rats through its antioxidant activities.

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Section: Evaluation Of Serum Activities Of Transaminases and Alpmentioning

confidence: 99%

Cinnamic acid ameliorate gentamicin-induced liver dysfunctions and nephrotoxicity in rats through induction of antioxidant activities

Babaeenezhad

Nouryazdan

Nasri

et al. 2021

Heliyon

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“…Serum PON 1 activity was measured by the utilization of paraoxon as a substrate similar to our previous study [33].…”

Section: Serum Paraoxonase 1 (Pon 1) Activitymentioning

confidence: 99%

Renoprotective Effects of Gallic Acid Against Gentamicin Nephrotoxicity Through Amelioration of Oxidative Stress in Rats

Ahmadvand

Nouryazdan

Nasri

et al. 2020

Braz. arch. biol. technol.

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Gallic acid (GA), as a strong antioxidant, was selected in this study to investigate its possible nephroprotective effects against gentamicin (GM)-induced nephrotoxicity. Twenty-four rats were separated into three groups (n=8): group 1 (control group) received saline (0.5 mL/day), group 2 (GM group) received GM (100 mg/kg/day), and group 3 (treated group) received GM (100 mg/kg/day) and GA (100mg/kg/day). All treatments were performed intraperitoneally for 12 days. After 12 days, the rats were euthanized, and kidneys were removed immediately. For serum preparation, blood samples were collected before killing. Kidney paraffin sections were prepared from one of the kidneys and stained by the periodic acid-Schiff process. GA significantly decreased GM-induced renal histopathological injuries, including tubular necrosis, tubular cast, and leucocyte infiltration compared with the GM group. Additionally, GA significantly improved proteinuria, serum levels of urea and creatinine, and serum activities of aspartate aminotransferase (AST) and alanine HIGHLIGHTS  Gallic acid ameliorates gentamicin-induced nephrotoxicity.  Gallic acid decreases levels of NO and MDA and enhances abilities of GSH, GPX, and CAT.  Gallic acid improves altered liver and renal function markers in nephrotoxic animals.  Gallic acid reduces renal histopathological injuries.  2 Ahmadvand, H.; et al.

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“…The results of the present study showed that there is an inverse association between the level of MDA and the level of GSH in the serum of people with parasite, and this is consistent with other studies.A number of studies have shown that there is an inverse relationship between GSH and MDA, In their study, Ahmadvand et al (31) indicated that the injection of GSH into peritoneal cavity in rats with Kidney ischemia leads to a lower serum MDA level compared to non-injected rats. Chen et al (32) reported a decrease in the value of MDA and a change in oxidative stress when GSH was supplied orally to obstructive jaundice rats.…”

Section: Discussionmentioning

confidence: 99%

Amoebic dysentery patients and two important signs (Malondialdehyde and Glutathione) of oxidative stress

Kadhim¹,

Jawad²,

Shaalan³

2019

ATMPH

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A total of 50 human blood samples with Amoebic dysentery were obtained from people between the ages of 7-66 years for a period of three months from November 2017 to January 2018 from three hospitals (Murjan Medical City hospital, AL-HillaTeachinghospital, and AL-Mahaweel hospital) in Babylon province, Iraq. While the other 30 samples of healthy people (7-63 years) were seen as a control group, were collected from donors from Babylon Governorate to assess the state of oxidative stress in people with acute Entamoebahistolytica infections.The state of oxidative stress was determined by valuing the levels of serum malondialdehyde (MDA) and serum glutathione (GSH) as an indicator of lipid peroxidation and antioxidant status respectively. Serum MDA and serum GSH levels for Group of sick people were 18.125± 4.56μmol/L and 194.434±23μmol/L respectively, which MDA level was significantly higher than that in the control group 13.285 ± 2.87μmol/L whereas the GSH level was lower than that in the control group 559.25±55μmol/L (P<0.001). Serum MDA levels were increased significantly with increasing age (P<0.001). The acute infection of the amoeba parasite under study was directly associated with a sharp increase in free radicals by increasing MDA levels and lower GSH levels in people with parasite compared to uninfected persons, confirming the important role of parasites in inducing oxidative stress.

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Glutathione ameliorates liver markers, oxidative stress and inflammatory indices in rats with renal ischemia reperfusion injury

Cited by 20 publications

References 19 publications

Cinnamic acid ameliorate gentamicin-induced liver dysfunctions and nephrotoxicity in rats through induction of antioxidant activities

Cinnamic acid ameliorate gentamicin-induced liver dysfunctions and nephrotoxicity in rats through induction of antioxidant activities

Renoprotective Effects of Gallic Acid Against Gentamicin Nephrotoxicity Through Amelioration of Oxidative Stress in Rats

Amoebic dysentery patients and two important signs (Malondialdehyde and Glutathione) of oxidative stress

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