Glutaraldehyde colitis following endoscopy: Clinical and pathological features and investigation of an outbreak

West, A. Brian; Kuan, Shih–Fan; Bennick, Michael; Lagarde, Suzanne

doi:10.1016/0016-5085(95)90227-9

Cited by 80 publications

(27 citation statements)

References 15 publications

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“…The child finally recovered without sequelae. It was reported that colitis was induced by retention of 2% GA disinfectant in endoscope channels 23,24) . The acute toxicity of GA has been investigated in many studies with various animal species 2,[25][26][27] .…”

Section: Acute Toxicitymentioning

confidence: 99%

Effects of Glutaraldehyde Exposure on Human Health

Takigawa

Endo

2006

Journal of Occupational Health

239

147

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Section: Acute Toxicitymentioning

confidence: 99%

Effects of Glutaraldehyde Exposure on Human Health

Takigawa

Endo

2006

Journal of Occupational Health

239

147

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“…Glutaraldehyde-induced colitis presents clinically with severe abdominal pain, bloody and mucoid diarrhea, rectal bleeding, and tenesmus 48 h after colonoscopy. There are also some cases that presented 5-12 h after the colonoscopy [1,7]. Endoscopic findings include nonspecific exudative fibrinohemorrhagic and purulent membranes consistent with erosion or ulceration of the mucosa, which mimics ischemic colitis, inflammatory bowel disease and pseudomembranous enterocolitis [1,7,8].…”

Section: Discussionmentioning

confidence: 99%

“…There are also some cases that presented 5-12 h after the colonoscopy [1,7]. Endoscopic findings include nonspecific exudative fibrinohemorrhagic and purulent membranes consistent with erosion or ulceration of the mucosa, which mimics ischemic colitis, inflammatory bowel disease and pseudomembranous enterocolitis [1,7,8]. Histopathologically, there is a marked congestion and extravasation of red blood cells in the superficial lamina propria, mucin depletion, attenuation or loss of the epithelium lining, the surface and the upper portion of the glands, a surface erosion with a fibrinohemorrhagic, purulent exudate, preservation of the regenerative base of the crypts, and a scant inflammatory cellular infiltrate.…”

Section: Discussionmentioning

confidence: 99%

Chemical Colitis Due to Glutaraldehyde: Case Series and Review of the Literature

et al. 2008

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Chemical colitis can occur as a result of accidental contamination of endoscopes or by intentional/accidental administration of enemas containing various chemicals.We present three cases of glutaraldehyde induced colitis and review the cases in the literature. Glutaraldehyde induced colitis presents clinically with severe abdominal pain, bloody and mucoid diarrhea, rectal bleeding, and tenesmus 48-72 h after colonoscopy. Endoscopic findings are nonspecific and mimic ischemic colitis, inflammatory bowel disease, and infectious colitis. The timing of symptoms and the knowledge that glutaraldehyde is a chemical irritant to colonic mucosa is important for the diagnosis. The treatment is mainly supportive but sometimes necessitates mesalamine, prednisolone, or metronidazole and the resolution is rapid. In endoscopy units, strict adherence to published disinfection protocols is very important and the cleaning, rinsing and drying protocols also deserve the same attention.

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“…Reports of human exposure to GA and QACs are limited to a few individual cases [3][4][5] and there are no reports of acute ingestion. The lack of reports is likely due to its lack of common use in domestic or agricultural settings.…”

Section: Discussionmentioning

confidence: 99%

Laryngeal edema and metabolic acidosis after Omnicide® ingestion

Perera¹,

Kularathne²,

Gawarammana³

2008

Clinical Toxicology

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Introduction. Glutaraldehyde and quaternary ammonium compounds are widely used as disinfectants and sterilizing agents. Glutaraldehyde is irritating to the eyes and upper respiratory tract, and has been associated with occupational asthma. Acute oral ingestion of a concentrated solution has not been previously reported in humans. Case Report. A 19-year-old woman presented after deliberate ingestion of a biocide containing glutaraldehyde and a quaternary ammonium compound. She developed respiratory distress and severe metabolic acidosis 10 hours after admission. Marked laryngeal edema was noted when she was being intubated. She eventually improved following supportive care and was discharged alive after 9 hospital days. Discussion. There are no reports of acute ingestions of both glutaraldehyde and quaternary ammonium compounds. As both these substances are known to cause metabolic acidosis, localized edema, erosion and sensitization of both the respiratory and alimentary tract. The clinical effect may be additive or synergistic. Conclusions. Omnicide ingestion should be closely monitored for metabolic acidosis and laryngeal edema which may progress to upper airway obstruction requiring urgent airway stabilization.

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Glutaraldehyde colitis following endoscopy: Clinical and pathological features and investigation of an outbreak

Cited by 80 publications

References 15 publications

Effects of Glutaraldehyde Exposure on Human Health

Effects of Glutaraldehyde Exposure on Human Health

Chemical Colitis Due to Glutaraldehyde: Case Series and Review of the Literature

Laryngeal edema and metabolic acidosis after Omnicide® ingestion

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