Glutamic oxalacetic transaminase in the evaluation of acute injury to the head

Cerebrospinal fluid enzymes in acute brain injury. 2. Relation of CSF enzyme activity to extent of brain injury.

“…Smith et al (1960) found that patients with either persisting or greatly raised values of GOT in the CSF also had the most extensive brain damage. In these patients it was predictable that neurological defects would persist.…”

“…Very little experimental work on the relation between the enzyme activity of the CSF and the extent of brain damage has been done (Smith et al, 1960;Wakim and Fleischer, 1956). Smith et al (1960) established this relation in a limited number of dog experiments.…”

“…Although prognostic value has been attributed by various authors to the level of CSF enzyme activity in patients with severe head injuries (Smith et al, 1960;del Villar et al, 1973), few clinical or experimental studies have correlated the changes in CSF enzyme activity with the extent of brain damage in the acute phase after brain trauma (Smith et al, 1960; Akashi, 1966;Florez et al, 1975). To investigate this relationship standardised cold injuries of different severity were made in three series of cats.…”

Cerebrospinal fluid enzymes in acute brain injury: 3 Effect of hypotension on increase of CSF enzyme activity after cold injury in cats

“…It was thought that the amount of enzymes released from injured brain tissue into the CSF would be related to the extent of brain damage, and so could be of prognostic value (Smith et al, 1960;del Villar et al, 1973). However, the prognostic value of CSF enzyme levels must depend also on the consistency with which enzymes released from damaged or necrotic brain cells are transported to the CSF.…”

Cerebrospinal fluid enzymes in acute brain injury. 1. Dynamics of changes in CSF enzyme activity after acute experimental brain injury.

“…Prognostic value has been attributed to the height of the CSF enzyme activity in patients with severe head injuries (Smith et al, 1960;del Villar et-al., 1973). More recently Nordby et al (1975) found higher concentrations of CPK and LDH in the CSF of patients with more severe brain injuries, but no close relationship between the severity of a moderate brain injury and the social rehabilitation or late effects could be shown.…”