Cerebrospinal fluid enzymes in acute brain injury. 1. Dynamics of changes in CSF enzyme activity after acute experimental brain injury.

Maas, Andrew I. R.

doi:10.1136/jnnp.40.7.655

Cited by 43 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have demonstrated high levels of especially CPK, HBDH, LDH, and GOT in the CSF of cats in which a cold lesion of the brain had been induced. Isoenzyme studies on CPK and LDH confirmed that these enzymes were of cerebral origin (Maas, 1977).…”

Section: Discussionmentioning

confidence: 85%

“…The experimental model as well as anaesthetic and surgical methods were as described by Maas (1977). Experimental brain injury was effected by induction of cold lesions to the brain.…”

Section: Methodsmentioning

confidence: 99%

“…Respiratory frequency and heart rate were also calculated. After the control period as described by Maas (1977) a cold lesion was induced in 31 of the 38 animals. The other seven animals, which served as a control series, were those used as controls in the earlier paper.…”

Section: Methodsmentioning

confidence: 99%

“…If tentorial herniation developed, the experiments were terminated prematurely as CSF could no longer be obtained from the cisternal catheter in quantities sufficient for analysis. The criteria for brain stem herniation have already been described (Maas, 1977).…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Cerebrospinal fluid enzymes in acute brain injury. 2. Relation of CSF enzyme activity to extent of brain injury.

Maas¹

1977

Journal of Neurology, Neurosurgery & Psychiatry

Self Cite

View full text Add to dashboard Cite

SUMMARY The value of CSF enzyme estimations as indices of the extent of brain damage was studied in the experimental situation. Standard cold lesions of different severity were induced in cats. The activities of the enzymes CPK, HBDH, LDH, GOT, and ChE were studied at half hour intervals in the cerebrospinal fluid (CSF). The ventricular and cisternal fluid pressure, and the arterial blood pressure were monitored continuously. Significantly higher enzyme levels were found in the animals with more severe injuries of the brain.

show abstract

Section: Discussionmentioning

confidence: 85%

“…The experimental model as well as anaesthetic and surgical methods were as described by Maas (1977). Experimental brain injury was effected by induction of cold lesions to the brain.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Cerebrospinal fluid enzymes in acute brain injury. 2. Relation of CSF enzyme activity to extent of brain injury.

Maas¹

1977

Journal of Neurology, Neurosurgery & Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recent studies have shown that the activity of creatine kinase (CK) in lumbar spinal fluid (CSF) gives a good indication of the degree of cerebral damage and prognosis in patients resuscitated after cardiac arrest." 2 Substantial increase in CSF-CK was associated with severely depressed brain function and death of all patients, while patients with negligible rise in CSF-CK recovered without gross intellectual or sensory-motor defects.…”

mentioning

confidence: 99%

The relationship between cerebrospinal fluid creatine kinase and morphologic changes in the brain after transient cardiac arrest.

Vaagenes¹,

Kjekshus²,

Torvik³

1980

Circulation

View full text Add to dashboard Cite

SUMMARY Recent studies have shown that the increase in creatine kinase (CK) in lumbar spinal fluid (CSF) can effectively predict the outcome of cerebral ischemia after cardiac arrest. In the present investigation maximum CSF-CK concentrations in 40 patients who died more than 3 days after successful cardiopulmonary resuscitation were related to the histologic brain damage. Different regions of the brain show different sensitivity to anoxia.3 It is therefore conceivable that ischemic damage to small but functionally important areas of the brain may give only a small rise in CSF-CK. Further, variations in the speed of release of CK into the CSF and its appearance in the lumbar region might influence the reliability of the method as an indicator of brain damage. The present study was undertaken to correlate maximum levels of CK in the lumbar CSF with the degree of ischemic damage in the whole brain and in different brain regions at autopsy.

show abstract

Creatine Kinase BB Isoenzyme in CSF in Neurologic Diseases

Pfeiffer¹,

Homburger²,

Yanagihara³

1983

Arch Neurol

View full text Add to dashboard Cite

Cerebrospinal fluid enzymes in acute brain injury. 1. Dynamics of changes in CSF enzyme activity after acute experimental brain injury.

Cited by 43 publications

References 25 publications

Cerebrospinal fluid enzymes in acute brain injury. 2. Relation of CSF enzyme activity to extent of brain injury.

Cerebrospinal fluid enzymes in acute brain injury. 2. Relation of CSF enzyme activity to extent of brain injury.

The relationship between cerebrospinal fluid creatine kinase and morphologic changes in the brain after transient cardiac arrest.

Creatine Kinase BB Isoenzyme in CSF in Neurologic Diseases

Contact Info

Product

Resources

About