Glutamic acid promotes hair growth in mice

Jara, Carlos Poblete; Berti, Beatriz de Andrade; Mendes, Nelson F.; Engel, Daiane F.; Zanesco, Ariane Maria; Souza, Gabriela de Nardi; Velloso, Lı́cio A.; Araujo, Eliana P.

doi:10.1101/2020.09.27.315523

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…For Fold change, we used non-diabetic “healthy” skin as reference (39, 40). As previously described (41), we used In silico analyses were performed using a DELL workstation with 16 GB RAM and four-cores Intel i7 processor. Sample expression matrices were downloaded from Gene Expression Omnibus Archive: GSE142471 and GSE165816.…”

Section: Methodsmentioning

confidence: 99%

A Diabetic Mice Model For Studying Skin Wound Healing

Jara

Nogueira

Morari

et al. 2022

Preprint

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Advances in wound treatment depend on the availability of animal models that reflect key aspects of human wound healing physiology. To this date, the accepted mouse models do not reflect defects in the healing process for chronic wounds that are associated with type two diabetic skin ulcers. The long term, systemic physiologic stress that occurs in middle aged or older type 2 diabetic patients is difficult to simulate in preclinical animal model. We have strived to incorporate the essential elements of this stress in a manageable mouse model: long term metabolic stress from obesity to include the effects of middle age and thereafter onset of diabetes. At six-weeks age, male C57BL/6 mice were separated into groups fed a Chow and High-Fat Diet for 0.5, 3, and 6 months. Treatment groups included long term, obesity stressed mice with induction of diabetes by streptozotocin at 5 months, and further physiologic evaluation at 8 months old. We show that this model results in a severe metabolic phenotype with insulin resistance and glucose intolerance associated with obesity and, more importantly, skin changes. The phenotype of this older age mouse model included a transcriptional signature of gene expression in skin that overlapped that observed with elderly patients who develop diabetic foot ulcers. This unique old age phenotype result contrasts with current non-obesity stressed mice models with induced diabetes at 4 months or younger which do not reflect the pathologic type 2 human phenotype.

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Section: Methodsmentioning

confidence: 99%

A Diabetic Mice Model For Studying Skin Wound Healing

Jara

Nogueira

Morari

et al. 2022

Preprint

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“…Moreover, these formulated blends effectively alleviated the stickiness and tingling sensations commonly experienced with polyhydric alcohols when applied to hair, while demonstrating notable moisturizing benefits for both hair and skin. Thus, this research underscored the potential of incorporating polyhydric alcohol and PGA into cosmetic formulations to address hair and skin care needs simultaneously [96][97][98][99].…”

Section: The Potential Of Poly-γ-glutamic Acid In Haircarementioning

confidence: 99%

Polyglutamate: Unleashing the Versatility of a Biopolymer for Cosmetic Industry Applications

Serra,

Gudina,

Botelho

et al. 2024

Cosmetics

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Polyglutamic acid (PGA), a biopolymer comprising repeating units of glutamic acid, has garnered significant attention owing to its versatile applications. In recent years, microbial production processes have emerged as promising methods for the large-scale synthesis of PGA, offering advantages such as sustainability, efficiency, and tailored molecular properties. Beyond its industrial applications, PGA exhibits unique properties that render it an attractive candidate for use in the cosmetic industry. The biocompatibility, water solubility, and film-forming characteristics of PGA make it an ideal ingredient for cosmetic formulations. This article explores the extensive potential cosmetic applications of PGA, highlighting its multifaceted role in skincare, haircare, and various beauty products. From moisturizing formulations to depigmentating agents and sunscreen products, PGA offers a wide array of benefits. Its ability to deeply hydrate the skin and hair makes it an ideal ingredient for moisturizers, conditioners, and hydrating masks. Moreover, PGA’s depigmentating properties contribute to the reduction in hyperpigmentation and uneven skin tone, enhancing the overall complexion. As the demand for sustainable and bio-derived cosmetic ingredients escalates, comprehending the microbial production and cosmetic benefits of PGA becomes crucial for driving innovation in the cosmetic sector.

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“…It is also known to be effective for large wounds, surgical wounds, and wounds resulting from chemotherapy and radiation treatments. Despite these advantages, glutamic acid is limited by its low solubility in water [7.5 g/L (20°C)], making it difficult to include it in cosmetics or ointments at high concentrations 13 . An ion pair of arginine and glutamic acid (RE:pair) serves as an effective system for overcoming the solubility limit of glutamic acid and increasing the skin permeability of both amino acids.…”

Section: Introductionmentioning

confidence: 99%

Effects of arginine glutamate (RE:pair) on wound healing and skin elasticity improvement after CO₂ laser irradiation

Kwon¹,

Won²,

Seo³

et al. 2022

J of Cosmetic Dermatology

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Background: Glutamic acid is known to be effective for keratinocyte proliferation, but its dermatological application is limited due to its poor solubility in water and various solvents.Aim: Here, the efficacy of the arginine glutamate ion pair (named as RE:pair) for recovering damaged skin and improving skin elasticity was investigated through the analysis of keratinocyte proliferation and collagen synthesis.Methods: Following the structural analysis of RE:pair using spectroscopic methods, a scratch assay, and Pro-Collagen I ELISA, skin tissue changes in wound-induced artificial skin, changes in wound area after laser wound induction, and the sensory evaluation of skin improvement were investigated.Results: As a result of scratch assay, wound recovery of 94.55% ± 9.57% was confirmed at 10 ppm RE:pair treatment. When evaluation of expression efficacy of procollagen type I, it was found that the expression rate was increased by 32.47% ± 5.62% compared with the control group. Further, the upregulation of the proliferation marker Ki-67 and filaggrin expression in the damage-induced artificial skin was verified.Clinically, the improvement was subjectively verified in terms of the reduction of the wound area, the restoration of the barrier, the improvement of skin elasticity, and through the sensory experience of skin improvement. Conclusion:RE:pair shows a greater therapeutic effect than the individual effects of its constituent amino acids and those of the simple mixtures of these compounds. RE:pair exerts its therapeutic action by promoting the proliferation of keratinocytes and enhancing collagen synthesis in fibroblasts. Accordingly, it can be used throughout the cosmetic industry as an effective amino acid wound healing and skin elasticity improving material.

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Glutamic acid promotes hair growth in mice

Cited by 3 publications

References 26 publications

A Diabetic Mice Model For Studying Skin Wound Healing

A Diabetic Mice Model For Studying Skin Wound Healing

Polyglutamate: Unleashing the Versatility of a Biopolymer for Cosmetic Industry Applications

Effects of arginine glutamate (RE:pair) on wound healing and skin elasticity improvement after CO₂ laser irradiation

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Glutamic acid promotes hair growth in mice

Cited by 3 publications

References 26 publications

A Diabetic Mice Model For Studying Skin Wound Healing

A Diabetic Mice Model For Studying Skin Wound Healing

Polyglutamate: Unleashing the Versatility of a Biopolymer for Cosmetic Industry Applications

Effects of arginine glutamate (RE:pair) on wound healing and skin elasticity improvement after CO2 laser irradiation

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Product

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Effects of arginine glutamate (RE:pair) on wound healing and skin elasticity improvement after CO₂ laser irradiation