Glued periosteal grafts in the knee

Niedermann, Bent; Boe, Svend; Lauritzen, J; Rubak, Jens M.

doi:10.3109/17453678508993034

Cited by 107 publications

(45 citation statements)

References 5 publications

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“…There are only a few studies of repair enhancement of isolated chondral defects in patients (Engkvist and Johansson 1980, Sully et al 1980, Niederman et al 1985, Muckle and Minns 1989, Hoikka et al 1990, Homminga et al 1990, Jensen and Bach 1992, Bulstra et al 1993, Brittberg et al 1994a, 1994b, Lorentzon et al 1996 and usually the number of patients is small. Tippett (1996) and Johnson (1996) have reported the clinical outcome with use of Pridie drilling or abrasion chondroplasty with or without osteotomy for knee chondral defects.…”

Section: I N Ical Studiesmentioning

confidence: 99%

Cartilage repair: A critical review

Messner

Gillquist

1996

Acta Orthopaedica Scandinavica

166

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Section: I N Ical Studiesmentioning

confidence: 99%

Cartilage repair: A critical review

Messner

Gillquist

1996

Acta Orthopaedica Scandinavica

166

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“…Various techniques have been developed to repair articular defects, for example, articular resurfacing, 1,2 transplantation of heterologous or autologous chondrocytes, [3][4][5][6][7][8][9][10] periosteum, [11][12][13][14] perichondrium, [15][16][17] osteochondral grafts, 18,19 meniscal allograft, 20 and prostheses using artificial materials. 21 These have been studied in animals and humans by many researchers.…”

Section: Introductionmentioning

confidence: 99%

Human chondrocyte proliferation and matrix synthesis cultured in Atelocollagen� gel

Uchio

Ochi

Matsusaki

et al. 2000

J. Biomed. Mater. Res.

114

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To evaluate the potential of Atelocollagen gel as a carrier for chondrocyte transplantation, histological and biochemical characteristics of the chondrocytes in gel culture were compared with those in conventional monolayer cultures. Articular chondrocytes from 20 patients were isolated by enzyme digestion, embedded in Atelocollagen gel, and cultured for up to 4 weeks. The effects on proliferation, morphological changes, and synthesis of proteoglycans were analyzed by cell counts, light and electron microscopy, and measurement of isomers of chondroitin sulfates. Chondrocytes embedded in the Atelocollagen gel gradually proliferated and produced chondroitin 6-sulfate, maintaining the chondrocyte phenotype for up to 4 weeks. In contrast, although monolayer chondrocytes increased in number, most could be characterized as being fibroblast-like cells with a reduced capability of producing chondroitin 6-sulfate. The results suggest that Atelocollagen gel permitted a gradual proliferation and matrix synthesis of chondrocytes and maintaining its phenotype. Atelocollagen gel represents an important carrier for the clinical application of cultured chondrocyte transplantation for repair of cartilage defects.

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“…These characteristics make autologous periosteal transplantation a viable method for treating cartilage defects. This procedure is used clinically to treat patients [1,18,23,24,30,45], and is also used experimentally in animals [26,28,32,33,46,49]. The main limitation of this procedure is the variability in cartilage produced by the transplanted periosteum.…”

Section: Introductionmentioning

confidence: 99%

Induction of CD‐RAP mRNA during periosteal chondrogenesis

Sanyal

Clemens

Fitzsimmons

et al. 2003

Journal Orthopaedic Research

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Induction of chondrogenesis and maintenance of the chondrocyte phenotype are critical events for antologous periosteal transplantation, which is a viable approach for cartilage repair. Cartilage-derived retinoic acid-sensitive protein (CD-RAP) is a recently discovered protein that is mainly produced in cartilage. During development, CD-RAP expression starts at the beginning of chondrogenesis and continues throughout cartilage maturation. In order to investigate the involvement of CD-RAP during periosteal chondrogenesis we have determined the nucleotide sequence of the rabbit CD-RAP mRNA and utilized this information to evaluate the temporal and spatial expression pattern of CD-RAP at the mRNA level during chondrogenesis. When the periosteal explants were cultured under chondrogenic conditions, the expression of CD-RAP was induced, as shown by a 40-fold increase in CD-RAP mRNA between days 7 and 10. The temporal expression pattern of CD-RAP closely mimicked that of collagen type IIB mRNA. Also, the CD-RAP mRNA was localized to the matrix forming chondrocytes in the cambium layer of the periosteum by in situ hybridization as indicated by colocalization with collagen type TI mRNA and positive safranin 0 staining. These data suggest a regulatory role of CD-RAP in periosteal chondrogenesis, which is potentially important for both cartilage repair and fracture healing via callus formation.

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Glued periosteal grafts in the knee

Cited by 107 publications

References 5 publications

Cartilage repair: A critical review

Cartilage repair: A critical review

Human chondrocyte proliferation and matrix synthesis cultured in Atelocollagen� gel

Induction of CD‐RAP mRNA during periosteal chondrogenesis

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