Cartilage repair: A critical review

Messner, Karola; Gillquist, Jan

doi:10.3109/17453679608996682

Cited by 169 publications

(85 citation statements)

References 31 publications

(58 reference statements)

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“…Healing often occurs by the formation of fibrocartilage, a tissue that is softer and less durable than hyaline cartilage. 15 Animal experiments, in which cartilage has been damaged in order to learn about treatment, show that various methods, including chondrocyte transplantation, are inconsistent at producing repair. In general, results in rabbits appear to be more favourable than results in other species, especially dogs.…”

Section: Laboratory Studiesmentioning

confidence: 99%

Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review

Jobanputra

Parry

Fry‐Smith

et al. 2001

Health Technol Assess

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents, York Publishing Services by:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS and public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please contact York Publishing Services at the address above. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to York Publishing Distribution and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.ncchta.org/htacd.htm). Or contact York Publishing Services (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTAEffectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review This report should be referenced as follows:Jobanputra P, Parry D, Fry-Smith A, Burls A. Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review. Health Technol Assess 2001;5(11).Health Technology Assessment is indexed in Index Medicus/MEDLINE and Excerpta Medica/ EMBASE. Copies of the Executive Summaries are available from the NCCHTA website (see opposite). NHS R&D HTA ProgrammeT he NHS R&D Health Technology Assessment (HTA) Programme was set up in 1993 to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and provide care in the NHS.The research reported in this monograph was commissioned by the HTA Programme on behalf of the National Institute for Clinical Excellence (NICE). Rapid reviews are completed in a limited time to inform the appraisal and guideline development processes managed by NICE. The review brings together evidence on key aspects of t...

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Section: Laboratory Studiesmentioning

confidence: 99%

Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review

Jobanputra

Parry

Fry‐Smith

et al. 2001

Health Technol Assess

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“…The implantation of autologous chondrocytes has been used for the treatment of full-thickness cartilage lesions. It is worth noting that this method is not effective for treatment of many types of lesions such as deep defects involving the subchondral bone [9,10] . Different scaffolds with osteochondral regenerative potential have been provided in order to overcome problems of joint treatment, and promising findings were achieved using these scaffolds [11,12] .…”

Section: Introductionmentioning

confidence: 99%

“…The repair of articular cartilage remained as a challenge for many years particularly because of cartilage's hypocellularity and insufficient nutrient supply. Furthermore, other factors responsible for delayed healing include the inability of bone marrow stem cells or resident chondroprogenitor cells for hyaline cartilage formation played role [2][3][4][5][6][7][8][9][10] . ACI has been demonstrated to be promising when implanting culture-expanded chondrocytes alone in clinical trials [7,8] .…”

Section: Introductionmentioning

confidence: 99%

Tavşanlarda Artikular Kartilaj Defekt Onarımında Devekuşu Plantar Ligament Kökenli Hücre İçermeyen Matriks Doku Kullanımı

Moridpour¹,

Fattahian²,

Mortazavi³

2017

Kafkas Univ Vet Fak Derg

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Citation of This ArticleMoridpour R, Fattahian HR, Mortazavi P: Using cell-free matrix derived from ostrich plantar ligament for repair of articular cartilage defect of rabbit. Kafkas Univ Vet Fak Derg, 23 (5): 707-713, 2017. DOI: 10.9775/kvfd.2017 Abstract Articular cartilage lesions are most common injury of the knee for which several repair methods have been described. We described in-vivo potential of collagen type I scaffold extracted fromknee of ostrich. Full thickness defects were created bilaterally in the weight bearing area of femoral condyles of the both femurs of 7 white New zealand adult male rabbits weighting 1800±100 g. The six left medial condyles as experimental group I were filled by using cell-free tissue and six right medial condyles of the same rabbit were treated by cell-tissue as experimental group II and the right medial condyle defect of one rabbit as control group was left without treatment. Histopathology data demonstrated significant difference between three groups with respect to the cartilage repair indicators as the morphology of the cells, color matrix and cartilage thickness (P<0.05). Furthermore, sub-chondral bone formation showed a significant difference and relationship between two experimental groups and control group (P<0.05). The use of cell-free ligamentum plantar matrix showed markedly significant improvement in the processes of joint cartilage repair compared control group (P<0.05). Results support the use of cell-free ligamentum plantar can be useful and promising bio-engineering procedure as a scaffold for the treatment of the articular cartilage surface. Keywords: Cell-free matrix, Ostrich plantar ligament, Repair, Articular cartilage defect, Rabbit Tavşanlarda Artikular Kartilaj Defekt Onarımında Devekuşu Plantar Ligament Kökenli Hücre İçermeyen Matriks Doku Kullanımı ÖzetArtikular kartilaj lezyonları dizin en sıklıkla gözlenen yaralanması olup birkaç onarım metodu tanımlanmıştır. Bu çalışmada devekuşunun dizinden ekstrakte edilen kollajen tip I doku iskelesinin in vivo potansiyeli tanımlanmıştır. Ağırlıkları 1800±100 g olan 7 adet Yeni Zelanda ergin erkek tavşanın her iki femurunda femoral kondulusların ağırlık taşıyan bölgelerinde bilateral olarak tüm kat hasarı oluşturuldu. Altı sol medial kondulus hücre içermeyen doku ile doldurulurken (Grup I) aynı tavşanların altı sağ medial kondulus hasarı hücre içeren doku ile tedavi edildi (Grup II) ve bir tavşanın sağ medial kondulus hasarı tedavi uygulanmayarak kontrol grubu olarak bırakıldı. Histopatoloji bulguları kartilaj onarım belirteçleri olarak hücre morfolojisi, renk matriks ve kartilaj kalınlığı bakımlarından her üç grup arasında anlamlı derecede fark olduğunu gösterdi (P<0.05). Ayrıca, subkondral kemik oluşumu iki deney grubu ile kontrol grubu arasında anlamlı derecede fark olduğunu göstermiştir (P<0.05). Hücre içermeyen ligamentum plantar matriks kullanımının kontrol grubu ile karşılaştırıldığında eklem kartilaj onarımında belirgin derecede iyileşme oluşturduğu gözlemlendi (P<0.05). Elde edilen sonuçlar hücre iç...

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“…Under the light of the latest developments in understanding of biology (5, 6, 7), composition, metabolism, and biomechanical properties of joint cartilage, new researchers on joint cartilage offer hope about biologically, based procedures as alternative to conventional methods (subchondral drilisation, abrasion and spongiolisation) in the treatment of joint injuries and degenerative joint diseases (8,9,14,15,21). Since many different results are reported, the most suitable method in treatment of focal defects is not exactly known (11,16).…”

Section: Introductionmentioning

confidence: 99%

“…In order to have repaired or regenerated cartilage to function as joint tissue sufficiently, normal painless motion synovial joint should be restored. Realization of this requires that; structure, composition, mechanical properties and strength of the repairing tissue should be similar to the surface of natural joint (11,19,20). Under the light of the latest developments in understanding of biology (5, 6, 7), composition, metabolism, and biomechanical properties of joint cartilage, new researchers on joint cartilage offer hope about biologically, based procedures as alternative to conventional methods (subchondral drilisation, abrasion and spongiolisation) in the treatment of joint injuries and degenerative joint diseases (8,9,14,15,21).…”

Section: Introductionmentioning

confidence: 99%

Kronik böbrek yetmezliği belirtileri gösteren kedilerde biyokimyasal ve hematolojik değişiklikler

Altintaş¹,

Üren²,

Pekcan³

et al. 2006

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Özet: Araştırmada, kronik böbrek yetmezliği (KBY) gözlenen kedilerde hematolojik ve biyokimyasal değişikliklerin incelenmesi ve bulguların hastalığın derecelendirilmesinde kullanılması amaçlanmıştır. KBY tespit edilen ve yaşları 3-12 arasında değişen 22 dişi kedi ile aynı yaşlarda ve klinik olarak sağlıklı görünen 10 dişi kedi (kontrol) araştırmanın hayvan materyalini oluşturmuştur. Hayvanlara ait idrar örneklerinde protein varlığı ve dansite; kan örneklerinde hemoglobin, hematokrit değer, alyuvar ve akyuvar sayıları ile akyuvarların % dağılımları; serum örneklerinde ise toplam protein, üre, kreatinin, sodyum, potasyum, kalsiyum, fosfor, osteokalsin (OC), toplam ALP (t-ALP) ve kemik spesifik ALP (k-ALP) değerleri ölçülmüştür. KBY'li kedilerde poliüri, idrar dansitesinde düşüş, azotemi, hipokalemi, hiponatremi, hiperfosfatemi, hiperproteinemi, normositik normokromik anemi ve akyuvar artışı saptanmış; serum osteokalsin değerleri hasta ve kontrol grupta ölçüm sınırlarının altında (<1ng/ml) bulunmuştur. Kan serumunda üre ve kreatinin değerlerinin KBY'li kedilerde "üremi" düzeylerine (320.7±38.5 mg/dl) yükseldiği (p<0.001); kreatinin değer-lerinin de (6.77±0.75 mg/dl) hastalığın ciddi boyutlarda olduğunu gösterdiği saptanmıştır. Serum Na ve K değerlerinin hasta kedilerde önemli derecede düştüğü (p<0.05); Ca değerlerinde istatistik önemli bir değişiklik gözlenmezken (p>0.05) Pi değerlerinin önemli derecede (p<0.001) artış gösterdiği (hiperfosfatemi) saptanmış ve değişiklikler glomeruler filtrasyon hızında düşüş ve tubuler geri emilimde bozukluk ile ilişkilendirilmiştir. İncelenen parametreler kümeleme testi ile değerlendirilerek kedilerde KBY (1+)-(3+) arasında derecelendirilmiş ve 4 hastada şiddetli, 9 hastada orta ve geri kalan 9 hastada ise hafif seyrettiği saptanmıştır. Kan hematokrit yüzdesi ve alyuvar sayısındaki önemli düşüşler (p<0.01) KBY ile uyumlu bulunmuştur (normositik normokromik anemi) ve akyuvar sayısındaki artış olası bir sekonder enfeksiyona bağlanmıştır. Kan hemoglobin değerlerindeki düşüş belirgin olmasına rağmen istatistik önemli bulunmamıştır (p>0.05). Serum t-ALP ve k-ALP düzeylerindeki önemli düşüşler; Ca/P dengesindeki bozukluk ve düşük osteokalsin düzeyleri kemik metabolizmasının kronik yetmezlikten henüz belirgin şekilde etkilenmediği yönünde değer-lendirilmiştir.Anahtar sözcükler: Biyokimyasal belirtiler, hematolojik belirtiler, kedi, kronik böbrek yetmezliği. Biochemical and hematological changes in cats with chronic renal failureSummary: In this study, it is aimed to evaluate the bone metabolism, biochemical and haematological changes of cats with chronic renal failure. 22 female cats aging between 3-12 years with Chronic Renal Failure (CRF) and for control group 10 clinicaly healty female cats aging nearly the same with the patients constituted the research's animal material. Urine samples densities were determined and assayed for the presence of protein. Blood count and total protein, urea, creatinine, sodium, potassium, calcium, phosphorus, osteocalcine, total ALP and bone ALP assays h...

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Cartilage repair: A critical review

Cited by 169 publications

References 31 publications

Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review

Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review

Tavşanlarda Artikular Kartilaj Defekt Onarımında Devekuşu Plantar Ligament Kökenli Hücre İçermeyen Matriks Doku Kullanımı

Kronik böbrek yetmezliği belirtileri gösteren kedilerde biyokimyasal ve hematolojik değişiklikler

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