Glucosyl Hesperidin Lowers Serum Triglyceride Level in Hypertriglyceridemic Subjects through the Improvement of Very Low-Density Lipoprotein Metabolic Abnormality

Miwa, Yoshikatsu; Mitsuzumi, Hitoshi; Sunayama, Takahiro; Yamada, Mika; Okada, Katsuhide; Kubota, Michio; Chaen, Hiroto; Mishima, Yasuo; Kibata, Masayoshi

doi:10.3177/jnsv.51.460

Cited by 67 publications

(61 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The accumulation of these TG-rich lipoproteins in serum is considered to be caused by an imbalance of the synthesis and catabolism of VLDL, namely, VLDL metabolic abnormality (12)(13)(14). In the previous clinical study, we have found that G-hesperidin administration reduced serum VLDL and remnant lipoproteins in the hypertriglyceridemic subjects ( 11 ). From this result, it is suggested that the TG-lowering effect of G-hesperidin is due to the improvement of VLDL metabolic abnormality.…”

Section: Discussionmentioning

confidence: 95%

“…In addition, G-hesperidin administration significantly decreased an elevated serum apolipoprotein B (apo B) level in hypertriglyceridemic subjects ( 11 ). It has been demonstrated that apo B forms VLDL by complexing with TG and cholesteryl ester (CE) in hepatocytes and is secreted from the liver (15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

“…This result indicates that G-hesperidin preferentially down-regulates the cell responses augmented by oleate stimula- tion. In the previous clinical study, G-hesperidin was effective in the hypertriglyceridemic subjects and significantly lowered their serum TG and apo B levels, but it had no effect on the normal subjects (11). Hypertriglyceridemic patients have been reported to experience an increase in VLDL secretion by excess influx of fatty acids, which consist mainly of oleic acid, into the liver (39).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Suppression of Apolipoprotein B Secretion from HepG2 Cells by Glucosyl Hesperidin

Miwa

Mitsuzumi

Yamada

et al. 2006

J Nutr Sci Vitaminol

Self Cite

View full text Add to dashboard Cite

SummaryOur previous study has shown that a soluble hesperidin derivative, glucosyl hesperidin (G-hesperidin), preferentially lowers serum triglyceride (TG) level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein (VLDL) metabolic abnormality. G-Hesperidin has also been found to decrease an elevated serum apolipoprotein B (apo B) level in the hypertriglyceridemic subjects, suggesting a possibility that this compound suppresses excess VLDL secretion in the liver. In the present study, to gain a better understanding of possible mechanisms by which G-hesperidin lowers serum TG, we examined whether this derivative affects apo B secretion from HepG2 human hepatoma cells, a model of hepatic VLDL secretion. As a result, G-hesperidin significantly reduced apo B secretion from the oleate-stimulated HepG2 cells. Furthermore, G-hesperidin significantly suppressed apo B secretion only in the oleate-stimulated cells and failed to act on the cells incubated without oleate. In the oleate-stimulated cells, G-hesperidin significantly decreased cellular cholesteryl ester (CE), although it had no effect on cellular TG or free cholesterol amounts. Moreover, the oleate-stimulated cells had a decrease in cellular apo B amounts by G-hesperidin exposure. These findings indicate that G-hesperidin downregulates the assembly of apo B-containing lipoproteins via the reduction of CE synthesis augmented with oleate and results in suppressing excess apo B secretion from the cells. This effect is speculated to be associated with the improvement of VLDL metabolic abnormality in hypertriglyceridemic subjects and considered as a mechanism of lowering serum TG. Key Words glucosyl hesperidin, very low-density lipoprotein, apolipoprotein B, cholesteryl ester, HepG2 cells Hesperidin, a citrus flavonoid, is well known to decrease capillary fragility and permeability ( 1 ). This compound has also been reported to have various physiological activities including antioxidant effect ( 1 ), antihypertensive effect ( 2 ) and antiallergic effect ( 3 ). Therefore, hesperidin has attracted attention as a multifunctional food ingredient. However, the use of this flavonoid in the field of foods has been limited because of its low water solubility.To solve this problem, Hijiya and Miyake have synthesized a soluble derivative of hesperidin, glucosyl hesperidin (G-hesperidin), by regioselective transglycosylation with cyclodextrin glucanotransferase from Bacillus stearothermophilus (Fig. 1) ( 4 ). G-Hesperidin is very soluble in water, and its solubility is about 10,000 times greater than that of conventional hesperidin ( 4 ). Moreover, it has been verified that this derivative releases hesperidin through hydrolysis by brush border ␣ -glucosidases ( 4 , 5 ). Our recent studies have shown that Ghesperidin as well as hesperidin exhibits such physiological activities as decrease of serum lipid peroxide level in hyperlipidemic mice ( 6 ), antihypertensive effect on spontaneously hypertensive rats ( 7 , 8 ) and suppression of passive ...

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Suppression of Apolipoprotein B Secretion from HepG2 Cells by Glucosyl Hesperidin

Miwa

Mitsuzumi

Yamada

et al. 2006

J Nutr Sci Vitaminol

Self Cite

View full text Add to dashboard Cite

show abstract

“…6,31) In a human study, no clinical changes related to 24-week administration of G-hesperidin were observed in subjects. 32) Hence the safety of G-hesperidin is considered to be comparable to that of hesperidin. Additionally, we observed that the metabolites, such as hesperetin, hesperidin, and their conjugates, were rapidly excreted in rat urine after administration of G-hesperidin (Fig.…”

Section: Discussionmentioning

confidence: 99%

Bioavailability of Glucosyl Hesperidin in Rats

Yamada

Tanabe

Arai

et al. 2006

Bioscience, Biotechnology, and Biochemistry

Self Cite

120

View full text Add to dashboard Cite

“…Hesperidin is a flavone abundantly found in citrus fruit peel. Glucosyl hesperidin has been shown to reduce serum TG in several animal models (5,6) and in subjects with hypertirglyceridemia (7,8). Glucosyl hesperidin plus caffeine is effective for controlling obesity mediated by the inhibition of hepatic lipogenesis (9).…”

Section: Discussionmentioning

confidence: 99%

Extracts of <i>citrus Sudachi</i> peel attenuate body weight gain in C57BL/6 mice fed a high-fat diet

et al. 2017

View full text Add to dashboard Cite

: Citrus Sudachi is the special local product of Tokushima Prefecture, and over 98% % of Sudachi consumed in Japan every year is produced in Tokushima Prefecture. In this study, we evaluated the function of sudachi peel extract (SPE) using an animal model of obesity. C57BL/6 mice were fed a high-fat diet containing 1% % SPE powder. Treatment with SPE significantly decreased body weight compared to that of mice fed a high-fat diet. A significant difference in body weight was observed between the control and SPE groups from 7 weeks after the start of the experiment, the significant difference continued until the end of the 14-week experiment. Reduction of blood glucose levels following insulin administration in SPE-treated mice was grater than that in control mice. Determination of mRNA expression in adipose tissue showed that the expression level of TNF-α in the SPE group was significantly decreased compared to that on the control group. These results suggest that SPE potentially has the ability to attenuate body weight gain.

show abstract

Glucosyl Hesperidin Lowers Serum Triglyceride Level in Hypertriglyceridemic Subjects through the Improvement of Very Low-Density Lipoprotein Metabolic Abnormality

Cited by 67 publications

References 40 publications

Suppression of Apolipoprotein B Secretion from HepG2 Cells by Glucosyl Hesperidin

Suppression of Apolipoprotein B Secretion from HepG2 Cells by Glucosyl Hesperidin

Bioavailability of Glucosyl Hesperidin in Rats

Extracts of <i>citrus Sudachi</i> peel attenuate body weight gain in C57BL/6 mice fed a high-fat diet

Contact Info

Product

Resources

About