Extracts of &lt;i&gt;citrus Sudachi&lt;/i&gt; peel attenuate body weight gain in C57BL/6 mice fed a high-fat diet

Kobayashi, Hitomi; Mitani, Mami; Minatogawa, Yuka; Hayashi, Satoko; Nakamoto, Mariko; Shuto, Emi; Nii, Yoshitaka; Sakai, Tohru

doi:10.2152/jmi.64.20

Cited by 8 publications

(5 citation statements)

References 14 publications

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“…However, there were no significant differences in total food and calorie intakes between HFDC-LL and HFD-LL mice. Previously, it has been reported that dietary intake of grapefruit (Citrus paradisi) (15), Citrus unshiu (16), Citrus bergamia (17), Cit- rus sunki (18), Citrus sudachi (19), and Citrus junos (20) suppressed body weight, body fat, blood TG, and T-CHO in obese mouse models. These studies showed that hesperidin, neohesperidin, nobiletin, tangeretin, and naringin have critical roles in the effects (15)(16)(17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Dietary Intake of Immature <i>Citrus tumida</i> Hort. ex Tanaka Peels Suppressed Body Weight Gain and Fat Accumulation in a Mouse Model of Acute Obesity

Satô

Goto

Inoue

et al. 2019

Journal of Nutritional Science and Vitaminology

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Citrus fruits have several potential benefits for maintaining our health. In this study, we investigated the anti-obesity effects of immature Citrus tumida hort. ex Tanaka (C. tumida) peels using an acute obesity mice model. C57BL/6J male mice were divided into 2 groups; HFD-LL subjected to a high fat diet (HFD) and constant light exposure (LL), and HFDC-LL subjected to a HFD containing immature peel powder of C. tumida (5% w/w) and LL. Dietary ingestion of immature C. tumida peels significantly suppressed body weight gain following decreased epidydimal, perirenal, and subcutaneous fat weights. Blood levels of triglyceride and total cholesterol in the HFDC-LL were significantly lower than those in the HFD-LL group; however, there was no significant difference in food or calorie intake between the 2 groups. These results suggested that immature C. tumida peels have a beneficial effect on the prevention of obesity and metabolic syndrome via its biochemical activities of lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

Dietary Intake of Immature <i>Citrus tumida</i> Hort. ex Tanaka Peels Suppressed Body Weight Gain and Fat Accumulation in a Mouse Model of Acute Obesity

Satô

Goto

Inoue

et al. 2019

Journal of Nutritional Science and Vitaminology

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“…This extract was rich in phenolic compounds that are known to posses several actions to improve glucose tolerance as reported below. The in vivo reduction of blood glucose and plasma insulin levels was demonstrated for both Citrus reticulata and Citrus sudachi peels extract (Guo et al, 2016;Kobayashi et al, 2017). In particular, Citrus sudachi exerted its effect via reduction of TNF-α mRNA expression.…”

Section: Antibacterial Potentialmentioning

confidence: 95%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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Citrus is the most cultivated fruit crop in the world and occupies a place of considerable importance in the country’s economy. Almost 33% of the citrus fruits are processed for juice production; however, a great amount of wastes, including peels, segment membranes, and seeds are also produced. Indeed, citrus fruits consist of 45% juice, 26% pulp, 27% peels, and 2% seeds. Pruning, a cultural practice involving the removal of tree branches and limbs, was applied to improve fruit’s quality. A large amount of leaves are produced through pruning. These agri-food matrices contain a wide range of bioactive phytochemicals compared to fruits. The present review covers the past 5 years of research carried out in chemistry, health properties, and applications in food and nutraceutical industries of all portions of citrus fruit and its major bioactive compounds. Additionally, patents are also included.

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“…It has been widely reported that citrus fruit or citrus peel extract has potential antiobesity properties. − Previous studies indicate that citrus fruits contain numerous bioactive compounds such as alkaloids, limonoids, phenolic acids, flavanone glycosides, polymethoxylated flavones (PMFs), and its derivatives. Furthermore, Sayuri Inafuku-Teramoto et al reported that immature citrus fruits usually have higher levels of functional phytochemicals (e.g., p -synephrine, flavanone glycosides, and PMFs) than mature fruits. − In this study, we found that some major phytochemicals in ICRE are p -synephrine, narirutin, hesperidin, nobiletin, and tangeretin (Table ).…”

Section: Discussionmentioning

confidence: 99%

Immature Citrus reticulata Extract Promotes Browning of Beige Adipocytes in High-Fat Diet-Induced C57BL/6 Mice

Chou

Pan

2018

J. Agric. Food Chem.

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Obesity has become a global public health issue. Promoting browning of white adipose tissue (WAT) helps to maintain energy homeostasis. Previous studies have found that citrus fruit exhibits a number of biological activities. Although most citrus fruit drop has been considered agricultural waste, the ability to use it may be desirable. In this study, we investigate the antiobesity effects of immature citrus fruits in high-fat diet (HFD)-fed mice. The main phytochemical components of immature Citrus reticulata in water extraction analyzed by HPLC are synephrine, narirutin, hesperidin, nobiletin, and tangeretin (16.0 ± 1.08, 4.52 ± 0.31, 9.14 ± 0.32, 2.54 ± 0.07, 1.67 ± 0.05 mg/g, respectively). Oral administration of 1% immature Citrus reticulata extract (ICRE) for 11 weeks markedly reduced body weight gain, epididymal fat weight, fasting blood glucose, serum triglyceride, and total cholesterol ( P < 0.05 for all). In addition, histological analysis revealed that dietary ICRE decreased adipocyte size and hepatic steatosis compared to the HFD group ( P < 0.05 for both). Furthermore, we found that mice treated with ICRE have improved cold tolerance during acute cold challenge. These effects were associated with increased expression of uncoupling protein 1 (UCP1) and thermogenic genes in inguinal WAT. Taken together, these results suggest that ICRE can prevent obesity and lipid accumulation through induction of brown-like adipocyte formation.

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Extracts of <i>citrus Sudachi</i> peel attenuate body weight gain in C57BL/6 mice fed a high-fat diet

Cited by 8 publications

References 14 publications

Dietary Intake of Immature <i>Citrus tumida</i> Hort. ex Tanaka Peels Suppressed Body Weight Gain and Fat Accumulation in a Mouse Model of Acute Obesity

Dietary Intake of Immature <i>Citrus tumida</i> Hort. ex Tanaka Peels Suppressed Body Weight Gain and Fat Accumulation in a Mouse Model of Acute Obesity

Citrus species: Modern functional food and nutraceutical-based product ingredient

Immature Citrus reticulata Extract Promotes Browning of Beige Adipocytes in High-Fat Diet-Induced C57BL/6 Mice

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