Glucosyl Hesperidin Improves Serum Cholesterol Composition and Inhibits Hypertrophy in Vasculature

Abstract

Long-term administration of hesperidin (HES) or glucosyl hesperidin (GHES), a water-soluble analogue of HES, brings about an antihypertensive effect on spontaneously hypertensive rats (SHR). In the present study, we investigated the effects of long-term admin istration of HES and GHES (corresponding to 30mg/d/kg body weight) on serum lipid con centration and morphology of vasculature. Serum HDL cholesterol increased in both SHR and Wistar-Kyoto rats (WKY) fed a HES-or GHES-containing diet for 25wk. Simulta neously, GHES administration reduced the vascular diameter and media-intimal cross-sec tional area of the abdominal aorta in SHR. These results suggest that HES as well as GHES improves serum cholesterol composition and that GHES inhibits hypertrophy in vasculature as well.

Bioavailability of Glucosyl Hesperidin in Rats

“…G-Hesperidin, a water-soluble derivative of hesperidin, has been shown to exhibit the same biological activities as hesperidin in vivo, [7][8][9] but the behavior of this derivative in the body remains to be fully clarified. In this study, we compared the metabolic fate and the bioavailability of G-hesperidin with those of hesperidin in rats.…”

“…6) Moreover, it has been confirmed that the biological activities of G-hesperidin are the same or more than those of hesperidin. [7][8][9] Nishizaki et al reported that G-hesperidin and hesperidin dose-dependently inhibited passive cutaneous anaphylaxis in rats, and that the effect of G-hesperidin was more continuous than that of hesperidin. 7) Furthermore, Chiba et al showed that Ghesperidin and hesperidin significantly prevented bone loss in the femur in ovariectomized mice.…”

Glucosyl Hesperidin Lowers Serum Triglyceride Level in Hypertriglyceridemic Subjects through the Improvement of Very Low-Density Lipoprotein Metabolic Abnormality

“…Our recent studies have shown that G-hesperidin as well as hesperidin exhibits such physiological activities as decrease of serum lipid peroxide level in hyperlipidemic mice (6), antihypertensive effect on spontaneously hypertensive rats ( 7,8) and suppression of passive cuta neous anaphylaxis in rats (9). These findings indicate that G-hesperidin behaves as hesperidin in the body and results in the exhibition of physiological activities.…”

Anti-oxidative effects of citro flavonoids on spermatogenesis in rat

“…A wide range of different biological activities, including antibacterial, antithrombotic, vasodilatory, antiinflammatory, and anticarcinogenic effects mediated by different mechanisms, are associated with flavonoid compounds (Middleton et al, 2000). Hesperidin reduced cholesterol and blood pressure (Ohtsuki et al, 2003) in rats. In a mouse study, large doses of the glucoside hesperidin decreased bone density loss (Chiba et al, 2003).…”