Glucosebelastungen und Arginin-Infusionen bei Neugeborenen. Einflu� auf Wachstumshormon, Blutzucker, Fetts�uren und Glycerin

Stubbe, P; Wolf, Harald; Stolte, Gisela; Lausmann, S

doi:10.1007/bf01487631

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…In fetal monkeys Mintz [13] found neither GH stimulation by arginine or tolbutamide nor any suppression by glucose loads. In contrast newborn humans show a stimulation of GH secretion after arginine [18] or insulin induced hypoglycemia [6]. Kaplan and Grumbach [12] concluded that there is an uninhibited GH secretion in fetal life which slowly changes during the perinatal period into the adult regulatory pattern.…”

Section: Discussionmentioning

confidence: 99%

“…Westphal [20] assumed that in the newborn hyperglycemia leads to Gtt secretion which activates protein synthesis. According to Stubbe [18] the postnatal protein synthesis begins at a time when there is normally no paradoxical GH reaction.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast Stubbe [18] found a fall in GH levels after the intravenous injection of glucose. In all these studies there has been a wide variation between individual results.…”

Section: Introductionmentioning

confidence: 88%

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The paradoxical growth hormone reaction after intravenous glucose in the newborn

et al. 1974

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Abstract. Intravenous glucose tests (0.5 g/kg body weight) were performed in 13 newborn infants during their first 3 days of life. The variations in blood glucose, insulin and GH values were studied. In all patients there was a rise in plasma insulin. The correlation between initial insulin rise and glucose assimilation constant was 0.503 which is almost significant. The glucose load provoked a very variable response in plasma GH concentration, some infants showed a rise, others a fall. If the newborns were grouped according to this reaction it appeared that the GK response could be explained using Wilder's law of initial value. This hypothesis, however, did not stand up to a thorough statistical analysis including a discussion of a less well-known statistical error.In contrast to insulin secretion, GH apparently plays no major role in the short term regulation of the blood sugar in the newborn.Key words: Growth hormone --Newborn --Glucose load --Insulin. ExtractAn intravenous glucose load Jn 13 newborns showed a high glucose assimilation constant (k) of 4.81 j: 1.39. A positive correlation (r = 0.503) was found between k and the rise of insulin concentration within 2 min after injection of glucose. Plasma GH (growth hormone) concentrations varied widely with a high mean initial value (48.3 ng/ml), and no distinct pattern (neither a fall nor an increase) was provoced by glucose load. There was no correlation between variations of GH concentration and glucose assimilation. The present study suggests that the regulation of GIt secretion is not yet established in the early postnatal period. Therefore an increase in GIt concentration after glucose load is a coincidence rather than a "paradoxical" reaction. SpeculationRegulation of GH secretion based on negative correlation between blood glucose and GH concentration becomes effective only in the late 64 P.W. Nars et al.neonatal period. Because the mean levels of GH concentration are very high in the early postnatal period variations in GH concentrations do not affect glucose assimilation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The paradoxical growth hormone reaction after intravenous glucose in the newborn

et al. 1974

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“…The lower time limit was chosen to avoid the first intense period of metabolic adaptation after birth. The upper time limit was set at 24 hours, since after this time the difference in k-value at IVGTT between infants of diabetic mothers and those of healthy mothers has been reported to diminish [20,26]. In the remaining 5 infants the IVGTT could not be performed within those time limits.…”

Section: Infantsmentioning

confidence: 99%

Infants of mothers with a high and of mothers with a low insulin response to glucose infusion. Glucose tolerance, insulin response and clinical appearance during the early neonatal period

Edström¹,

Thalme²

1975

Journal of Perinatal Medicine

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Diabetes mellitus in a pregnant woman affects the development of the fetal pancreas [2] resulting in hyperinsulinism of the newborn infant who also often presents typical clinical traits [8,23, 32], Furthermore, diabetic women may produce large-for-date infants long before their disturbed carbohydrate metabolism is diagnosed [13,17]. It is not known, however, at which stage in the development of diabetes this effect on the fetus appears. CERASI and LUFT [4,5] have defined "prediabetes" äs a stage in which there is a normal glucose tolerance but a decreased insulin response to glucose infusion (GIT). In a previous study [6] it was demonstrated that in a group of low insulin responders -in which the prediabetic individuals can be expected to be found -the glucose tolerance remained normal throughout pregnancy, while the insulin response increased gradually. The glucose tolerance and insulin response to an intravenous glucose load (IVGTT) of the infants borne by these women and by the control group of high responders were studied. These results together with clinical data on the infants and their mothers are presented here.

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Control of Glucose Metabolism in the Human Fetus and Newborn Infant

Adam

1971

Advances in Metabolic Disorders

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Glucosebelastungen und Arginin-Infusionen bei Neugeborenen. Einflu� auf Wachstumshormon, Blutzucker, Fetts�uren und Glycerin

Cited by 7 publications

References 14 publications

The paradoxical growth hormone reaction after intravenous glucose in the newborn

The paradoxical growth hormone reaction after intravenous glucose in the newborn

Infants of mothers with a high and of mothers with a low insulin response to glucose infusion. Glucose tolerance, insulin response and clinical appearance during the early neonatal period

Control of Glucose Metabolism in the Human Fetus and Newborn Infant

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