Glucose‐Triggered Insulin Release from Fe<sup>3+</sup>‐Cross‐linked Alginate Hydrogel: Experimental Study and Theoretical Modeling

Scheja, Sabrina; Domanskyi, Sergii; Gamella, María; Wormwood, Kelly L.; Darie, Costel C.; Poghossian, Arshak; Schöning, Michael J.; Melman, Artem; Privman, Vladimir; Katz, Evgeny

doi:10.1002/cphc.201700195

Cited by 22 publications

(20 citation statements)

References 72 publications

(134 reference statements)

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“…where

𝒟_{F, 0} = 1.5 \times 10^{- 6} c m^{2} s^{- 1}

is the diffusion coefficient of F‐DNA in water, taken as a typical value;

𝒟_{F} = 0.97 \times 10^{- 11} c m^{2} s^{- 1}

is the diffusion coefficient of the same molecules inside fully cross‐linked alginate;

W_{0}

is the crosslinking density of the intact alginate. The diffusion coefficient of F‐DNA in the intact cross‐linked gel was also taken from the same as in the earlier work . With these assumptions, the calculated F‐DNA leakage curve, Figure (a), is a in good agreement with the experimental data.…”

Section: Resultssupporting

confidence: 59%

“…Here, we use the same expression and the same parameter values as in an earlier study of a different alginate system. The crosslinking density is inversely proportional to the void sizes in alginate .…”

Section: Resultsmentioning

confidence: 99%

“…As this density,

W (r, t)

, which is initially

W_{0} = 0.85 m M

, decreases, the diffusion coefficient of the entrapped F‐DNA increases. Here we take

true 𝒟 (() r, t) = 𝒟_{F, 0} - (() 𝒟_{F, 0} - 𝒟_{F}) {([], \frac{W (r, t)}{W_{0}})}^{\frac{1}{3}},

…”

Section: Resultsmentioning

confidence: 99%

“…Alginate hydrogels cross‐linked with Ca 2+ cations can be only used for slow release processes . Recently, another kind of alginate hydrogel, cross‐linked with Fe 3+ ‐cations has been investigated for signal‐triggered release of entrapped species . While our previous study was performed using alginate beads, the present work addresses the signal‐release process from a thin‐film electrochemically deposited on an electrode surface.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, another kind of alginate hydrogel, cross‐linked with Fe 3+ ‐cations has been investigated for signal‐triggered release of entrapped species . While our previous study was performed using alginate beads, the present work addresses the signal‐release process from a thin‐film electrochemically deposited on an electrode surface. This process is based on a special property of such alginate, which is that only Fe 3+ cations facilitate alginate cross‐linking, whereas Fe 2+ cations do not cross‐link alginate.…”

Section: Introductionmentioning

confidence: 99%

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Biomolecular Release from Alginate‐modified Electrode Triggered by Chemical Inputs Processed through a Biocatalytic Cascade – Integration of Biomolecular Computing and Actuation

et al. 2017

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Biocatalytic cascades involving more than one or two enzyme‐catalyzed step are inefficient inside alginate hydrogel prepared on an electrode surface. The problem originates from slow diffusion of intermediate products through the hydrogel from one enzyme to another. However, enzyme activity can be improved by surface immobilization. We demonstrate that a complex cascade of four consecutive biocatalytic reactions can be designed, with the enzymes immobilized in an LBL‐assembled polymeric layer at the alginate‐modified electrode surface. The product, hydrogen peroxide, then induces dissolution of iron‐cross‐linked alginate, which results in release process of entrapped biomolecular species, here fluorescently marked oligonucleotides, denoted F‐DNA. The enzymatic cascade can be viewed as a biocomputing network of concatenated AND gates, activated by combinations of four chemical input signals, which trigger the release of F‐DNA. The reactions, and diffusion/release processes were investigated by means of theoretical modeling. A bottleneck reaction step associated with one of the enzymes was observed. The developed system provides a model for biochemical actuation triggered by a biocomputing network of reactions.

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“…where

𝒟_{F, 0} = 1.5 \times 10^{- 6} c m^{2} s^{- 1}

is the diffusion coefficient of F‐DNA in water, taken as a typical value;

𝒟_{F} = 0.97 \times 10^{- 11} c m^{2} s^{- 1}

is the diffusion coefficient of the same molecules inside fully cross‐linked alginate;

W_{0}

Section: Resultssupporting

confidence: 59%

Section: Resultsmentioning

confidence: 99%

“…As this density,

W (r, t)

, which is initially

W_{0} = 0.85 m M

, decreases, the diffusion coefficient of the entrapped F‐DNA increases. Here we take

true 𝒟 (() r, t) = 𝒟_{F, 0} - (() 𝒟_{F, 0} - 𝒟_{F}) {([], \frac{W (r, t)}{W_{0}})}^{\frac{1}{3}},

…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Biomolecular Release from Alginate‐modified Electrode Triggered by Chemical Inputs Processed through a Biocatalytic Cascade – Integration of Biomolecular Computing and Actuation

et al. 2017

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Release of Molecular Species Stimulated by Logically Processed Biomolecule Signals

2019

Enzyme‐Based Computing Systems

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Dual‐responsive shape memory hydrogels with self‐healing and dual‐responsive swelling behaviors

Yang¹,

Gao²,

Zhao

et al. 2020

J of Applied Polymer Sci

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Shape memory hydrogels (SMHs) can fix the hydrogels in a provisional shape and restore the initial shape under external stimulation. Herein, a dualresponsive shape memory hydrogel with dual-responsive swelling and selfhealing properties is presented in this work. The SMHs were fabricated by one-step emulsion copolymerization of acrylic acid (AAc), acrylamide (AAm) and stearyl methacrylate (SMA). Sodium alginate (SA) was introduced as an interpenetrating polymer in the network. With ionic cross-linking between-COO − and Fe 3+ or saline-reinforced hydrophobic association, the hydrogels

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Glucose‐Triggered Insulin Release from Fe³⁺‐Cross‐linked Alginate Hydrogel: Experimental Study and Theoretical Modeling

Cited by 22 publications

References 72 publications

Biomolecular Release from Alginate‐modified Electrode Triggered by Chemical Inputs Processed through a Biocatalytic Cascade – Integration of Biomolecular Computing and Actuation

Biomolecular Release from Alginate‐modified Electrode Triggered by Chemical Inputs Processed through a Biocatalytic Cascade – Integration of Biomolecular Computing and Actuation

Release of Molecular Species Stimulated by Logically Processed Biomolecule Signals

Dual‐responsive shape memory hydrogels with self‐healing and dual‐responsive swelling behaviors

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Glucose‐Triggered Insulin Release from Fe3+‐Cross‐linked Alginate Hydrogel: Experimental Study and Theoretical Modeling

Cited by 22 publications

References 72 publications

Biomolecular Release from Alginate‐modified Electrode Triggered by Chemical Inputs Processed through a Biocatalytic Cascade – Integration of Biomolecular Computing and Actuation

Biomolecular Release from Alginate‐modified Electrode Triggered by Chemical Inputs Processed through a Biocatalytic Cascade – Integration of Biomolecular Computing and Actuation

Release of Molecular Species Stimulated by Logically Processed Biomolecule Signals

Dual‐responsive shape memory hydrogels with self‐healing and dual‐responsive swelling behaviors

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Product

Resources

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Glucose‐Triggered Insulin Release from Fe³⁺‐Cross‐linked Alginate Hydrogel: Experimental Study and Theoretical Modeling