<scp>Dual‐responsive</scp> shape memory hydrogels with <scp>self‐healing</scp> and <scp>dual‐responsive</scp> swelling behaviors

Yang, Qianyu; Gao, Chen; Zhao, Xuemei; Fu, Yiqing; Tsou, Chi‐Hui; Zeng, Chunyan; Li, Yuan; Pu, Zejun; Xia, Yuhan; Sheng, Yuping; Fang, Yu

doi:10.1002/app.50308

Cited by 9 publications

(3 citation statements)

References 73 publications

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“…The complexation of Fe 3+ with carboxyl groups is redox-sensitive. It was confirmed that carboxyl groups form a stronger complex with Fe 3+ ions than with Fe 2+ [24]. The coordination interactions weaken when iron ions reduced to Fe 2+ , and the mechanical strength of the hydrogel decreases.…”

Section: Results and Discissionmentioning

confidence: 90%

Hydrogels Based on Chitosan and Sodium Alginate with Shape Memory Effect

Bobrina

Illarionova

Salomatina

et al. 2023

MSF

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Hydrogels based on chitosan derivatives, sodium alginate with acrylamide and acrylic acid were obtained by free radical solution copolymerization method in the presence of ammonium persulfate as initiator and urotropin and N,N methylene bisacrylamide as crosslinking agents. The formation of hydrogels was proved by extraction and IR spectroscopy. It is shown that hydrogels are able to fix the temporary form in iron (III) chloride solutions and reclaim it in solutions of ascorbic acid in less than 2 hours. Hydrogels based on sodium alginate have the best physical-mechanical characteristics compared with chitosan-based - the strength reaches 0.7 MPa and 0.11 MPa, the elasticity modulus is 1.02 MPa and 0.17 MPa at 65% deformation, correspondingly.

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Section: Results and Discissionmentioning

confidence: 90%

Hydrogels Based on Chitosan and Sodium Alginate with Shape Memory Effect

Bobrina

Illarionova

Salomatina

et al. 2023

MSF

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“…The relationship between structure and mechanical performances of DPC hydrogels was also studied in our previous investigation. [60] Figure 1 shows the Fourier transform infrared (FTIR) spectra of SA, PAAm, POMA, SAxHA sIPN hydrogels, and SA x HA-Fe 0.2 DPC hydrogels with different SA content. For sIPN and DPC hydrogels, the broad band at 3437-3442 cm −1 corresponds to the absorption peaks of NH 2 derived from PAAm and/or of OH derived from SA.…”

Section: Formation Mechanism and Structure Of Sa X Ha Semi-interpenetrating Network Hydrogels And Sa X Ha-fe Y Dpc Hydrogelsmentioning

confidence: 99%

A Dual Physical Cross‐Linking Strategy to Construct Tough Hydrogels with High Strength, Excellent Fatigue Resistance, and Stretching‐Induced Strengthening Effect

Yang

Gao

Tsou

et al. 2021

Macro Materials & Eng

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Hydrogels with excellent stiffness, toughness, anti‐fatigue, and self‐recovery properties are regarded as promising water‐containing materials. In this work, a dual physically cross‐linked (DPC) sodium alginate (SA)/poly[acrylamide (AAm)‐acrylic acid (AAc)‐octadecyl methacrylate (OMA)]‐Fe3+ hydrogel is reported, which is constructed by hydrophobic association (HA) and ionic coordination (IC). The optimal DPC hydrogel demonstrates excellent mechanical performance: tensile modulus of 0.65 MPa, tensile strength of 3.31 MPa, elongation at break of 1547%, and toughness of 27.8 MJ m–3. SA/P(AAm‐AAc‐OMA)‐Fe3+ DPC hydrogels also exhibit prominent anti‐fatigue and self‐recovery performance (99.1–109.7% modulus recovery and 90.4–108.9% dissipated energy recovery after resting for 5 min without additional stimuli at ambient temperature) through the reconstruction of reversible physical cross‐linking. Some of the SA/P(AAm‐AAc‐OMA)‐Fe3+ DPC hydrogels even exhibit a stretching‐induced strengthening effect, which is similar to the performance of muscle—“the more training, the more strength.” Hence, the combination of HA and IC will provide an effective approach to design DPC hydrogels with desirable mechanical performances and a longer service life for wider applications of soft materials.

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“…Hydrogels are versatile soft materials that have been thoroughly investigated as replacement for biological tissues such as cartilage, − as well as for soft robotics and actuator applications. − Their microstructural resemblance to soft tissue, biocompatibility, and potential tunability of surface and bulk properties are key advantages that advent this field of research. However, conventional single-network (SN) hydrogels are relatively weak and brittle with several orders of magnitude lower fracture toughness than human tissues, including cartilage. , Thus, there is a need for the design of mechanically stronger hydrogels, while possessing tunable surface and bulk properties for in situ or ex situ control. Double-network (DN) hydrogels are one potential solution to this problem as they generally have stronger mechanical strength than SN hydrogels. , Furthermore, the presence of intrinsic charge introduces the possibility of responsive behavior to external stimuli , as well as high lubricity. , …”

Section: Introductionmentioning

confidence: 99%

Intrinsic and Extrinsic Tunability of Double-Network Hydrogel Strength and Lubricity

Lee

Espinosa‐Marzal

2023

ACS Appl. Mater. Interfaces

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Double-network (DN) hydrogels are promising materials for tissue engineering due to their biocompatibility, high strength, and toughness, but understanding of their microstructure−property relationships still remains limited. This work investigates a DN hydrogel comprising a physically crosslinked agarose, as the first network, and a chemically crosslinked copolymer with a varying ratio of acrylamide and acrylic acid, as the second network. The charge, intrinsic to most DN hydrogels, introduces a responsive behavior to chemical and electrical stimuli. The DN strengthens agarose hydrogels, but the strengthening decreases with the swelling ratio resulting from increasing acrylic acid content or reducing salt concentration. Through careful imaging by atomic force microscopy, the heterogenous surface structure and properties arising from the DN are resolved, while the lubrication mechanisms are elucidated by studying the heterogeneous frictional response to extrinsic stimuli. This method reveals the action of the first (agarose) network (forming grain boundaries), copolymer-rich and poor regions (in grains), charge and swelling in providing lubrication. Friction arises from the shear of the polymeric network, whereas hydrodynamic lift and viscoelastic deformation become more significant at higher sliding velocities. We identify the copolymer-rich phase as the main source of the stimulus-responsive behavior. Salt concentration enhances effective charge density and reduces viscoelastic deformation, while electric bias swells the gel and improves lubrication. This work also demonstrates the dynamic control of interfacial properties like hydrogel friction and adhesion, which has implications for other areas of study like soft robotics and tissue replacements.

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Dual‐responsive shape memory hydrogels with self‐healing and dual‐responsive swelling behaviors

Cited by 9 publications

References 73 publications

Hydrogels Based on Chitosan and Sodium Alginate with Shape Memory Effect

Hydrogels Based on Chitosan and Sodium Alginate with Shape Memory Effect

A Dual Physical Cross‐Linking Strategy to Construct Tough Hydrogels with High Strength, Excellent Fatigue Resistance, and Stretching‐Induced Strengthening Effect

Intrinsic and Extrinsic Tunability of Double-Network Hydrogel Strength and Lubricity

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