Glucose transporter 3 performs a critical role in mTOR-mediated oncogenic glycolysis and tumorigenesis

Zhang, Yanbin; Wei, Can; Xi, Junhua; Tang, Zhiguo; Liang, Chaozhao

doi:10.3892/ol.2015.3075

Cited by 3 publications

(3 citation statements)

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“…mTOR controls glucose transporter expression in several tissues, including the liver. 30 Two glucose transporters in particular mediate glucose homeostasis [ie, SLC2A1 (GLUT1) and SLC2A4 (GLUT4)] ( Figure 2). SLC2A4 is a highly efficient glucose transporter expressed in the liver, adipose tissue, skeletal muscle, and cardiac muscle.…”

Section: Mtor and Glucose Metabolismmentioning

confidence: 99%

“…The American Journal of Pathologyajp.amjpathol.org via the insulin receptor signaling pathway and aids in the response to glucose levels in brown adipose tissue. 30 SLC2A1, on the other hand, is ubiquitously expressed, but functions similarly to SLC2A4 in that it promotes glucose uptake into cells. SLC2A1 is directly up-regulated by MTORC2 through SGK1 signaling ( Figure 2).…”

Section: Mtor and Glucose Metabolismmentioning

confidence: 99%

“…In an mTORregulated process, BAT uses glucose from the periphery for heat generation, which can influence overall blood glucose stores. 30 Indeed, the expression of SLC2A4 on BAT directly correlates with thermogenesis. This process is directly opposed by insulin, specifically in BAT and some types of WAT.…”

Section: Energy Storage and Use In Wat And Batmentioning

confidence: 99%

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Mammalian Target of Rapamycin

Wipperman

Montrose

Gotto

et al. 2019

The American Journal of Pathology

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The complex relationship between diet and metabolism is an important contributor to cellular metabolism and health. Over the past few decades, a central role for mammalian target of rapamycin (mTOR) in the regulation of multiple cellular processes, including the response to food intake, maintaining homeostasis, and the pathogenesis of disease, has been shown. Herein, we first review our current understanding of the biochemical functions of mTOR and its response to fluctuations in hormone levels, like insulin. Second, we highlight the role of mTOR in lipogenesis, adipogenesis, b-oxidation of lipids, and ketosis of carbohydrates, lipids, and proteins. Special attention is paid to recent advances in mTOR signaling in white versus brown adipose tissues. Finally, we review how mTOR regulates cardiovascular health and disease. Together, these insights define a clearer picture of the connection between mTOR signaling, metabolic health, and disease.

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Section: Mtor and Glucose Metabolismmentioning

confidence: 99%

Section: Mtor and Glucose Metabolismmentioning

confidence: 99%