Glucose Transporter 1 Overexpression in Oral Squamous Cell Carcinoma

Abstract

Methodology: A total of 57 patients, who have been diagnosed with chronic adenotonsillitis and operated for obstruction or infection, were included in the study. Patients were divided into two groups according to their palatine tonsil sizes. Each patient performed voice analysis preoperatively and one month postoperatively, recruiting both objective and subjective methods. F0, jitter % and shimmer % values were assessed with objective methods; while subjective methods evaluated pediatric voice handicap index (pVHI) scores. Pre-and post-operative F0, jitter % and shimmer % values and pVHI scores from each study group were compared. Results: In each study group, pre-and post-operative F0, jitter % and shimmer % values were found to be similar. In Group A, postoperative pVHI scores were found to be significantly reduced (p<0.001). In Group B, however, pre-and postoperatively assessed pVHI scores were similar. Conclusion: Adenotonsillar hypertrophy in children, who underwent adenotonsillectomy, seems to be an important and positively effecting factor on the subjective, but not the objective, parameters of voice.

The Role of Glucose Transporters in Oral Squamous Cell Carcinoma

“…Staining intensity was reported by numerous authors, and although the vast majority of tumours fell into the "moderate" to "high" ranges, there were drastically different findings, with intense staining (IHC score ≥ 3) of GLUT-1 found to range from 0.3% to 63% in eight studies [52,54,56,63,64,72,73,76].…”

“…Estilo et al found that 30.6% of patients had high levels of GLUT-3 expressed, compared to normal tissue [81]. In contrast, Qamar found in a cohort of 60 patients that GLUT-1 was only positive in 10% of smokers but was expressed in 82.7% of non-smokers [64]. Similarly, Choi et al found that smoking status was not associated with GLUT-1 expression.…”

“…Whilst there were differences in methodology and staining thresholds for classification, the majority of patient samples were found to be GLUT-1 positive (1380/1709, 80.7%). There were 11 studies (579 patients) where all samples (100%) demonstrated positive staining for GLUT-1 [27,43,51,52,56,59,61,63,71,72,76,80] and a further 11 studies reported GLUT-1 expression in 70%-98% of tumour samples [23,53,55,60,64,[73][74][75][77][78][79]. GLUT-1 was significantly upregulated in tumours compared to adjacent healthy tissue.…”

“…[23,45,[51][52][53][54][55][56][57][58][59][60][61][62][63][64][66][67][68][70][71][72][73][74][75][76][77][78][79][80].…”

Altered Coagulation Pattern in Different Histological Grades of Squamous Cell Carcinoma

“…The prevalence of SCC is higher in Pakistan and other South East Asian nations. 3 Risk of this cancer is intensified by direct and prolonged exposure to sunlight. 4 Patients presenting with squamous cell carcinoma unveil discrepancies in their signs and symptoms and response to treatment.…”