Glucose sensors with increased sensitivity based on composite gels containing immobilized boronic acid

Hajizadeh, Solmaz; Ivanov, Alexander E.; Jahanshahi, Mohsen; Sanati, Mohammad Hossein; Zhuravleva, N. V.; Mikhalovska, Lyubov I.; Galaev, Igor Yu.

doi:10.1016/j.reactfunctpolym.2008.09.006

Cited by 32 publications

(15 citation statements)

References 22 publications

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“… 36 , 37 The positioning of the boronic acid and the hydroxyl groups of the adsorbate are the main factors in the primary interaction. 34 In comparison to lectins and other biobased ligands, this adsorbent has a longer shelf life and is robust. In addition, phenylboronic acid can be operated under harsh conditions, e.g., at high/low pH and temperatures.…”

Section: Resultsmentioning

confidence: 99%

Synthesizing a Hybrid Nanocomposite as an Affinity Adsorbent through Surface-Initiated Atom Transfer Radical Polymerization Catalyzed by Myoglobin

Hajizadeh

Bülow

2021

ACS Omega

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A hybrid bifunctional core–shell nanostructure was synthesized for the first time via surface-initiated atom transfer radical polymerization (SI-ATRP) using myoglobin as a biocatalyst (ATRPase) in an aqueous solution. N -Isopropyl acrylamide (NIPA) and N -(3-aminopropyl)methacrylamide (APMA) were applied to graft flexible polymer brushes onto initiator-functionalized silica nanoparticles. Two different approaches were implemented to form the core–shell nanocomposite: (a) random copolymerization, Si@p(NIPA- co -APMA) and (b) sequential block copolymerization, Si@pNIPA- b -pAPMA. These nanocomposites can be used as versatile intermediates, thereby leading to different types of materials for targeted applications. In this work, a phenylboronic acid ligand was immobilized on the side chain of the grafted brushes during a series of postmodification reactions to create a boronate affinity adsorbent. The ability to selectively bind glycoproteins (ovalbumin and glycated hemoglobin) via boronic acid was assessed at two different temperatures (20 and 40 °C), where Si@pNIPA- b -APMA BA (163 mg OVA/g of particle) displayed an approximately 1.5-fold higher capacity than Si@p(NIPA- co -APMA) BA (107 mg OVA/g of particle). In addition to selective binding to glycoproteins, the nanocomposites exhibited selective binding for myoglobin due to the molecular imprinting effect during the postmodification process, that is, 72 and 111 mg Mb/g for Si@p(NIPA- co -APMA) BA and Si@pNIPA- b -pAPMA BA , respectively.

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Section: Resultsmentioning

confidence: 99%

Synthesizing a Hybrid Nanocomposite as an Affinity Adsorbent through Surface-Initiated Atom Transfer Radical Polymerization Catalyzed by Myoglobin

Hajizadeh

Bülow

2021

ACS Omega

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“…Two main applications have recently been the focus of research efforts. First, biological and biomedical applications, such as the detection of proteins and glucose [127,128], including a deep review published recently covering the applications of the sensory systems integrated in microfluidic devices [148]. The other interesting applications follows a classical research line described previously, and is focused on the detection of heavy metal ions, which is crucial for environmental and safety reasons [149].…”

Section: New Micro and Nano Sensory Devices Based On Smart Polymersmentioning

confidence: 99%

Smart Polymers in Micro and Nano Sensory Devices

et al. 2018

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The present review presents the most recent developments concerning the application of sensory polymers in the detection and quantification of different target species. We will firstly describe the main polymers that are being employed as sensory polymers, including, for example, conducting or acrylate-based polymers. In the second part of the review, we will briefly describe the different mechanisms of detection and the target species, such as metal cations and anions, explosives, and biological and biomedical substances. To conclude, we will describe the advancements in recent years concerning the fabrication of micro and nano sensory devices based on smart polymers, with a bibliographic revision of the research work published between 2005 and today, with special emphasis on research work presented since 2010. A final section exposing the perspectives and challenges of this interesting research line will end the present review article.

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“…This competitive binding strategy is frequently used to calculate the association constants of various boronic acid moieties towards a range of different potential binding agents through monitoring of the decrease in fluorescence [72,73,74,75,76]. The fluorescence quenching can also be employed to visually report the presence of saccharides through dissociation of the BA-ARS complex through competitive binding with the saccharide present [25,77]. …”

Section: Sensory Applicationsmentioning

confidence: 99%

Responsive Boronic Acid-Decorated (Co)polymers: From Glucose Sensors to Autonomous Drug Delivery

Vancoillie

Hoogenboom

2016

Sensors

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Boronic acid-containing (co)polymers have fascinated researchers for decades, garnering attention for their unique responsiveness toward 1,2- and 1,3-diols, including saccharides and nucleotides. The applications of materials that exert this property are manifold including sensing, but also self-regulated drug delivery systems through responsive membranes or micelles. In this review, some of the main applications of boronic acid containing (co)polymers are discussed focusing on the role of the boronic acid group in the response mechanism. We hope that this summary, which highlights the importance and potential of boronic acid-decorated polymeric materials, will inspire further research within this interesting field of responsive polymers and polymeric materials.

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Glucose sensors with increased sensitivity based on composite gels containing immobilized boronic acid

Cited by 32 publications

References 22 publications

Synthesizing a Hybrid Nanocomposite as an Affinity Adsorbent through Surface-Initiated Atom Transfer Radical Polymerization Catalyzed by Myoglobin

Synthesizing a Hybrid Nanocomposite as an Affinity Adsorbent through Surface-Initiated Atom Transfer Radical Polymerization Catalyzed by Myoglobin

Smart Polymers in Micro and Nano Sensory Devices

Responsive Boronic Acid-Decorated (Co)polymers: From Glucose Sensors to Autonomous Drug Delivery

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