Glucose‐sensitive holographic sensors

Kabilan, Satyamoorthy; Blyth, Jeff; Lee, M. C.; Marshall, Alexander J.; Hussain, Abid; Yang, Xiaoping; Lowe, Christopher R.

doi:10.1002/jmr.663

Cited by 77 publications

(63 citation statements)

References 16 publications

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“…, (3-acrylamidopropyl)trimethylammonium) with PBA derivatives. [35] Alternatively, PBA derivatives such as 2-acrylamido-5-fluorophenylboronic acid, [8] 2-(acrylamido)phenylboronate, [36] 4-vinylphenylboronic acid (4-VPBA), [37] or their copolymerized combinations [38] can be used to improve the selectivity of the hydrogel fiber sensors to glucose. Electron-withdrawing substituents may increase the sensor response by decreasing the p K a of PBA.…”

Section: Hydrogel Optical Fiber Sensorsmentioning

confidence: 99%

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

et al. 2017

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Optical fibers are widely used in biomedical applications for sensing, imaging, and therapies. Unlike existing solid-state optical fibers, soft polymer and hydrogel fibers offer physical and chemical properties well suited for functionalization with biomolecules and long-term implantation in the body. Here, hydrogel optical fibers are fabricated with glucose-sensitive moieties and the swelling-induced sensing is demonstrated. The core of the fiber is made of poly(acrylamide-co-poly(ethylene glycol) diacrylate) (p(AM-co-PEGDA)) hydrogel functionalized with phenylboronic acid. The complexation of the phenylboronic acid and cis diols of glucose molecules lowers the apparent pKa of the hydrogel network and increases the concentration of the boronate anions that enhances the Donnan osmotic pressure to swell and change the physical size of the hydrogel optical fiber. This mechanism is reversible through ester group dynamic covalent binding of the phenylboronic acid with glucose molecules. Dynamic changes in the effective RI of the hydrogel optical fiber are measured through light propagation loss. The sensor sensitivity to glucose concentration is 1.2 mmol L−1 over a physiological range of 1–12 mmol L−1. The biocompatible hydrogel optical fibers may be subcutaneously implanted for continuous monitoring of interstitial glucose concentrations.

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Section: Hydrogel Optical Fiber Sensorsmentioning

confidence: 99%

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

et al. 2017

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“…Synthesis of 3-acrylamidophenylboronic acid was conducted according to slight alterations of reported procedures (Ivanov et al, 2004;Kabilan et al, 2004). In a typical synthesis, a solution of 3-aminophenylboronic acid monohydrate (0.7 g, 4.5 mmol) in NaOH (2.8 M, 10 ml) was cooled to 0 • C, before dropwise addition of acryloylchloride (0.75 ml, 9.2 mmol) over a period of 10 min.…”

Section: Pba Synthesismentioning

confidence: 99%

“…In this context functionalized hydrogels have been examined both for glucose monitoring Kabilan et al, 2004;Miyata et al, 2004) and insulin delivery (Ende and Peppas, 1997;Traitel et al, 2000). For glucose detection mediated by hydrogels, three major strategies have been employed by incorporation of: (1) glucose-oxidase (Jung et al, 2000;Podual et al, 2000), (2) boronic acids Asher et al, 2003;Hisamitsu et al, 1997;Horgan et al, 2006;Matsumoto et al, 2003) or (3) concavalin A (Kim and Park, 2001;Miyata et al, 2004) into hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Glucose sensors based on a responsive gel incorporated as a Fabry-Perot cavity on a fiber-optic readout platform

Tierney

Volden

Stokke

2009

Biosensors and Bioelectronics

112

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“…The measurement of glucose is extremely important in the treatment of diabetes and is also of value in monitoring cell growth, since glucose is the primary carbon source in most fermentation processes [224]. Therefore, precisely engineered glucosesensitive gels have huge potential in the quest to generate self regulated modes of insulin delivery and to facilitate the construction of an artificial pancreas which would function in a manner similar to the β-cells of the pancreas.…”

Section: Glucose-sensitive Gels-mentioning

confidence: 99%

Smart polymeric gels: Redefining the limits of biomedical devices

Chaterji

Kwon

Park

2007

Progress in Polymer Science

547

363

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This review describes recent progresses in the development and applications of smart polymeric gels, especially in the context of biomedical devices. The review has been organized into three separate sections: defining the basis of smart properties in polymeric gels; describing representative stimuli to which these gels respond; and illustrating a sample application area, namely, microfluidics. One of the major limitations in the use of hydrogels in stimuli-responsive applications is the diffusion rate limited transduction of signals. This can be obviated by engineering interconnected pores in the polymer structure to form capillary networks in the matrix and by downscaling the size of hydrogels to significantly decrease diffusion paths. Reducing the lag time in the induction of smart responses can be highly useful in biomedical devices, such as sensors and actuators. This review also describes molecular imprinting techniques to fabricate hydrogels for specific molecular recognition of target analytes. Additionally, it describes the significant advances in bottom-up nanofabrication strategies, involving supramolecular chemistry. Learning to assemble supramolecular structures from nature has led to the rapid prototyping of functional supramolecular devices. In essence, the barriers in the current performance potential of biomedical devices can be lowered or removed by the rapid convergence of interdisciplinary technologies.

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Glucose‐sensitive holographic sensors

Cited by 77 publications

References 16 publications

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

Glucose sensors based on a responsive gel incorporated as a Fabry-Perot cavity on a fiber-optic readout platform

Smart polymeric gels: Redefining the limits of biomedical devices

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