Glucose sensors based on a responsive gel incorporated as a Fabry-Perot cavity on a fiber-optic readout platform

Tierney, Sven; Volden, Sondre; Stokke, Bjørn Torger

doi:10.1016/j.bios.2008.10.014

Cited by 91 publications

(120 citation statements)

References 28 publications

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“…Binding can be observed by fluorescence change or by changes in swelling state of a hydrogel in which PBA moieties is incorporated. Several devices have been proposed based on the swelling/shrinking effect, including hydrogels containing colloidal crystal arrays that change color upon swelling and shrinking due to changes in Bragg spacing [7][8][9][10][11], holograms incorporated into hydrogels that also change color [12,13], hydrogel-coated tips of optical fibers that operate as Fabry-Perot interferometers [14,15], and confined, nearly isochoric hydrogels that exert swelling pressure on microfabricated confining structures, with pressure detected either piezoresistively [16][17][18] or electromagnetically [19,20]. Figure 1 shows the simplest mechanism by which PBA responds to sugar molecules [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Swelling Properties of Hydrogels Containing Phenylboronic Acids

2013

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Phenylboronic acids are a class of compounds that bind glucose and other sugars. When polymerized into hydrogels, they provide a convenient nonenzymatic means for sensing glucose concentration, provided competing sugars are present at negligible concentrations. In this paper we provide a comprehensive study of swelling of hydrogels containing methacrylamidophenylboronic acid (MPBA), as a function of pH and concentration of either glucose or fructose. In one set of hydrogels, MPBA is substituted at 20 mol· % in a polyacrylamide hydrogel [p(MPBA-co-AAm)], while in a second set of hydrogels, 20 mol· % MPBA is supplemented with 20 mol· % of N-3-(dimethylaminopropyl methacrylamide) [p(MPBA-co-DMP-co-AAm)]. Swelling curves are markedly different for fructose and glucose, and for the two sets of hydrogels. While fructose alters swelling by binding and contributing to the ionization of MPBA, glucose does the same, but it also can form crosslinking bridges between separate chains, leading to hydrogel shrinkage. While the [p(MPBA-co-AAm)] hydrogels behaved as polyacids, swelling monotonically with increasing pH, the [p(MPBA-co-DMP-co-AAm)] hydrogels exhibited polyampholyte behavior, with swelling minima at intermediate pH values.

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Section: Introductionmentioning

confidence: 99%

Swelling Properties of Hydrogels Containing Phenylboronic Acids

2013

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“…Nevertheless, differences in swelling can in turn cause changes in the optical or electrical properties of the hydrogel, enabling various means of detection with significantly improved accuracy. Tierney et al 28 developed an optical sensor for glucose detection using PBA incorporated in a hydrogel as a Fabry--Perot cavity at the end of an optical fiber. The optical length of the gel can be determined through an interface wave formed by reflection from light in fiber--gel and gel--solution interfaces.…”

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confidence: 99%

Impedance spectroscopy for monosaccharides detection using responsive hydrogel modified paper-based electrodes

Daikuzono

Delaney

Tesfay

et al. 2017

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Herein we present a novel sensor for the detection of monosaccharides (e.g. glucose, fructose) in solution, using electrical impedance spectroscopy. The sensor is based on carbon interdigitated electrodes, printed on paper using screen printing. The surface of the electrodes was modified with a thin layer of hydrogel containing acrylamide copolymerised with 20 mol% 3--(Acrylamido)phenylboronic acid (PBA). It was observed that the hydrogel layers containing 20 mol% PBA swell considerably in the presence of glucose and fructose. This in turn changes the measured impedance across the electrodes, making it a suitable sensor for the quantitative detection of saccharides. We investigated the impedance and capacitance variations with different concentrations of glucose and fructose (0 - 5 mM) in aqueous phosphate buffer solutions. Variations in impedance were attributed to changes in the dielectric properties of the hydrogel under an applied electric field, due to swelling of the hydrogel layer induced by uptake and binding of sugar molecules to the boronate species within the gel. Impedance measurements at 1 kHz demonstrated that hydrogel swelling leads to an increased mobility of ions within the swollen hydrogel layer. The impedance decreased with increasing sugar concentration and the relative capacitance curves are markedly different for fructose and glucose, as the hydrogel exhibits greater swelling in the presence of fructose than glucose over the same concentration range. As the proposed sensor was shown to be suitable for the detection of glucose at concentration levels found in human sweat, future work will focus on the incorporation of these modified paper--based electrodes into wearable skin patches for non--invasive sugar monitoring in sweat.

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“…The three solutions were mixed together yielding 10 wt% of AAM, 0.22, 0.44 and 0.88 mol% AMPSA relative to AAM, 3, 6 or 12 mol% Bis relative to AAM, and 0.15 mol% of initiator relative to AAM in the pregel solutions. Aliquots of the pre-gel solutions were deposited on the tip of the functionalized fiber and polymerized as described [1][2][3][4]45].…”

Section: Anionic Hydrogelsmentioning

confidence: 99%

“…It has already proved its potential in sensing such analytes as glucose [2,3] and oligonucleotides [4][5][6]. Herein we present the technique as a useful tool for label-free monitoring of swelling phenomena occurring in various hydrogelamphiphile and hydrogel-amphiphile-macrocycle cases.…”

Section: Introductionmentioning

confidence: 99%

High resolution interferometry as a tool for characterization of swelling of weakly charged hydrogels subjected to amphiphile and cyclodextrin exposure

Gao

Gawel

Stokke

2013

Journal of Colloid and Interface Science

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A high resolution interferometric technique was used to determine swelling behavior of weakly charged polyacrylamide hydrogels in the presence of oppositely charged surfactants and subsequent exposure to cyclodextrins. Hydrogels of copolymerized acrylamide and 2-acrylamido-2-methyl-1-propanesulfonic acid (0.22, 0.44, 0.88 mol%) and crosslinked with bisacrylamide (3, 6, 12 mol%) were employed. The equilibrium swelling and swelling kinetics of the hydrogels were determined with 2 nanometer resolution of the optical length and sampled at approximately 1 Hz. These properties were determined for the hydrogels exposed to cationic surfactants dodecyltrimethylammonium bromide (DTAB) and cetyltrimethylammonium bromide (CTAB) at concentrations from 10

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Glucose sensors based on a responsive gel incorporated as a Fabry-Perot cavity on a fiber-optic readout platform

Cited by 91 publications

References 28 publications

Swelling Properties of Hydrogels Containing Phenylboronic Acids

Swelling Properties of Hydrogels Containing Phenylboronic Acids

Impedance spectroscopy for monosaccharides detection using responsive hydrogel modified paper-based electrodes

High resolution interferometry as a tool for characterization of swelling of weakly charged hydrogels subjected to amphiphile and cyclodextrin exposure

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