Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy

Liu, Junyu; Liu, Haifeng; Jia, Yongliang; Tan, Ziwei; Hou, Ruxia; Lu, Jie; Luo, Dongmei; Fu, Xinyu; Wang, Lu; Wang, Xiangyu

doi:10.1080/09205063.2022.2068948

Cited by 15 publications

(8 citation statements)

References 71 publications

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“…After S. aureus and E. coli colonized the hydrogel, TA caused bacterial deformation and membrane fusion, thus killing bacteria. Moreover, the antibacterial effects of TA against other bacteria, such as P. aeruginosa , Streptococcus pyogenes , and Pseudomonas aeruginosa , − have also been reported, which suggests that TA-enhanced GN hydrogels may exhibit broad-spectrum antibacterial effects.…”

Section: Resultsmentioning

confidence: 98%

Low-Swelling Adhesive Hydrogel with Rapid Hemostasis and Potent Anti-Inflammatory Capability for Full-Thickness Oral Mucosal Defect Repair

Zhu

Xie

et al. 2022

ACS Appl. Mater. Interfaces

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Full-thickness oral mucosal defects are accompanied by significant blood loss and frequent infections. Instead of conventional therapies that separate hemostasis and anti-inflammation in steps, emerging hydrogels can integrate multiple functions for the successive process after defect including hemostasis/inflammatory phase, proliferative phase, and remodeling phase. However, these functions can be easily compromised by rapid swelling and degradation of hydrogels in wet oral environment. Herein, a low-swelling adhesive hydrogel with rapid hemostasis and potent anti-inflammatory capability was developed using a dual cross-linking strategy as well as a safe and facile fabrication method. It was double cross-linked hydrogel consisting of gelatin methacrylate (GelMA), nanoclay, and tannic acid (TA) (referred to as GNT). GNT hydrogel exhibited low-swelling (one-eighth of that of GelMA), excellent stretchability (211.86%), and good adhesive properties (5 times the adhesive strength of GelMA). Physicochemical characterization illuminated the close interactions among the three components. A systematic investigation of the therapeutic effects of GNT hydrogels was performed. In vitro and in vivo experimental results demonstrated the potent hemostatic property and excellent antibacterial and anti-inflammatory effects of GNT hydrogels. The RNA sequencing analysis results for rat full-thickness oral mucosal samples showed that GNT reduced inflammation levels by down-regulating the expression of multiple inflammation-related pathways, including TNF and IL-17 pathways. It also enhanced the expression levels of tissue regeneration-related genes and thus accelerated defective mucosal repair. More importantly, the therapeutic effects of GNT were superior to those of a commercial oral tissue repair membrane when applied for full-thickness oral mucosal defect repair in rabbits. In summary, the prepared low-swelling adhesive GNT hydrogel with rapid hemostasis and potent anti-inflammatory is a promising therapy for full-thickness mucosal defect in the moist and dynamic oral environment.

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Section: Resultsmentioning

confidence: 98%

Low-Swelling Adhesive Hydrogel with Rapid Hemostasis and Potent Anti-Inflammatory Capability for Full-Thickness Oral Mucosal Defect Repair

Zhu

Xie

et al. 2022

ACS Appl. Mater. Interfaces

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“…The hydrogels release controlled doses of metronidazole as antimicrobial therapy against P. gingivalis [ 310 , 311 ]. A different approach used a glucose-sensitive antibacterial and anti-inflammatory chitosan hydrogel film with controlled release of tannic acid [ 312 ]. The addition of tannic acid increased the mechanical properties of the film and demonstrated adequate biocompatibility with inhibition of nitrite, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) for anti-inflammatory application.…”

Section: Smart Dental Materials For Antimicrobial and Antibiofilm The...mentioning

confidence: 99%

Smart dental materials for antimicrobial applications

Montoya

Roldán

et al. 2023

Bioactive Materials

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“…Firstly, some researchers have emphasized the control of tissue inflammation and immunomodulation, potentially neglecting the fact that the ultimate aim of periodontal therapy is to promote the regeneration of periodontal tissue. [17][18][19] Secondly, traditional hydrogels often exhibit suboptimal biomechanical properties, making them susceptible to damage from external forces when applied to periodontal tissue. 20,21 In recent years, incorporating nanosized particles or other bioactive materials, as well as increasing the hydrogel polymer concentration or crosslink density, have been commonly employed as major strategies to enhance mechanical property.…”

Section: Introductionmentioning

confidence: 99%

A whole-course-repair system based on ROS/glucose stimuli-responsive EGCG release and tunable mechanical property for efficient treatment of chronic periodontitis in diabetic rats

Feng,

Zhang,

Zhang

et al. 2024

J. Mater. Chem. B

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Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy

Cited by 15 publications

References 71 publications

Low-Swelling Adhesive Hydrogel with Rapid Hemostasis and Potent Anti-Inflammatory Capability for Full-Thickness Oral Mucosal Defect Repair

Low-Swelling Adhesive Hydrogel with Rapid Hemostasis and Potent Anti-Inflammatory Capability for Full-Thickness Oral Mucosal Defect Repair

Smart dental materials for antimicrobial applications

A whole-course-repair system based on ROS/glucose stimuli-responsive EGCG release and tunable mechanical property for efficient treatment of chronic periodontitis in diabetic rats

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