Glucose-sensitive colorimetric sensor based on peroxidase mimics activity of porphyrin-Fe3O4 nanocomposites

Liu, Qingyun; Li, Hui; Zhao, Qing‐Ru; Zhu, Renren; Yang, Yanting; Jia, Qingyan; Bian, Bing; Zhuo, Linhai

doi:10.1016/j.msec.2014.04.038

Cited by 84 publications

(39 citation statements)

References 51 publications

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“…From analysis of dose‐response curves, the limit of detection (LOD) for glucose was determined to be as low as 2.5 × 10 −6 m with a linear range of 5 × 10 −6 –150 × 10 −6 m (Figure c). Although the previous reports using GOx/HRP bienzyme system showed a lower detection limit down to 0.3 × 10 −6 m , the LOD and linear range values of our system are comparable to the best of recent reports describing nanostructures‐based measurements of glucose (Table S2, Supporting Information) . The proposed system also shows excellent selectivity toward the corresponding target glucose, while no significant fluorescence was generated by negative control sugars such as lactose, sucrose, maltose, arabinose, and fructose, even at tenfold higher concentrations (Figure d).…”

Section: Resultssupporting

confidence: 81%

Magnetic Nanoparticles‐Embedded Enzyme‐Inorganic Hybrid Nanoflowers with Enhanced Peroxidase‐Like Activity and Substrate Channeling for Glucose Biosensing

Cheon

Adhikari

Chung

et al. 2019

Adv Healthcare Materials

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It is reported that glucose oxidase (GOx)‐copper hybrid nanoflowers embedded with Fe3O4 magnetic nanoparticles (MNPs) exhibit superior peroxidase‐mimicking activity as well as substrate channeling for glucose detection. This is due to the synergistic integration of GOx, crystalline copper phosphates and MNPs being in close proximity within the nanoflowers. The preparation of MNP‐embedded GOx‐copper hybrid nanoflowers (MNPs‐GOx NFs) begins with the facile conjugation of amine‐functionalized MNPs with GOx molecules via electrostatic attraction, followed by the addition of copper sulfate that leads to full blooming of the hybrid nanoflowers. In the presence of glucose, the catalytic action of GOx entrapped in the nanoflowers generates H2O2, which is subsequently used by peroxidase‐mimicking MNPs and copper phosphate crystals, located close to GOx molecules, to convert Amplex UltraRed substrate into a highly fluorescent product. Using this strategy, the target glucose is successfully determined with excellent selectivity, stability, and magnetic reusability. This biosensor based on hybrid nanoflowers also exhibits a high degree of precision and reproducibility when applied to real human blood samples. Such novel MNP‐embedded enzyme‐inorganic hybrid nanoflowers have a great potential to be expanded to any oxidases, which will be highly beneficial for the detection of various other clinically important target molecules.

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Section: Resultssupporting

confidence: 81%

Magnetic Nanoparticles‐Embedded Enzyme‐Inorganic Hybrid Nanoflowers with Enhanced Peroxidase‐Like Activity and Substrate Channeling for Glucose Biosensing

Cheon

Adhikari

Chung

et al. 2019

Adv Healthcare Materials

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“…In order to improve colloidal stability, high affinity toward the substrates, and catalytic activities of MNPs, a suitable surface modification and metal doping was also studied by many groups . We discuss this in detail in Section .…”

Section: Peroxidase‐like Activity Of Nanomaterialsmentioning

confidence: 99%

“…This method was low‐cost and simple, and showed highly selective and sensitive for glucose detection with a LOD of 1.0 × 10 −6 mol L −1 over a linear range from 3.0 × 10 −6 mol L −1 to 1.0 × 10 −3 mol L −1 . Other materials such as ATP and porphyrin were also used to modify Fe 3 O 4 MNPs to enhance the peroxidase catalytic activities and improve the detection limit and sensitivity in glucose detection (see Table 1 ).…”

Section: Glucose Biosensormentioning

confidence: 99%

Peroxidase‐Like Activity of Smart Nanomaterials and Their Advanced Application in Colorimetric Glucose Biosensors

Liu

Huang

Qin

et al. 2019

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Diabetes is a dominating health issue with 425 million people suffering from the disease worldwide and 4 million deaths each year. To avoid further complications, the diabetic patient blood glucose level should be strictly monitored despite there being no cure for diabetes. Colorimetric biosensing has attracted significant attention because of its low cost, simplicity, and practicality. Recently, some nanomaterials have been found that possess unexpected peroxidase‐like activity, and great advances have been made in fabricating colorimetric glucose biosensors based on the peroxidase‐like activity of these nanomaterials using glucose oxidase. Compared with natural horseradish peroxidase, the nanomaterials exhibit flexibility in structure design and composition, and have easy separation and storage, high stability, simple preparation, and tunable catalytic activity. To highlight the significant progress in the field of nanomaterial‐based peroxidase‐like activity, this work discusses the various smart nanomaterials that mimic horseradish peroxidase and its mechanism and development history, and the applications in colorimetric glucose biosensors. Different approaches for tunable peroxidase‐like activity of nanomaterials are summarized, such as size, morphology, and shape; surface modification and coating; and metal doping and alloy. Finally, the conclusion and challenges facing peroxidase‐like activity of nanomaterials and future directions are discussed.

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“…31 Liu and coworkers have studied functional organic molecules modified magnetic nanoparticles which demonstrated the enhanced peroxidase mimetic activity. [32][33][34] The previous studies prove that people have paid attention to the nanocomposites based on magnetic materials as peroxidase mimics.…”

Section: Introductionmentioning

confidence: 99%

Corrole functionalized iron oxide nanocomposites as enhanced peroxidase mimic and their application in H2O2 and glucose colorimetric sensing

Gao¹,

Zhang²,

Lyu³

et al. 2018

Eng. Sci.

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For the first time, functional Corrole molecules modified iron oxide (Fe 3 O 4) magnetic nanoparticles (MNPs) were prepared by a facile two-step method. The Corrole-Fe 3 O 4 nanocomposites exhibited a higher peroxidase-like activity than that of pure Fe 3 O 4 nanoparticles, and accelerated the oxidation of peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) with the help of hydrogen peroxide (H 2 O 2) only in 5 min, attributing to hydroxyl radicals (•OH) generated in the process of oxidation of TMB. Kinetic analysis showed that the catalytic behaviors followed the typical Michaelis-Menten kinetics. Additionally, Corrole-Fe 3 O 4 exhibits several advantages including low cost, easy separation, facile fabrication, and high catalytic efficiency. Based on the catalytic activity of Corrole-Fe 3 O 4 nanocomposites, a simple, sensitive, and selective colorimetric biosensor for H 2 O 2 and glucose determination was successfully designed. The linear relationships of absorbance of oxidized TMB at 652 nm with H 2 O 2 or glucose concentration were obtained from 10 μM to 100 μM with a detection limit of 3.6 μM and 4 μM to 40 μM with the detection limit as low as 2.46 μM, respectively. The results demonstrate that the Corrole-Fe 3 O 4 nanocomposites have potential applications in bioanalysis and biodetection.

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Glucose-sensitive colorimetric sensor based on peroxidase mimics activity of porphyrin-Fe3O4 nanocomposites

Cited by 84 publications

References 51 publications

Magnetic Nanoparticles‐Embedded Enzyme‐Inorganic Hybrid Nanoflowers with Enhanced Peroxidase‐Like Activity and Substrate Channeling for Glucose Biosensing

Magnetic Nanoparticles‐Embedded Enzyme‐Inorganic Hybrid Nanoflowers with Enhanced Peroxidase‐Like Activity and Substrate Channeling for Glucose Biosensing

Peroxidase‐Like Activity of Smart Nanomaterials and Their Advanced Application in Colorimetric Glucose Biosensors

Corrole functionalized iron oxide nanocomposites as enhanced peroxidase mimic and their application in H2O2 and glucose colorimetric sensing

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