Glucose-lowering Potential of Cocoa Powder Intake - An Avenue for Positive Management of Diabetes Mellitus

Olasope, T; Fadupin, Grace T.; Olubamiwa, O.; Jayeola, C

doi:10.9734/bjmmr/2016/24534

Cited by 6 publications

(11 citation statements)

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“…The result of this study agree with those of Olasope et al (2016) , which reported that fasting blood glucose levels of alloxan-induced diabetic rats significantly decreased upon administration of cocoa powder. In addition, plantain root and stem juices have been reported to lower blood glucose levels ( Omobuwajo et al, 2011 ).…”

Section: Resultssupporting

confidence: 92%

“…Several studies have reported nutraceutical potential of cocoa powder extracts for modulating/controlling blood glucose levels and promoting antioxidant enzymes ( Amin et al, 2004 ; Tomaru et al, 2007 ; Jalil et al, 2008 ). Indeed, a recent study corroborated the veracity of cocoa powder in the management of DM ( Olasope et al, 2016 ).…”

Section: Introductionmentioning

confidence: 75%

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Effect of Plantain Bulb’s Extract-Beverage Blend on Blood Glucose Levels, Antioxidant Status, and Carbohydrate Hydrolysing Enzymes in Streptozotocin-Induced Diabetic Rats

Olagunju¹,

Oluwajuyitan²,

Oyeleye³

2020

pnf

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 75%

Effect of Plantain Bulb’s Extract-Beverage Blend on Blood Glucose Levels, Antioxidant Status, and Carbohydrate Hydrolysing Enzymes in Streptozotocin-Induced Diabetic Rats

Olagunju¹,

Oluwajuyitan²,

Oyeleye³

2020

pnf

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“…7 Penelitian Marco et al (2014) menunjukan bahwa pemberian bubuk cokelat mampu menormalkan berat badan mencit diabetes melitus 8 . Selanjutnya penelitian eksperimental yang dilakukan oleh Olasope et al (2016) menunjukan bahwa bubuk cokelat mampu berperan sebagai agen anti diabetes dengan percobaan pada tikus diabetes melitus selama tiga minggu. Hasil penelitiannya menunjukan bahwa bubuk kakao dapat meningkatkan berat badan serta dapat menurunkan kadar gukosa darah tikus diabetes melitus yang diinduksi aloksan.…”

Section: Pendahuluanunclassified

Pengaruh Pemberian Minuman Cokelat (Theobroma cacao L.) Terhadap Berat Basah Organ Hati Tikus Diabetes Melitus

Ratri

Yulianti²,

Restuti

2021

arteri

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Cacao (Theobroma cacao L.) is known to have enormous potential advantages because they contain vitamins A1, B1, B2, C, D, and E as well as minerals such as iron, zinc, phosphorus, magnesium, and copper. In addition, chocolate is also known to be rich in active antioxidant ingredients such as phenolic compounds, prociandin, and flavonoids which can reduce the bad effects of antioxidants in the body. giving chocolate to experimental animals and consumption interventions in humans can prevent and overcome the problem of several diseases, one of which is diabetes mellitus. The purpose of this study was to see the effect of giving cocoa powder drink to the wet weight of the liver in rats with diabetes mellitus. The research design used was experimental research using a completely randomized design with a post-test only control group design. The experimental sample used fifteen male white rats (Rattus norvegicus) Sprague Dawley strain. The experimental mice were divided into 5 groups, namely the negative control group (K-), namely normal rats without any treatment, the positive group, namely the diabetes mellitus (K +) group; treatment group 1 (KP1), treatment group 2 (KP2), treatment group 3 (KP3), namely the diabetes mellitus group of rats that were given the treatment of chocolate drink with a concentration of cocoa powder drink doses of 2%, 4% and 6%. Data analysis was performed using the One Way ANOVA test. Results: The results showed that the organ weight in the group K- = 10.46 ± 0.44; K + = 11.49 ± 0.39; KP1 = 9.95 ± 0.60; KP2 = 11.30 ± 0.60; KP3 = 11.09± 0.90. Statistical analysis showed that there was no significant difference for each treatment with a value of p = 0.077. The conclusions in the study regarding the effect of giving chocolate drink on the wet weight of the liver in rats with diabetes mellitus showed that giving cocoa powder with a concentration of 2%, 4% and 6% was not able to significantly affect the wet weight of the liver.

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“…Penelitian Ruzaidi (2008) tentang efek hipoglikemik dari ekstrak polifenol kakao malaysia pada tikus DM menunjukkan penurunan kadar glukosa darah dan peningkatan aktivitas insulin tikus. Penelitian pada tikus yang diinduksi aloksan monohidrat kemudian di beri perlakuan dengan bubuk kakao 1 -4 % menunjukkan bahwa bubuk kakao 4% (0,8gr/ekor/hari) dapat menormalkan kadar glukosa darah puasa dibandingkan dengan tikus DM (Olasope et al, 2016). Penelitian selanjutnya tentang pengaruh bubuk kakao terhadap parameter hematologi dan efek anti diabetik menunjukkan hasil bahwa pemberian bubuk kakao sebanyak 2% (0,4gr/ekor/hari) mampu meningkatkan aktitivas antidiabetik pada glukosa darah (Olasope et al, 2017).…”

Section: Pendahuluanunclassified

“…Jurnal Riset Kesehatan, 7 (2), 2018, 60 -60 dapat menormalkan kadar glukosa darah puasa pada tikus DM (Olasope et al, 2016).…”

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Intervensi Bubuk Kakao Terhadap Perubahan Kadar Gula Darah Puasa Tikus Sprangue Dawley Diabetes Melitus

Restuti

Yulianti

Nuraini

2018

Jurnal Riset Kesehatan

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AbstrakBubuk kakao mempunyai kemampuan paling tinggi dalam menghentikan kerusakan organ tubuh akibat radikal bebas. Kandungan antioksidan yang ada didalam bubuk kakao diduga dapat menghentikan kerusakan sel beta pankreas karena radikal bebas sehingga dapat meningkatkan sekresi insulin pada DM. Tujuan penelitian untuk menguji efek bubuk kakao Indonesia terhadap perubahan kadar gula darah puasa tikus Sprangue dawley diabetes melitus. Desain penelitian pre-post test control group design. Populasi penelitian yaitu tikus putih jantan galur Sprague -Dawley. Ada 3 kelompok perlakuan dalam penelitian ini. Kelompok kontrol negatif diberi pakan standar (Rat Bio), sedangkan kelompok kontrol positif dan perlakuan diberi pakan High Fat Diet selama 6 minggu. Pada akhir minggu ke 6 kelompok kontrol positif dan perlakuan diinduksi streptozotocin (STZ) low dose 30 mg/Kg BB ip. Tiga hari post STZ tikus dicek kadar gula darah puasa menggunakan metode GOD-PAP. Kelompok perlakuan disonde larutan bubuk kakao 0,4gr/ekor/hari selama 2 minggu, kemudian di cek kadar gula darah puasa. Hasil uji one way ANOVA kadar gula darah puasa pretest p 0,036, sedangkan postest p 0,007 yang berarti terdapat perbedaan signifikan antar ke 3 kelompok perlakuan. Dapat disimpulkan bahwa pemberian bubuk kakao 0,4 gram/ekor/hari dapat menurunkan kadar gula darah puasa tikus Sprangue Dawley diabetes melitus. Kata kunci: bubuk kakao; diabetes melitus; kadar gula darah puasa Abstract [INTERVENTION OF COCOA POWDER ON CHANGES IN FAST FLOOD SUGAR CONTENTS SPRAGUE DAWLEY RATS DIABETES MELLITUS]Cocoa powder has the highest ability to stop organ damage due to free radicals. The content of antioxidants in cocoa powder is thought to stop pancreatic beta cell damage due to free radicals so that it can increase insulin secretion in DM. The objective of research is to examine the effect of Indonesian cocoa powder on changes in fasting blood sugar levels of Sprangue dawley rats with diabetes mellitus. Research design pre-post test control group design. The study population was Sprague-Dawley male white rats. There were 3 treatment groups in this study. The negative control group was given standard feed (Rat Bio), while the positive control group and treatment were given High Fat Diet for 6 weeks. At the end of the 6th week the positive control group and 30 mg / Kg BB ip streptozotocin (STZ) low dose treatment were induced. Three days after the STZ post, rats were tested for fasting blood sugar levels using the GOD-PAP method. The treatment group disonde 0.4g / head / day cocoa powder solution for 2 weeks, then check fasting blood sugar levels. The results of the one way ANOVA test for pretest fasting blood sugar level p 0.036, while posttest p 0.007 means that there are significant differences between the 3 treatment groups. It can be concluded that administration of cocoa powder 0.4 grams / head / day can reduce fasting blood sugar levels in Sprangue Dawley rats with diabetes mellitus

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Glucose-lowering Potential of Cocoa Powder Intake - An Avenue for Positive Management of Diabetes Mellitus

Cited by 6 publications

References 0 publications

Effect of Plantain Bulb’s Extract-Beverage Blend on Blood Glucose Levels, Antioxidant Status, and Carbohydrate Hydrolysing Enzymes in Streptozotocin-Induced Diabetic Rats

Effect of Plantain Bulb’s Extract-Beverage Blend on Blood Glucose Levels, Antioxidant Status, and Carbohydrate Hydrolysing Enzymes in Streptozotocin-Induced Diabetic Rats

Pengaruh Pemberian Minuman Cokelat (Theobroma cacao L.) Terhadap Berat Basah Organ Hati Tikus Diabetes Melitus

Intervensi Bubuk Kakao Terhadap Perubahan Kadar Gula Darah Puasa Tikus Sprangue Dawley Diabetes Melitus

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