Glucose initially inhibits and later stimulates blood ROS generation

Stief, T.

doi:10.4236/jdm.2013.31003

Cited by 4 publications

(3 citation statements)

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“…Refined cereal products have a high glycaemic index, thus leading to high serum glucose concentration [ 36 ]. According to literature data [ 37 ], abnormal serum glucose concentration may influence ROS formation via generation of NADPH, which directly explains the correlation between high frequency of refined cereal product consumption and low TAC. Moreover, lung cancer patients often suffer from carbohydrate metabolism disorders, high insulin concentration, and elevated insulin resistance [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Total antioxidant status in lung cancer is associated with levels of endogenous antioxidants and disease stage rather than lifestyle factors – preliminary study

Zabłocka‐Słowińska¹,

Porębska²,

Gołecki³

et al. 2016

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Aim of the studyDecreased total antioxidant capacity (TAC) has been reported in different neoplasms, including lung cancer. However, no study concerning the relationship between endogenous antioxidants, lifestyle factors, and TAC has been conducted among lung cancer patients. The purpose of the study was to investigate the associations between endogenous antioxidants, severity of disease, lifestyle factors, and TAC in lung cancer patients.Material and methodsThe study was conducted among 59 lung cancer patients. The levels of total antioxidant status (ATBS method), endogenous antioxidants, and C-reactive protein were measured in patients’ sera automatically. Dietary habits of the subjects were evaluated based on the Food Frequency Questionnaire (FFQ) on the day of admission to hospital.ResultsWe found a positive correlation between serum albumin, uric acid (UA), and TAC and a negative correlation between CRP and TAC. Moreover, TAC was significantly positively associated with disease stage. We did not find any significant relationship between the frequency of selected food consumption and TAC in lung cancer patients, except for a positive correlation between the frequency of refined cereal products consumption and TAC level. Smoking status did not correlate with TAC.ConclusionsTotal antioxidant status of lung cancer patients results from their disease stage and levels of endogenous antioxidants rather than from lifestyle factors. The lack of influence of diet and smoking on the TAC presumably result from disturbed homeostasis in which cancer, while developing, could determine the redox state to a greater extent than lifestyle factors.

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Section: Discussionmentioning

confidence: 99%

Total antioxidant status in lung cancer is associated with levels of endogenous antioxidants and disease stage rather than lifestyle factors – preliminary study

Zabłocka‐Słowińska¹,

Porębska²,

Gołecki³

et al. 2016

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show abstract

“…The storage time and temperature before the test could be done becomes a confounding factor that may influence the test results. Unfortunately, all the studies mentioned above [3][4][5][6][7] did not clearly mention how the samples were kept before the measurement of ROS was done. We therefore conducted this study to clarify the effect of storage time and temperature on the generation of ROS in the peripheral blood cells.…”

mentioning

confidence: 98%

“…Imbalance between ROS generation and redox counteraction has been implicated in many pathological conditions, such as cardiovascular disease, cancer, diabetes mellitus, rheumatoid arthritis, Alzheimer's disease, Parkinson's disease, ischemia/reperfusion injury, and aging [2]. Therefore, many studies now measuring ROS level in the blood/blood cells to see the correlation between ROS and various disease status [3][4][5][6], as well as response to external stimuli, including mobile phone radiation [7]. The measurement of blood ROS and vast majority of laboratory tests is better to be conducted immediately after the blood drawing.…”

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confidence: 99%