Glucose Challenge Stimulates Reactive Oxygen Species (ROS) Generation by Leucocytes

Mohanty, Priya; Hamouda, Wael; Garg, Rajesh; Aljada, Ahmad; Ghanim, Husam; Dandona, Paresh

doi:10.1210/jcem.85.8.6854

Cited by 459 publications

(127 citation statements)

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“…This strong relation between blood glucose level and CAD made clinicians and researchers associate hyperglycemia and insulin resistance states to circulatory cell dysfunction. A study done by Mohanty et al revealed an increase in ROS by leukocytes after 75grams glucose challenge [142]. This was also confirmed by Dandona et al after giving 30 grams of glucose in his study [143].…”

Section: Insulin and Insulin Sensitizerssupporting

confidence: 60%

Inflammation in Atherosclerosis: A New Therapeutic Target

Skouri

Zalloua²,

Abchee

2005

CMCAIAA

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Coronary artery disease (CAD) is still the leading cause of death in men and women, despite our better understanding of the disease process. Atherosclerosis, the underlying pathological process that leads to CAD, was considered a disorder of lipid metabolism and deposition of lipid material in the vessel wall. Today however, it is viewed as an inflammatory disease and it is evident that inflammation is involved in every step of plaque formation, progression and rupture. At the cellular level, recent studies on human and animal models illustrated the involvement of nuclear transcription factors in early lesion formation and lesion progression. Nuclear factor Kappa-B (NF-κB) activation can result in a proinflammatory, atherogenic process while peroxisome proliferator-activated receptors (PPARs) and their ligands have an atheroprotective, anti-inflammatory effect. Many drugs and compounds have been shown to block NF-κB or reduce its effects while others activate PPARs and slow or halt the inflammatory process. In this review, we will discuss the contribution of NF-κB and PPARs to the different inflammatory pathways that contribute to atherosclerosis. We will also discuss the effect on the inflammatory pathways by different therapeutic options like the angiotensin converting enzyme (ACE) inhibitors and the angiotensin receptor blockers (ARBs), insulin and insulin sensitizers, statins and fibrates, aspirin and salicylates, and antibacterial and antiviral therapy.

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Section: Insulin and Insulin Sensitizerssupporting

confidence: 60%

Inflammation in Atherosclerosis: A New Therapeutic Target

Skouri

Zalloua²,

Abchee

2005

CMCAIAA

View full text Add to dashboard Cite

show abstract

“…We evaluated TOS and TAS levels at 5th hour after performing OGTT and MMT. Given that ROS generations were demonstrated to increase at around 1st and 2nd hours, and progressively to decrease in other studies [22,26], our drawing blood samples at 5th hour to evaluate TAS and TOS levels may be a mistaken effort.…”

Section: Pcos Polycystic Ovary Syndrome Tos Total Oxidant Status Tamentioning

confidence: 93%

“…Ceriello et al showed for the first time that TAS levels decrease after OGTT and MMT in normal individuals and patients with type 2 DM [40,41]. Additionally, Mohanty et al [26]. reported that after loading 14 patients 75 gr of glucose, the production of reactive oxygen species (ROS) increases p47 phox (an integral protein component of NADPH oxidase) and thiobarbituric acid reactive substances (TBARS), a sign of lipid peroxidation while decreasing the level of alpha tocopherol.…”

Section: Pcos Polycystic Ovary Syndrome Tos Total Oxidant Status Tamentioning

confidence: 99%

“…The reduction in OS by antioxidants may display favor effects on the development of CVDs [19]. In the literature, many studies with controversial results report that macronutrients, such as carbohydrates, triglyceride and protein have a developmental effect on OS in different populations of patients [20][21][22][23][24][25][26]. Oral glucose tolerance test is frequently used in daily practice for detecting DM or gestational DM.…”

Section: Introductionmentioning

confidence: 99%

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Plasma total oxidant and antioxidant status after oral glucose tolerance and mixed meal tests in patients with polycystic ovary syndrome

Kucukaydin¹,

Duran

Başaran³

et al. 2016

J Endocrinol Invest

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“…Interestingly, macrophages from diabetic mice display a proinflammatory phenotype when compared with non-diabetic mice [40]. In addition, glucose challenge in human subjects increases ROS production and p47 phox expression in leucocytes [41]. Accordingly, analyses of the draining lymph nodes of the aortic sinus revealed increased T-cell activation in the setting of diabetes.…”

Section: Nox4-derived Ros Are Important In Diabetes-mediated T-cell Amentioning

confidence: 99%

Differential effects of NOX4 and NOX1 on immune cell-mediated inflammation in the aortic sinus of diabetic ApoE−/− mice

et al. 2016

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Oxidative stress and inflammation are central mediators of atherosclerosis particularly in the context of diabetes. The potential interactions between the major producers of vascular reactive oxygen species (ROS), NADPH oxidase (NOX) enzymes and immune-inflammatory processes remain to be fully elucidated. In the present study we investigated the roles of the NADPH oxidase subunit isoforms, NOX4 and NOX1, in immune cell activation and recruitment to the aortic sinus atherosclerotic plaque in diabetic ApoE(-/-) mice. Plaque area analysis showed that NOX4- and NOX1-derived ROS contribute to atherosclerosis in the aortic sinus following 10 weeks of diabetes. Immunohistochemical staining of the plaques revealed that NOX4-derived ROS regulate T-cell recruitment. In addition, NOX4-deficient mice showed a reduction in activated CD4(+) T-cells in the draining lymph nodes of the aortic sinus coupled with reduced pro-inflammatory gene expression in the aortic sinus. Conversely, NOX1-derived ROS appeared to play a more important role in macrophage accumulation. These findings demonstrate distinct roles for NOX4 and NOX1 in immune-inflammatory responses that drive atherosclerosis in the aortic sinus of diabetic mice.

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Glucose Challenge Stimulates Reactive Oxygen Species (ROS) Generation by Leucocytes

Cited by 459 publications

References 0 publications

Inflammation in Atherosclerosis: A New Therapeutic Target

Inflammation in Atherosclerosis: A New Therapeutic Target

Plasma total oxidant and antioxidant status after oral glucose tolerance and mixed meal tests in patients with polycystic ovary syndrome

Differential effects of NOX4 and NOX1 on immune cell-mediated inflammation in the aortic sinus of diabetic ApoE−/− mice

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