Plasma total oxidant and antioxidant status after oral glucose tolerance and mixed meal tests in patients with polycystic ovary syndrome

Kucukaydin, Zehra; Duran, Cevdet; Başaran, Mustafa; Camlica, Fatos; Erdem, Sami; Başaran, Ahmet; Kutlu, Orkide; Burnik, Ferda Sevimli; Elmas, Halis; Gonen, Mustafa Sait

doi:10.1007/s40618-016-0498-5

Cited by 11 publications

(8 citation statements)

References 46 publications

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“…One of the basic characteristics of PCOS is increased serum levels of oxidative stress markers [12]. We demonstrated in a previous study that increased oxidative stress in the body could contribute to the pathogenesis of PCOS [24].…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress has been defined as an imbalance between the formation of reactive oxygen species, which cause oxidative damage, and the antioxidant defence system [1213]. The molecular damage caused by free radicals has been asserted to lead to many diseases, such as atherosclerosis, diabetes mellitus, and PCOS [12].…”

Section: Introductionmentioning

confidence: 99%

“…The molecular damage caused by free radicals has been asserted to lead to many diseases, such as atherosclerosis, diabetes mellitus, and PCOS [12]. …”

Section: Introductionmentioning

confidence: 99%

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Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Sak

Uyanıkoğlu

Incebiyik

et al. 2018

Clin Exp Reprod Med

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ObjectiveThe aim of this study was to compare serum fetuin-A levels and oxidative stress markers, as indicators of insulin resistance, in women with polycystic ovary syndrome (PCOS) and in healthy controls.MethodsThis prospective case-control study included 46 patients with PCOS and 48 age- and body mass index–matched control women. Levels of serum hormones, fetuin-A, and oxidative stress markers were measured in blood samples taken during the early follicular period from each participant.ResultsFollicle-stimulating hormone (FSH), luteinising hormone (LH), total testosterone levels, and the LH/FSH ratio were found to be significantly higher in women with PCOS than in controls. Serum total antioxidant status, total oxidant status, and oxidative stress index parameters all indicated significantly higher levels of oxidative stress in PCOS patients than in controls. Serum fetuin-A levels, which were analyzed as an indicator of insulin resistance, were higher in the PCOS group than in the control group (210.26±65.06 µg/mL and 182.68±51.20 µg/mL, respectively; p=0.024).ConclusionThe data obtained from the present study suggest that higher levels of both serum fetuin-A and oxidative stress markers might be related with PCOS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Sak

Uyanıkoğlu

Incebiyik

et al. 2018

Clin Exp Reprod Med

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“…[32][33][34][35] Regarding ovarian pathologies, there is evidence that OS plays an important role in the excess of cellular proliferation observed in endometriosis. [36][37][38][39][40][41] Increased level of OS is associated with polycystic ovarian syndrome (PCOS) and may play a pathogenetic role in the development of insulin resistance, [42][43][44] hyperandrogenism, 43,45 and chronic inflammation observed in this disease. [46][47][48] Lipid peroxidation and endoplasmic reticulum stress induced by OS are associated with tissue injury and disruption of normal physiology in several organs including the ovary.…”

Section: Oxidative Stress and Fertilitymentioning

confidence: 99%

Oxidative Stress in Granulosa-Lutein Cells From In Vitro Fertilization Patients

et al. 2016

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Ovarian aging is associated with gradual follicular loss by atresia/apoptosis. Increased production of toxic metabolites such as reactive oxygen species (ROS) and reactive nitrogen species as well as external oxidant agents plays an important role in the process of ovarian senescence and in the pathogenesis of ovarian pathologies such as endometriosis and polycystic ovary syndrome (PCOS). This review provides a synthesis of available studies of oxidative stress (OS) in the ovary, focusing on the most recent evidence obtained in mural granulosa-lutein (GL) cells of in vitro fertilization patients. Synthesis of antioxidant enzymes such as peroxiredoxin 4, superoxide dismutase, and catalase and OS damage response proteins such as aldehyde dehydrogenase 3, member A2 decreases with aging in human GL cells, favoring an unbalance in ROS/antioxidants that mediates molecular damage and altered cellular function. The increase in OS in the granulosa cell correlates with diminished expression of follicle-stimulating hormone receptor (FSHR) and a dysregulation of the FSHR signaling pathway and may be implicated in disrupted steroidogenic function and poor response to FSH in women with aging. Women with endometriosis and PCOS have lower antioxidant production capacity that may contribute to abnormal follicular development and infertility. Further investigation of the signaling pathways involved in cellular response to OS could shed light into molecular characterization of these diseases and development of new treatment strategies to improve reproductive potential in these women.

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“…Addition of LC in the oocyte culture can improve oocyte quality, which may be related to the reduction of GCs apoptosis and improvement of mitochondrial function [19]. It is believed that the supplement of LC is bene cial to alleviate the delayed embryonic development, high DNA fragmentation and abnormal blastocyst development after long-term culture mediated by the increased ROS [20]. Therefore, treatment with LC may have the potential to improve the quality of follicles and the pregnancy outcome of IVF-ET.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of L-carnitine on the Oxidative Stress Injury of Human Ovarian Granulosa Cells

Zhang

et al. 2021

Preprint

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The protective effect of L-carnitine (LC) on the oxidative stress (OS) injury and the effect of L-carnitine on follicular stimulating hormone receptor (FSHR) of ovarian granulosa cells (GCs) were investigated. OS was induced by treatment with H2O2. We cultured KGN cells in four groups: the blank group, OS group and two L-carnitine pretreatment group (low, high). In the OS group, cell nuclear pyknosis was observed, mitochondria swelled irregularly and their cristae were fractured. Meanwhile, the cell viability, superoxide dismutase (SOD) and glutathione (GSH) contents, mitochondrial membrane potential (ΔΨm) and the level of FSHR expression were significantly decreased in the OS group. However, malonaldehyde (MDA) content, reactive oxygen species (ROS) level and apoptosis rate were significantly increased. Compared with the OS group, the morphology of cells and mitochondria in the L-carnitine pretreatment group were improved, the cell viability and the expression of FSHR was significantly increased, and the OS level was decreased. These results indicated that L-carnitine can protect the cells from OS damage induced by H2O2, enhance the antioxidant and anti-apoptotic ability of GCs, and alleviate the decrease of FSHR expression on GCs caused by OS. Therefore, L-carnitine may help prevent the ovarian aging and improve the quality of follicles.

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Plasma total oxidant and antioxidant status after oral glucose tolerance and mixed meal tests in patients with polycystic ovary syndrome

Abstract: Matsuda's ISIs derived from OGTT and MMT can be used instead of each other, and interestingly, we found a decrease in TOS levels after OGTT in patients with PCOS.

Cited by 11 publications

References 46 publications

Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Oxidative Stress in Granulosa-Lutein Cells From In Vitro Fertilization Patients

Protective Effect of L-carnitine on the Oxidative Stress Injury of Human Ovarian Granulosa Cells

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