Glucose, Blood Pressure, and Cardiovascular Risk

Lleva, Ranee R.; Inzucchi, Silvio E.

doi:10.1161/circoutcomes.112.965046

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…Whether this hyperglycaemia is severe enough to induce glucotoxicity and worsen the outcomes of the comorbidities in individuals with diabetes/ prediabetic state when Carvedilol is used needs to be analyzed. The findings of this study also highlights the need to revisit the notion that Carvedilol improves the co-morbidities in diabetics [17] by beneficial effect on blood glucose levels. Though the beneficial effects of Carvedilol when used in diabetics for various indications is not questioned [17], the notion that such a beneficial effect is due to improvement in glucose tolerance, is questioned by the findings of this study.…”

Section: Discussionmentioning

confidence: 73%

“…(β2 blocakade mediated) [20] which need to be explored in future studies. This also contends with the hypoglycaemic effects of Carvedilol reported in some studies [15,16,17]. Whether this hyperglycaemia is severe enough to induce glucotoxicity and worsen the outcomes of the comorbidities in individuals with diabetes/ prediabetic state when Carvedilol is used needs to be analyzed.…”

Section: Discussionmentioning

confidence: 75%

“…At higher doses, it has calcium channel blocking property of moderate potency (blocks L-type voltage gated channels) [11,12] but the effect of this blockade on blood glucose levels is a scantily explored domain [13,14]. Some studies reported beta blocking induced hyperglycaemia contradicting the ideas of its vasodilating property inducing hypoglycaemia by improving insulin sensitivity [15,16,17].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Carvedilol on Blood Glucose Levels In Normal Albino Rats

Suresha

Ashwini²,

Pragathi³

et al. 2013

JCDR

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Background: Carvedilol is a commonly used drug in hypertension, congestive heart failure in diabetics. It has moderate calcium channel blocking property in addition to α1 and non selective β antagonistic activity. Though some studies bring forth the beneficial effects of Carvedilol in cardiovascular comorbidities in diabetes, there is no consensus on its effects on glycaemic levels. Aims:To evaluate the effect of oral Carvedilol administration for 5 days on blood glucose levels in normal albino rats through Oral Glucose Tolerance Test. Material and Methods:Twelve adult albino rats of either sex weighing between 150 -200 g were selected from central animal facility and randomly divided into 2 groups -Control [Distilled water (1ml/rat orally)] and Test (0.8mg/kg body weight orally) and the respective drugs were administered over 5 days. Following overnight fasting, on the fifth day 1 hour after the last dose of the respective drug, OGTT was performed. The CBG (Capillary Blood Glucose) levels were measured at 0 min, glucose (2g/ kg body weight) dissolved in water was administered to all the rats orally. The blood sample from tail vein (obtained by tail snipping) at 60 and 150 minutes were analysed for CBG levels using a standardized glucometer.Statistical Analysis: Data was presented as Mean ± SEM. One way ANOVA, independent samples t-test, non-parametric tests, percentages and cross tabs were used in the analysis of data within the same group and between different groups when required.Results: Carvedilol group showed higher CBG levels at all time intervals of OGTT as compared to the Control group i.e., 0, 60 and 150 minutes, the highest being (103.8±5.029 )mg/dl at 60 minutes and was statistically significant. Carvedilol group however showed lesser inter-interval variation compared to the Control group at the same time intervals respectively but was statistically insignificant. Conclusions:Carvedilol has hyperglycaemic potential when given orally for 5 days in normal albino rats. Though it may be beneficial in diabetics for various comorbid conditions, the glycaemic control may worsen during its use in subjects with prediabetes, diabetes, high risk diabetes.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

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The Effect of Carvedilol on Blood Glucose Levels In Normal Albino Rats

Suresha

Ashwini²,

Pragathi³

et al. 2013

JCDR

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The Glycemic Consequences of Antihypertensive Medications

Barzilay

Davis

2015

Pathophysiology and Pharmacotherapy of Cardiovascular Disease

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The Glycemic Effects of Antihypertensive Medications

Barzilay

Davis

2013

Curr Hypertens Rep

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Older antihypertensive medications are believed to be associated with metabolic disturbances, especially raised glucose levels. Owing to this, many physicians shun their use. Newer antihypertensive medications are metabolically neutral or metabolically favorable; therefore, they are looked upon favorably and are chosen as primary medications for the treatment of hypertension. Here we review the literature on the glucose effects of older and newer antihypertensive medications. We also consider what, if any, impact these metabolic effects have on cardiovascular disease outcomes. We show that the diabetogenic effects of thiazide diuretics and beta blockers are small relative to the glucose effects of angiotensin-converting enzyme inhibitors (ACEIs) and calcium channel blockers, and that over time, the glucose differences between older and newer medications diminish. Importantly, we show that the diabetogenic effects of older antihypertensive medications do not translate into increased cardiovascular disease risk.

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Glucose, Blood Pressure, and Cardiovascular Risk

Cited by 6 publications

References 21 publications

The Effect of Carvedilol on Blood Glucose Levels In Normal Albino Rats

The Effect of Carvedilol on Blood Glucose Levels In Normal Albino Rats

The Glycemic Consequences of Antihypertensive Medications

The Glycemic Effects of Antihypertensive Medications

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