Glucose attenuates the effect of combined muscarinic-nicotinic receptor blockade on spontaneous alternation

Ragozzino, Michael E.; Arankowsky‐Sandoval, Gloria; Gold, Paul E.

doi:10.1016/0014-2999(94)90612-2

Cited by 34 publications

(19 citation statements)

References 29 publications

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“…As previously reported (Stone et al, 1991;Ragozzino et al, 1994;Hiramatsu and Inoue, 2000), scopolamine severely impaired spontaneous alternation in young mice. SIB-1553A was able to reverse this working memory deficit in a dose-dependent manner, and to a similar degree as nicotine.…”

Section: Discussionsupporting

confidence: 86%

“…This sequential procedure relies on working memory since the ability to alternate requires that the subject retain specific information, which varies from trial to trial. It is also sensitive to various manipulations (ie delay intervals, increased number of trials) and pharmacological treatments affecting memory processes (Tako et al, 1988;Ragozzino et al, 1994;Krazem et al, 2001;Stefani and Gold, 2001). …”

Section: Cognitive Studiesmentioning

confidence: 99%

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Cognitive Enhancing Properties and Tolerability of Cholinergic Agents in Mice: A Comparative Study of Nicotine, Donepezil, and SIB-1553A, a Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors

Bontempi¹,

Whelan²,

Risbrough³

et al. 2003

Neuropsychopharmacol

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Several studies have demonstrated the importance of nicotinic mechanisms in the pathophysiology of neurodegenerative and cognitive disorders, warranting the search and development of novel nicotinic ligands as potential therapeutic agents. The present study was designed to assess whether the subtype-selective nicotinic acetylcholine receptor (nAChR) ligand SIB-1553A [( 7 )-4-{[2-(1-methyl-2-pyrrolidinyl)ethyl]thio}phenol hydrochloride], with predominant agonist activity at b4 subunit-containing human nAChRs, and no activity at muscle nAChR subtypes, could enhance cognitive performance in rodents with a more desirable safety/tolerability profile as compared to the nonselective prototypic nAChR ligand nicotine. SIB-1553A was equi-efficacious to nicotine in improving working memory performance in scopolamine-treated mice as measured by increased alternation in a T-maze, and was more efficacious than nicotine in improving the baseline cognitive performance of aged mice. This effect on working memory was confirmed in a delayed nonmatching to place task using the eight-arm radial maze. SIB-1553A produced dose-dependent side effects (ie motor deficits and seizures), although these effects were observed at doses 12 to 640-fold above those required to increase cognitive performance. Overall, SIB-1553A was significantly less potent than nicotine in eliciting these undesirable effects. Thus, the subtype-selective profile of SIB-1553A appears to translate into a more efficacious and better tolerated nAChR ligand as compared to nicotine. In the present studies, cognitive enhancement induced by SIB-1553A was similar in magnitude to that produced by the clinically efficacious acetylcholinesterase inhibitor donepezil. Taken together, the present data confirm the importance of nAChR subtypes in modulating cognitive processes, and suggest that activation of nAChR subtypes by selective nAChR ligands may be a viable approach to enhance cognitive performance.

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Section: Discussionsupporting

confidence: 86%

Section: Cognitive Studiesmentioning

confidence: 99%

Cognitive Enhancing Properties and Tolerability of Cholinergic Agents in Mice: A Comparative Study of Nicotine, Donepezil, and SIB-1553A, a Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors

Bontempi¹,

Whelan²,

Risbrough³

et al. 2003

Neuropsychopharmacol

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“…Previous findings indicate that injections of glucose and other memory-enhancing treatments do not increase spontaneous alternation performance in a Y-maze, although glucose attenuates deficits produced by several drug treatments (13,14,18,19). Therefore, results obtained with the four-arm cross maze provide, to our knowledge, the first demonstration that glucose itself enhances spontaneous alternation performance and that glucose itself enhances memory in a nonappetitive and nonaversive task.…”

mentioning

confidence: 56%

“…For example, glucose attenuates spontaneous alternation deficits produced by cholinergic antagonists on a Y-maze, although glucose administration does not itself enhance performance on this task (18,19). Glucose also reduces hyperactivity and paradoxical sleep deficits produced by muscarinic cholinergic antagonists (20,21).…”

mentioning

confidence: 99%

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Hippocampal acetylcholine release during memory testing in rats: augmentation by glucose.

Ragozzino

Unick

Gold

1996

Proc. Natl. Acad. Sci. U.S.A.

291

190

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Several lines of evidence indicate that a modest increase in circulating glucose levels enhances memory. One mechanism underlying glucose effects on memory may be an increase in acetylcholine (ACh) release. The present experiment determined whether enhancement of spontaneous alternation performance by systemic glucose treatment is related to an increase in hippocampal ACh output. Samples of extracellular ACh were assessed at 12-min intervals using in vivo microdialysis with HPLC-EC. Twenty-four minutes after an intraperitoneal injection of saline or glucose (100, 250, or 1000 mg/kg), rats were tested in a four-arm cross maze for spontaneous alternation behavior combined with microdialysis collection. Glucose at 250 mg/kg, but not 100 or 1000 mg/kg, produced an increase in spontaneous alternation scores (69.5%) and ACh output (121.5% versus baseline) compared to alternation scores (44.7%) and ACh output (58.9%o versus baseline) of saline controls. The glucose-induced increase in alternation scores and ACh output was not secondary to changes in locomotor activity. Saline and glucose (100-1000 mg/kg) treatment had no effect on hippocampal ACh output when rats remained in the holding chamber. These findings suggest that glucose may enhance memory by directly or indirectly increasing the release ofACh. The results also indicate that hippocampal ACh release is increased in rats performing a spatial task. Moreover, because glucose enhanced ACh output only during behavioral testing, circulating glucose may modulate ACh release only under conditions in which cholinergic cells are activated.

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Pretest administration of glucose attenuates infantile amnesia for passive avoidance conditioning in rats

Flint

Riccio

1997

Dev. Psychobiol.

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Glucose attenuates the effect of combined muscarinic-nicotinic receptor blockade on spontaneous alternation

Cited by 34 publications

References 29 publications

Cognitive Enhancing Properties and Tolerability of Cholinergic Agents in Mice: A Comparative Study of Nicotine, Donepezil, and SIB-1553A, a Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors

Cognitive Enhancing Properties and Tolerability of Cholinergic Agents in Mice: A Comparative Study of Nicotine, Donepezil, and SIB-1553A, a Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors

Hippocampal acetylcholine release during memory testing in rats: augmentation by glucose.

Pretest administration of glucose attenuates infantile amnesia for passive avoidance conditioning in rats

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