Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing

Construction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing

“…Biocompatibility is an important factor for the safe application of hydrogels in biomedicine [ 42 ]. As shown in Fig.…”

Recent advances in responsive hydrogels for diabetic wound healing

“…(C) The design strategy of glucose and MMP-9 dual-responsive shape self-adaptive hydrogels for treating chronic diabetic wound (Reproduced with permission of Ref. [ 139 ]). …”

“…To address this issue, Zhou et al. [ 139 ] fabricated a hydrogel with temperature-sensitive shape-adaptive behaviour to promote diabetic wound healing ( Fig. 7 C).…”

Construction of multifunctional wound dressings with their application in chronic wound treatment

“…Zhu et al fabricated a smart multifunctional hydrogel by embedding insulin and gelatin microspheres containing celecoxib (GMs@Cel) into hydrogels based on PVA and phenylboronic acid-grafted chitosan (CS-BA). 141 The hydrogel was able to release insulin and celecoxib in response to high glucose concentrations and MMP-9 at diabetic chronic wound sites. The multifunctional hydrogel could inhibit inflammatory response and regulate the local high level of glucose and MMP-9, thereby effectively promoting wound healing.…”