Glucose 6-phosphate dehydrogenase in rainbow trout

Cederbaum, Stephen D.; Yoshida, Akira

doi:10.1007/bf00484764

Cited by 11 publications

(3 citation statements)

References 26 publications

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“…The genetic interpretation remains obscure due to a rather poor resolution. A single locus hypothesis is presented also for rainbow trout with a post-translational modification responsible for the complexity of banding patterns (CEDERBAUM and YOSHIDA 1976). On the contrary, two or even three loci have been reported for some other salmonid species (LYNCH and VYSE 1979;DEHRING et al 1981).…”

Section: Pgm-l(93)mentioning

confidence: 97%

Electrophoretic expression of genetic variation and duplicate gene activity in vendace, Coregonus albula (Salmonidae)

Vuorinen

2008

Hereditas

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Sixteen isozyme systems were examined by starch gel electrophoresis in vendace, Coregonus albula L. Samples of muscle and liver were analysed from over 2000 fish representing 31 populations. A total of 41 loci were identified. Out of these, 33 appeared suitable for population genetic studies. Polymorphism was observed at 24 loci, of which 17 are described for the first time in vendace. In addition, new alleles are reported for four previously known loci. The average heterozygosity per individual per locus is 7.9%, and 42% of the loci are polymorphic. These values are relatively high for a salmonid. There is extensive genetic heterogeneity among populations. The variability patterns showed that 58% of vendace genes have retained duplicate gene expression. This was due to liver specific Gpi‐3, 4 and Me‐3, 4, which both were expressed as duplicates. In previous studies a single locus has been found coding for these enzymes in the liver‐specific zone of salmonids. The results throw light on salmonid evolution and management of vendace populations.

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Section: Pgm-l(93)mentioning

confidence: 97%

Electrophoretic expression of genetic variation and duplicate gene activity in vendace, Coregonus albula (Salmonidae)

Vuorinen

2008

Hereditas

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“…(1973) found three zones in polyacrylamide gels from liver extracts of river and sea trout. Cederbaum & Yoshida (1976) report various regions with several bands in starch gel. They postulate two alleles of G-6-PD at one locus.…”

Section: Alkaline Phosphatase ( a K P ) (Fig 2 )mentioning

confidence: 99%

Biochemical polymorphisms in muscle and liver extracts and in the serum of the rainbow trout Salmo gairdneri

Diebig

Meyer

Glodek

1979

Animal Blood Groups and Biochemical Genetics

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The frequency of polymorphic phenotypes determined by starch gel electrophoresis from six enzyme systems was investigated on 664 rainbow trout (stock I) originating equally from six full-sib families. The enzyme systems studied were CA, AKP, G-6-PD, SOD, AEP, and 6-PGD.On material deriving from six parental matings totalling 212 offspring (stock 11) the mode of inheritance of the first four enzymes (AEP and 6-PGD were not polymorphic) and the additional systems IDH, PGM, Alb, and Psta, not analysed in stock I, were investigated.The G-6-PD system showed no polymorphism in the family material. The CA, PGM, Al.b, and Psta systems were easily identifiable. Their mode of inheritance with two alleles each can be considered as proven. For SOD three alleles, in four out of six possible progeny types, were found, for which the postulated mode of inheritance was confirmed.For IDH the mode of inheritance found by Allendorff & Utter (1973) was confirmed. This pattern shows two disomic gene loci, one of which is monomorphic, while the other carries four different alleles.The number of alleles and their mode of inheritance for the AEP system, which was not clearly identifiable, could not be elucidated.

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“…Other NADPH‐producing enzymes, such as NADP‐dependent isocitrate dehydrogenase and NADP‐dependent malate dehydrogenase, are usually of minor importance in NADPH production, which is also the case in flounder liver [69]. Hexose‐6‐phosphate dehydrogenase in the endoplasmic reticulum [72,73] provides maximally 20 to 30% of NADPH in the liver of fish [74] needed for CYP450 reactions.…”

Section: Introductionmentioning

confidence: 99%

Reduced nicotinamide adenine dinucleotide phosphate and the higher incidence of pollution‐induced liver cancer in female flounder

Köehler

Noorden

2003

Enviro Toxic and Chemistry

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In biological effect monitoring programs, induction of biotransformation and detoxification enzymes is used as a biomarker for pollution. Yet sex differences are usually neglected in the availability of reduction equivalents needed in these metabolic pathways and may affect biomarker responses. For example, female flounder have a threefold higher incidence of macroscopic liver nodules than males of the same age class in polluted environments of the North Sea that progress toward carcinomas, whereas tumors in males virtually never develop into cancer. Evidence is presented in this review that NADPH plays a significant role in this sex-related response to xenobiotics in liver of flounder. The NADPH is needed for biosynthesis, particularly of lipids and lipoproteins, and detoxification processes such as one-electron and two-electron biotransformation and conjugation and, therefore, its availability as substrate determines biomarker responses. Biotransformation of xenobiotics is more strongly induced and conjugation processes are less affected in male flounder liver during exposure. In female liver, NADPH is required for production of the yolk precursor protein vitellogenin for oocyte production. The latter process has a higher priority than the NADPH-requiring detoxification processes because reproductive success is more relevant in evolutionary perspectives than the survival of the individual female. The data reviewed here suggest that these sex-related differences in NADPH metabolism are a major cause of the higher incidence of liver cancer in female flounder in polluted environments.

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Glucose 6-phosphate dehydrogenase in rainbow trout

Cited by 11 publications

References 26 publications

Electrophoretic expression of genetic variation and duplicate gene activity in vendace, Coregonus albula (Salmonidae)

Electrophoretic expression of genetic variation and duplicate gene activity in vendace, Coregonus albula (Salmonidae)

Biochemical polymorphisms in muscle and liver extracts and in the serum of the rainbow trout Salmo gairdneri

Reduced nicotinamide adenine dinucleotide phosphate and the higher incidence of pollution‐induced liver cancer in female flounder

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