Glucose-6-phosphate dehydrogenase deficient variants are associated with reduced susceptibility to malaria in the Brazilian Amazon

Santana, Marli Stela; Monteiro, Wuelton Marcelo; Siqueira, André Machado; Costa, Mônica F.; Sampaio, Vanderson de Souza; Lacerda, Marcus Vinícius Guimarães; Alecrim, Maria G. C.

doi:10.1093/trstmh/trt015

Cited by 45 publications

(49 citation statements)

References 32 publications

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“…Only 2 of the 15 genetically identifi ed individuals were self-identifi ed as African descendants, a result that can be explained by the mixing that has occurred among local populations. Of these carriers, 60% (9/15) had experienced up to 3 previous episodes of malaria during their lifetime, whereas 33% (5/15) had never presented with a previous episode of malaria, a result similar to that obtained in previous studies (26) (33) (37) . Ten participants had a positive diagnosis of vivax malaria at the time of blood collection.…”

Section: Discussionsupporting

confidence: 86%

Validation of the rapid test Carestart(tm) G6PD among malaria vivax-infected subjects in the Brazilian Amazon

Brito

Peixoto

Almeida

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Section: Discussionsupporting

confidence: 86%

Validation of the rapid test Carestart(tm) G6PD among malaria vivax-infected subjects in the Brazilian Amazon

Brito

Peixoto

Almeida

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…FY*B/FY*X and FY*A/FY*X genotypes are associated with low parasite density, which may favorably impact hemoglobin levels (69). Observational studies have shown protection against P. vivax infections conferred by a RBC enzyme (glucose-6-phosphate dehydrogenase) deficiency (70)(71)(72) and an erythrocyte membrane disorder (Southeast Asian ovalocytosis) by a mechanism that is independent of the Duffy antigen (73). On the other hand, thalassemias, which are disorders of globin synthesis, appear to increase the susceptibility to vivax malaria in carrier populations from different geographic regions (74)(75)(76)(77).…”

Section: Overview Of the Major Determinants Of Vivax Anemiamentioning

confidence: 99%

Potential Immune Mechanisms Associated with Anemia in Plasmodium vivax Malaria: a Puzzling Question

et al. 2014

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The pathogenesis of malaria is complex, generating a broad spectrum of clinical manifestations. One of the major complications and concerns in malaria is anemia, which is responsible for considerable morbidity in the developing world, especially in children and pregnant women. Despite its enormous health importance, the immunological mechanisms involved in malaria-induced anemia remain incompletely understood. Plasmodium vivax, one of the causative agents of human malaria, is known to induce a strong inflammatory response with a robust production of immune effectors, including cytokines and antibodies. Therefore, it is possible that the extent of the immune response not only may facilitate the parasite killing but also may provoke severe illness, including anemia. In this review, we consider potential immune effectors and their possible involvement in generating this clinical outcome during P. vivax infections.

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“…1 It has a prevalence of approximately 4.5% among the male population in the Amazon region. 2,3 Diabetes mellitus is a serious public health problem because of its high prevalence, severe morbidity and mortality; it is also widely distributed. Approximately 5.6% of the Brazilian population have been diagnosed with diabetes.…”

Section: Introductionmentioning

confidence: 99%

High Frequency of Diabetes and Impaired Fasting Glucose in Patients with Glucose-6-Phosphate Dehydrogenase Deficiency in the Western Brazilian Amazon

Santana

Monteiro

Costa

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, and it has a significant prevalence in the male population (X chromosome linked). The purpose of this study was to estimate the frequency of impaired fasting glucose and diabetes among G6PD-deficient persons in Manaus, Brazil, an area in the Western Brazilian Amazon to which malaria is endemic. Glucose-6-phosphate dehydrogenasedeficient males had more impaired fasting glucose and diabetes. This feature could be used as a screening tool for G6PD-deficient persons who are unable to use primaquine for the radical cure of Plasmodium vivax malaria.

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Glucose-6-phosphate dehydrogenase deficient variants are associated with reduced susceptibility to malaria in the Brazilian Amazon

Abstract: G6PD enzyme activity was directly related to susceptibility to malaria in the Brazilian Amazon, where P. vivax predominates. Severe G6PDd was associated with considerable higher risk of malaria-related transfusions.

Cited by 45 publications

References 32 publications

Validation of the rapid test Carestart(tm) G6PD among malaria vivax-infected subjects in the Brazilian Amazon

Validation of the rapid test Carestart(tm) G6PD among malaria vivax-infected subjects in the Brazilian Amazon

Potential Immune Mechanisms Associated with Anemia in Plasmodium vivax Malaria: a Puzzling Question

High Frequency of Diabetes and Impaired Fasting Glucose in Patients with Glucose-6-Phosphate Dehydrogenase Deficiency in the Western Brazilian Amazon

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