Glucosamine sulfate reduces experimental osteoarthritis and nociception in rats: association with changes of mitogen-activated protein kinase in chondrocytes

Wen, Zhi‐Hong; Tang, Chi Chieh; Chang, Yu‐Chan; Huang, Shiying; Hsieh, Shih-Peng; Lee, C.-H.; Huang, Guo Shu; Ng, H.-F.; Neoh, Choo-Aun; Hsieh, Chih-Sung; Chen, W.-F.; Jean, Yen-Hsuan

doi:10.1016/j.joca.2010.05.012

Cited by 82 publications

(86 citation statements)

References 46 publications

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“…The ACLT-induced rat model of OA was employed in this study because it is widely used and reproducible in a range of species including the rat [20,21,27,28] . This model mimics trauma-induced OA that develops following sports injuries in humans [27] .…”

Section: Discussionmentioning

confidence: 99%

Morus alba L. Stem Extract Attenuates Pain and Articular Cartilage Damage in the Anterior Cruciate Ligament Transection-Induced Rat Model of Osteoarthritis

Khunakornvichaya

Lekmeechai²,

Pham³

et al. 2016

Pharmacology

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Aim: This study was designed to investigate the anti-nociceptive effect of Morus alba stem extract as well as its cartilage protective effect in the anterior cruciate ligament transection (ACLT)-induced rat model of osteoarthritis (OA). Methods: The anti-nociceptive effect of this plant extract was determined by measuring hind limb weight bearing, while the severity of cartilage damage to the knee joints was evaluated using the modified Mankin grading system. Results: Oral administration of M. alba stem extract (56 and 560 mg/kg) significantly attenuated joint pain as indicated by a significant (p < 0.05) increase in the values of percent weight borne on the operated hind limb for the OA-induced groups that received M. alba stem extract at 56 and 560 mg/kg when compared to those of the vehicle-treated OA-induced group. In addition, a significant improvement in the Mankin score was also observed in rats treated with 560 mg/kg M. alba stem extract, which was in agreement with its pain-relieving effect. Conclusion: The results showed that M. alba stem extract exhibited an anti-nociceptive effect as well as cartilage protection in the ACLT-induced rat model of OA, supporting its potential use as a therapeutic treatment for OA.

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Section: Discussionmentioning

confidence: 99%

Morus alba L. Stem Extract Attenuates Pain and Articular Cartilage Damage in the Anterior Cruciate Ligament Transection-Induced Rat Model of Osteoarthritis

Khunakornvichaya

Lekmeechai²,

Pham³

et al. 2016

Pharmacology

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“…Weight-bearing deficits were assessed as described in our previous publications [44,52]. Rats were placed on an incapacitance tester (Singa Technology Corporation, Taiwan) so that the hind paws were centered on the two force transducers, enabling the weight distribution between the rat's hind limbs to be measured.…”

Section: Weight-bearing Testmentioning

confidence: 99%

The use of the antimicrobial peptide piscidin (PCD)-1 as a novel anti-nociceptive agent

Chen¹,

Huang²,

Liao³

et al. 2015

Biomaterials

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“…В то же время экзоген-ный ГКА не усиливал синтез ХС в культуре хондроцитов че-ловека. В экспериментах на животных лечение ГКА сущест-венно замедляло прогрессирование ОА [32]. Авторы также показали его способность модифицировать ноцицепцию у крыс.…”

Section: медленно действующие симптоматические препаратыunclassified

Osteoarthritis: Key elements in its pathogenesis and current agents for pathogenetic therapy

Olyunin¹,

Никишина²

2017

RJTAO

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Остеоартрит (ОА) -хроническое прогрессирующее за-болевание суставов, сопровождающееся формированием необратимых изменений опорно-двигательного аппарата и развитием функциональной недостаточности. ОА принято рассматривать не как единую нозологическую форму, а ско-рее как группу заболеваний с различными этиологическими факторами и патогенетическими механизмами. У лиц по-жилого возраста хроническая боль, обусловленная ОА, яв-

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Glucosamine sulfate reduces experimental osteoarthritis and nociception in rats: association with changes of mitogen-activated protein kinase in chondrocytes

Abstract: Our results indicate that treatment with oral glucosamine sulfate in a rat OA model (1) attenuates the development of OA, (2) concomitantly reduces nociception, and (3) modulates chondrocyte metabolism, possibly through inhibition of cell p38 and JNK and increase of ERK expression.

Cited by 82 publications

References 46 publications

<b><i>Morus alba</i></b> L. Stem Extract Attenuates Pain and Articular Cartilage Damage in the Anterior Cruciate Ligament Transection-Induced Rat Model of Osteoarthritis

<b><i>Morus alba</i></b> L. Stem Extract Attenuates Pain and Articular Cartilage Damage in the Anterior Cruciate Ligament Transection-Induced Rat Model of Osteoarthritis

The use of the antimicrobial peptide piscidin (PCD)-1 as a novel anti-nociceptive agent

Osteoarthritis: Key elements in its pathogenesis and current agents for pathogenetic therapy

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