&lt;b&gt;&lt;i&gt;Morus alba&lt;/i&gt;&lt;/b&gt; L. Stem Extract Attenuates Pain and Articular Cartilage Damage in the Anterior Cruciate Ligament Transection-Induced Rat Model of Osteoarthritis

Khunakornvichaya, Arada; Lekmeechai, Sujinna; Pham, Phi Phuong; Himakoun, Wanwisa; Pitaksuteepong, Tasana; Morales, Noppawan Phumala; Hemstapat, Ruedee

doi:10.1159/000447973

Cited by 13 publications

(11 citation statements)

References 33 publications

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“…The ARomDe score monitors the quality of life via the measurement of three dimensions, including pain and function recovery and behavior. It is consistent with many previous studies, which generally evaluate the improvement of models and human with knee osteoarthritis via the achievement of pain relief [2,7,14,19,20,26,28,29] and function recovery [1,2,26,27] and emotional behavior [1,19,20,27].…”

Section: Special Issue On "Human Stem Cells and Transplantation": Open supporting

confidence: 90%

Quality of Life of Elderly and Obese Animal Models with Severe Knee Osteoarthritis after a Single Injection of Mesenchymal Stem Cells

Phermthai¹,

Chareancholvanich²

2017

IJST

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Section: Special Issue On "Human Stem Cells and Transplantation": Open supporting

confidence: 90%

Quality of Life of Elderly and Obese Animal Models with Severe Knee Osteoarthritis after a Single Injection of Mesenchymal Stem Cells

Phermthai¹,

Chareancholvanich²

2017

IJST

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“…Various biological activities of MSE have been demonstrated in the previous studies [7][8][9]. However, long-term stability, water solubility and oral absorption of the crude extract were the major limitations to its application.…”

Section: Resultsmentioning

confidence: 99%

“…It was shown to possess a hydrogen-donating ability, hydroxyl radicals quenching ability, superoxide scavenging activity, nitric oxide scavenging activity and iron reducing capacity [8]. It also has been investigated for the anti-nociceptive effect in anterior cruciate ligament transection (ACLT)-induced rat model of osteoarthritis (OA) [9]. Assessment of knee joint pain was performed by determining the change in the hind limb weight distribution between the operated and the non-operated contralateral limb using the hind limb weight bearing tester.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Stability, Release and in Vitro Digestibility of Mulberry Stem Extract Using Microemulsions

Soonthornsit

Hemstapat

Pitaksutheepong

et al. 2017

Int J Pharm Pharm Sci

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Objective: This study was aimed to develop oral microemulsions and to evaluate their ability to enhance stability, release and intestinal digestion of mulberry stem extract (MSE). Methods:The pseudoternary phase diagrams were constructed using caprylic/capric triglyceride (oil), PEG-8 caprylic/capric glycerides (S), polyglyceryl-3 diisostearate (CoS) and an aqueous phase. The effects of S/CoS (Km) ratio and a cosolvent, i.e. polyethene glycol 400 or propylene glycol (PG), were investigated. The optimized formulations were selected and incorporated with MSE. Then, they were then subjected to stability, release and lipolysis studies. The control solution consisted of 50% PG and 50% water. Results:The formation and characteristics of the microemulsions were influenced by Km and cosolvents. The two optimized formulations (F3 and F4) consisted of 10% oil, 70% S/CoS mixture and 20% aqueous phase were chosen. The Km ratios of F3 and F4 were 4:1 and 3:1. The aqueous phase of F3 and F4 was water and water mixed with PG, respectively. These formulations could improve the stability of MSE better than the control solution. The accumulated release of MSE from F3, F4 and the control solution reached 100% while that of unformulated crude extract reached only 70% after 6 h. The lipolysis study showed that MSE incorporated in both F3 and F4 was digested more than double the percentage compared to that of MSE incorporated in the control solution.Conclusion: MSE was successfully developed in microemulsions. They are shown to be promising vehicles for oral delivery of MSE. Further animal trials are suggested.

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“…When mechanical loading is decreased or absent, osteocytes signal osteoclastogenesis indirectly via osteoblasts and subsequently stimulate bone resorption 31,32 . A reduction in mechanical load on the OA leg, which occurred as a result of shifted pattern of weight-bearing away from the OA leg to prevent further joint damage and to alleviate joint pain, was possibly responsible for stimulating osteoclastogenesis and consequently increasing the erosion surface 15,33,34 .…”

Section: Discussionmentioning

confidence: 99%

Knee osteoarthritis in young growing rats is associated with widespread osteopenia and impaired bone mineralization

Namhong

Wongdee

Suntornsaratoon

et al. 2020

Sci Rep

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Osteoarthritis (OA) leads to joint pain from intraarticular inflammation with articular cartilage erosion, deterioration of joint function and abnormal subchondral bone structure. Besides aging, chronic repetitive joint injury is a common risk factor in young individuals. Nevertheless, whether OA is associated with bone loss at other skeletal sites is unclear. Since OA-associated proinflammatory cytokines—some of which are osteoclastogenic factors—are often detected in the circulation, we hypothesized that the injury-induced knee OA could result in widespread osteopenia at bone sites distant to the injured knee. Here we performed anterior cruciate ligament transection (ACLT) to induce knee OA in one limb of female Sprague–Dawley rats and determined bone changes post-OA induction by micro-computed tomography and computer-assisted bone histomorphometry. We found that although OA modestly altered bone density, histomorphometric analyses revealed increases in bone resorption and osteoid production with impaired mineralization. The bone formation rate was also reduced in OA rats. In conclusions, ACLT in young growing rats induced microstructural defects in the trabecular portion of weight-bearing (tibia) and non-weight-bearing bones (L5 vertebra), in part by enhancing bone resorption and suppressing bone formation. This finding supports the increasing concern regarding the repetitive sport-related ACL injuries and the consequent bone loss.

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<b><i>Morus alba</i></b> L. Stem Extract Attenuates Pain and Articular Cartilage Damage in the Anterior Cruciate Ligament Transection-Induced Rat Model of Osteoarthritis

Cited by 13 publications

References 33 publications

Quality of Life of Elderly and Obese Animal Models with Severe Knee Osteoarthritis after a Single Injection of Mesenchymal Stem Cells

Quality of Life of Elderly and Obese Animal Models with Severe Knee Osteoarthritis after a Single Injection of Mesenchymal Stem Cells

Enhancement of Stability, Release and in Vitro Digestibility of Mulberry Stem Extract Using Microemulsions

Knee osteoarthritis in young growing rats is associated with widespread osteopenia and impaired bone mineralization

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