Glucosamine and maltol anchored Zinc(II) complex of COVID-19 health supplement relevance: DFT collaborated spectroscopic formulation with profound biological implications

Mir, Jan Mohammad; Malik, Bashir Ahmad; Khan, Mohd Washid

doi:10.1016/j.jics.2022.100743

Cited by 2 publications

(2 citation statements)

References 45 publications

(48 reference statements)

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“…It is noteworthy that most of the papers available in literature deal with the use of Zn 2+ ions as antiviral agents, rather than ZnO NSs, possibly in combination with other molecules like lactoferrin, heparin, etc. − Zinc ions can penetrate cell walls (especially when driven by ionophores), augmenting the intracellular Zn 2+ concentration and subsequently impairing virus replication . Bhatti and DeLong recently reviewed the antiviral application of different nanomaterials, including ZnO NSs: in that paper, ROS generated through photocatalytic reactions driven by UV–Vis light on ZnO NSs are indicated as the main species responsible for damaging of the viral envelopes, interfering with viral entry and replication …”

Section: Antimicrobial Applicationsmentioning

confidence: 99%

Synthesis and Antimicrobial Applications of ZnO Nanostructures: A Review

Izzi

Sportelli

Torsi

et al. 2023

ACS Appl. Nano Mater.

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ZnO nanostructures (ZnO NSs) are able to provide significant antimicrobial activity, ensuring high biocompatibility, good chemical stability, and low toxicity. Such versatility has led to great success of this nanomaterial for antibacterial, antifungal, and, more recently, antiviral applications. However, methods for the preparation of ZnO NSs must be properly selected for their end use. Moreover, ZnO NSs can also be cytotoxic to some extent. In this context, this review emphasizes some aspects relevant to the preparation as well as to the antimicrobial use of ZnO NSs. In particular, a brief overview of the sol–gel, hydrothermal, biogenic, and electrochemical approaches proposed for their synthesis is presented, highlighting advantages/drawbacks of each route in terms of scalability, simplicity, and efficacy. Next, the application of ZnO NSs in several fields is reported. This is followed by a discussion of the antimicrobial role of ZnO NSs, where antimicrobial mechanisms of action, possible cell resistance, and cytotoxicity of ZnO NSs are highlighted. We also discuss the role of ZnO NSs against different biothreats, such as bacteria and viruses. The future of such nanomaterials in this application field is addressed in the final part.

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Section: Antimicrobial Applicationsmentioning

confidence: 99%

Synthesis and Antimicrobial Applications of ZnO Nanostructures: A Review

Izzi

Sportelli

Torsi

et al. 2023

ACS Appl. Nano Mater.

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“…Thus, two main types of salts viz glucosamine sulfate [(C 6 H 13 NO 5 ) 2 •H 2 SO 4 ] and glucosamine hydrochloride (C 6 H 13 NO 5 •HCl) are widely used for the therapy of osteoarthritic patients. In addition, they are also added in health care products by food enterprises as a nutrient for strengthening muscles and bones [3,4]. Therefore, many families have numerous reservations, and lots were left expired.…”

Section: Introductionmentioning

confidence: 99%

Expired Glucosamine Drugs as Green Corrosion Inhibitors for Carbon Steel in H2SO4 Solution and Synergistic Effect of Glucosamine Molecules with Iodide Ions: Combined Experimental and Theoretical Investigations

et al. 2023

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Glucosamine is a natural drug widely used for treating osteoarthritis and is usually left until it expires, which will cause a waste of resources if treated as garbage. However, its molecule contains many heteroatoms, entitling it to be a potential corrosion inhibitor. In this investigation, the corrosion inhibition activities of two types of expired glucosamine drugs (glucosamine hydrochloride and glucosamine sulfate) on carbon steel were estimated by electrochemical methods in the acidic solution. The results demonstrated that the glucosamine drugs were mixed-type corrosion inhibitors. Glucosamine hydrochloride could inhibit the carbon steel corrosion more significantly than that of sulfuric style at the same glucosamine content, suggesting a possible synergistic effect of glucosamine molecules with halide ions. Then, the co-adsorption behaviors of glucosamine sulfate with iodide ions were studied by experimental research, as well as theoretical investigations. The results indicated that the inhibition effect could be significantly enhanced when the glucosamine drug was utilized in combination with iodide ions. The electronic structures played a critical role in the synergistic inhibition of glucosamine drugs and iodide ions. Neutral molecules could interact with the metallic surface vertically through the amino and carbonyl groups, while protonated molecules were able to adsorb on it in parallel with the help of multiple functional groups. Since glucosamine molecules would be protonated and positively charged in the acidic solution, they were difficult to adsorb on the solid surface with metallic cations. When the iodide ions were presented, they preferentially adsorbed on the carbon steel surface and induced it to be negatively charged. Therefore, protonated glucosamine molecules could adsorb on the metallic surface using iodide ions as a bridge and form a protective film to mitigate the carbon steel corrosion.

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Glucosamine and maltol anchored Zinc(II) complex of COVID-19 health supplement relevance: DFT collaborated spectroscopic formulation with profound biological implications

Cited by 2 publications

References 45 publications

Synthesis and Antimicrobial Applications of ZnO Nanostructures: A Review

Synthesis and Antimicrobial Applications of ZnO Nanostructures: A Review

Expired Glucosamine Drugs as Green Corrosion Inhibitors for Carbon Steel in H2SO4 Solution and Synergistic Effect of Glucosamine Molecules with Iodide Ions: Combined Experimental and Theoretical Investigations

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