2010
DOI: 10.1590/s0100-879x2010007500005
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Glucocorticoids, master modulators of the thymic catecholaminergic system?

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Cited by 5 publications
(7 citation statements)
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“…Effects of catecholamines on T-lymphocyte development may be modulated by glucocorticoids (Pilipovic et al 2010).…”
Section: Catecholaminesmentioning
confidence: 99%
“…Effects of catecholamines on T-lymphocyte development may be modulated by glucocorticoids (Pilipovic et al 2010).…”
Section: Catecholaminesmentioning
confidence: 99%
“…There is an increasing body of evidence supporting the concept of communication between the body's major adaptive systems (nervous, endocrine, and immune) as a complex network, wherein a signaling molecule can arise from multiple sources to act at multiple targets, and in which signaling molecules are connected to one another in multiple ways and at multiple levels. In favor of this concept are findings showing an interplay between GCs and CAs in the tuning of thymopoiesis, 84 and in particular those findings pointing to putative points of intersections and crosstalk between GC and CA signaling (Fig. 1).…”
Section: Discussionmentioning
confidence: 99%
“…At present, there are no data to confirm GCs’ influence on CA bioavailability in the thymus (this research is in progress in our laboratory). However, we have demonstrated that β‐AR blockade with propranolol, a nonselective beta blocker, led to more pronounced effects on T cell development in previously adrenalectomized rats than in control animals 84 . This is consistent with data showing that in vivo coadministration of hydrocortisone (at a concentration that by itself did not alter the cAMP content of the thymus) with the β‐AR agonist isoproterenol induced a rapid, dose‐dependent increase in the mouse thymic cAMP content and enhanced the effects of isoproterenol on thymic atrophy 85 …”
Section: Glucocorticoid–catecholamine Communications In the Thymopoiementioning
confidence: 90%
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