End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology

Dimitrijević, Mirjana; Stanojević, Stanislava; Kuštrimović, Nataša; Leposavić, Gordana

doi:10.1007/s12026-012-8275-9

Cited by 17 publications

(16 citation statements)

References 189 publications

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“…Adrenal weight is often used as an indirect index of cumulative ACTH exposure, as ACTH stimulates adrenal growth (Ulrich-Lai et al 2006). Thymus weight is often used as an indirect index of cumulative glucocorticoid exposure, as glucocorticoids induce thymic shrinkage (Ulrich-Lai et al 2006; Dimitrijevic et al 2012). …”

Section: 0 Materials and Methodsmentioning

confidence: 99%

The obesity-associated transcription factor ETV5 modulates circulating glucocorticoids

Gutiérrez-Aguilar

Thompson

Marchand

et al. 2015

Physiology & Behavior

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The transcription factor E-twenty-six version 5 (ETV5) has been linked with obesity in genome-wide association studies. Moreover, ETV5-deficient mice (knockout; KO) have reduced body weight, lower fat mass, and are resistant to diet-induced obesity, directly linking ETV5 to the regulation of energy balance and metabolism. ETV5 is expressed in hypothalamic brain regions that regulate both metabolism and HPA axis activity, suggesting that ETV5 may also modulate HPA axis function. In order to test this possibility, plasma corticosterone levels were measured in ETV5 KO and wildtype (WT) mice before (pre-stress) and after (post-stress) a mild stressor (intraperitoneal injection). ETV5 deficiency increased both pre- and post-stress plasma corticosterone, suggesting that loss of ETV5 elevated glucocorticoid tone. Consistent with this idea, ETV5 KO mice have reduced thymus weight, suggestive of increased glucocorticoid-induced thymic involution. ETV5 deficiency also decreased the mRNA expression of glucocorticoid receptor (GR), mineralocorticoid receptor (MR), and vasopressin receptor 1A in the hypothalamus, without altering vasopressin, corticotropin-releasing hormone, or oxytocin mRNA expression. In order to test whether reduced MR and GR expression affected glucocorticoid negative feedback, a dexamethasone suppression test was performed. Dexamethasone reduced plasma corticosterone in both ETV5 KO and WT mice, suggesting that glucocorticoid negative feedback was unaltered by ETV5 deficiency. In summary, these data suggest that the obesity-associated transcription factor ETV5 normally acts to diminish circulating glucocorticoids. This might occur directly via ETV5 actions on HPA-regulatory brain circuitry, and/or indirectly via ETV5-induced alterations in metabolic factors that then influence the HPA axis.

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Section: 0 Materials and Methodsmentioning

confidence: 99%

The obesity-associated transcription factor ETV5 modulates circulating glucocorticoids

Gutiérrez-Aguilar

Thompson

Marchand

et al. 2015

Physiology & Behavior

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“…Обнаружено, что они способны модулировать со-зревание лимфоцитов и активность определенных типов иммунных клеток [25].…”

Section: тимические процессы контролируемые гормонами и нейропептидамиunclassified

“…М. Dimitrijevic с соавт. [25] показали влияние катехо-ламинов (Catecholamines, CAs) и глюкокортикоидов (Glucocorticoids, GCs) на селекцию тимоцитов. Было продемонстрировано также участие катехоламинов в ре-гуляции развития в тимусе Т-регуляторных клеток (Tregs).…”

Section: особенности нейроэндокринно-иммунных взаимодействий при старunclassified

“…Было продемонстрировано также участие катехоламинов в ре-гуляции развития в тимусе Т-регуляторных клеток (Tregs). Авторы отмечают влияние сложных взаимодействий меж-ду GCs, CAs и нейропептидом Y в регуляции функций макрофагов и их значение в патогенезе аутоиммунных воспалительных заболеваний [25].…”

Section: особенности нейроэндокринно-иммунных взаимодействий при старunclassified

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Neuropeptides, Cytokines and Thymus Peptides as Effectors of Interactions Between Thymus and Neuroendocrine System

Zimina

et al. 2015

Annals RAMS

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The review presents data on mutual influence of nervous system and thymus, realized through the neuroendocrine-immune interactions. The presence of adrenergic and peptidergic nerves in thymus creates conditions for implementation of the effect of neuropeptides secreted by them. These neuropeptides induce activation of thymus cells receptors and influence on the main processes in thymus, including T-lymphocyte maturation, cytokine and hormones production. In turn, thymus peptides and/or cytokines, controlled by them, enter the brain and exert influence on neuronal function, which creates the basis for changes of behavior and homeostasis maintenance in response to infection. Ageing and some infectious, autoimmune, neurodegenerative and cancer diseases are accompanied by distortion of interactions between thymus and central nervous system. Mechanisms of signaling pathways, which determine these interactions, are not revealed yet, and their understanding will promote the development of effective therapeutic strategies.

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“…The excessive psychological and emotional stress has negatively affected both mental and physical health conditions [1]. Stress can directly evoke dysfunctions of brain activity, immune system, cardio-vascular, neuroendocrine, and central nervous and sympathetic nervous systems via hypothalamus-pituitary-adrenal (HPA) axis activation [2], [3]. Therefore, excessive and uncontrolled psycho-emotional stress is closely linked to the various spectrums of disorders, such as depression, anxiety, concentration disorders, cancer recurrence, cardiovascular diseases, and chronic fatigue syndrome [4]–[6].…”

Section: Introductionmentioning

confidence: 99%

Ethanolic Extract of Astragali Radix and Salviae Radix Prohibits Oxidative Brain Injury by Psycho-Emotional Stress in Whisker Removal Rat Model

et al. 2014

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Myelophil, an ethanolic extract of Astragali Radix and Salviae Radix, has been clinically used to treat chronic fatigue and stress related disorders in South Korea. In this study, we investigated the protective effects of Myelophil on a whisker removal-induced psycho-emotional stress model. SD rats were subjected to whisker removal after oral administration of Myelophil or ascorbic acid for consecutive 4 days. Whisker removal considerably increased total reactive oxygen species in serum levels as well as cerebral cortex and hippocampal regions in brain tissues. Lipidperoxidation levels were also increased in the cerebral cortex, hippocampus regions, and brain tissue injuries as shown in histopathology and immunohistochemistry. However, Myelophil significantly ameliorated these alterations, and depletion of glutathione contents in both cerebral cortex and hippocampus regions respectively. Serum levels of corticosterone and adrenaline were notably altered after whisker removal stress, whereas these abnormalities were significantly normalized by pre-treatment with Myelophil. The NF-κB was notably activated in both cerebral cortex and hippocampus after whisker removal stress, while it was efficiently blocked by pre-treatment with Myelophil. Myelophil also significantly normalizes alterations of tumor necrosis factor-α, interleukin (IL)-1β, IL-6 and interferon-γ in both gene expressions and protein levels. These results suggest that Myelophil has protective effects on brain damages in psycho-emotional stress, and the underlying mechanisms involve regulation of inflammatory proteins, especially NF-κB modulation.

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End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology

Cited by 17 publications

References 189 publications

The obesity-associated transcription factor ETV5 modulates circulating glucocorticoids

The obesity-associated transcription factor ETV5 modulates circulating glucocorticoids

Neuropeptides, Cytokines and Thymus Peptides as Effectors of Interactions Between Thymus and Neuroendocrine System

Ethanolic Extract of Astragali Radix and Salviae Radix Prohibits Oxidative Brain Injury by Psycho-Emotional Stress in Whisker Removal Rat Model

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