2007
DOI: 10.1016/j.cytogfr.2007.01.005
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Glucocorticoids in the regulation of transcription factors that control cytokine synthesis

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Cited by 102 publications
(90 citation statements)
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References 94 publications
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“…Todo el espectro de albos moleculares explica tanto la pleiotropía como la fuerza antiinflamatoria e inmunomoduladora. Es por eso que al bloquear la síntesis de la citocina IL-5 y el factor estimulante de colonias de granulocitos y macrófagos (GM-CSF), se desencadena la muerte programada de estas células (apoptosis), lo que disminuye la vida media de los eosinófilo, una vez que esta citocina (IL-5) se encarga de la eosinófilopoyesis, causando el aumento de la función de los eosinófilos maduros, así como la degranulación, adherencia y citotoxicidad, prolongando así la sobrevivencia de esa célula (30).…”
Section: Discussionunclassified
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“…Todo el espectro de albos moleculares explica tanto la pleiotropía como la fuerza antiinflamatoria e inmunomoduladora. Es por eso que al bloquear la síntesis de la citocina IL-5 y el factor estimulante de colonias de granulocitos y macrófagos (GM-CSF), se desencadena la muerte programada de estas células (apoptosis), lo que disminuye la vida media de los eosinófilo, una vez que esta citocina (IL-5) se encarga de la eosinófilopoyesis, causando el aumento de la función de los eosinófilos maduros, así como la degranulación, adherencia y citotoxicidad, prolongando así la sobrevivencia de esa célula (30).…”
Section: Discussionunclassified
“…This is why blocking the synthesis of IL-5 cytokine and granulocyte-macrophage colonystimulating factors (GM-CSF) triggers the programmed death of these cells (apoptosis), which decreases the half-life of eosinophil, since cytokine (IL-5) is responsible for eosinophilopoiesis, increasing the function of mature eosinophils as well as degranulation, adhesion and cytotoxicity, thus prolonging the survival of that cell (30).…”
Section: Discussionmentioning
confidence: 99%
“…The repression of NF-κβ will finally inhibit the expression of some cytokines as TNF-α, IL-1, IL-8 (interleukin-8) and ICAM-1 17 . Transrepression between GCs and TFs is reciprocal, and NF-κβ 17 can also repress glucocorticoid receptors; which could, at least in part, induce GC resistance in some patients.…”
Section: Introductionmentioning
confidence: 99%
“…However, the success rate of topical GC ranges from 60.9 to 80% 12,13,16 . The anti-inflammatory property of GCs occurs due to their binding to the glucocorticoid receptor (GR); the GC-GR complex inhibits other TF, such as NF-κβ, a phenomenon known as transrepression 4,[17][18][19] . The repression of NF-κβ will finally inhibit the expression of some cytokines as TNF-α, IL-1, IL-8 (interleukin-8) and ICAM-1 17 .…”
Section: Introductionmentioning
confidence: 99%
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