Glucocorticoids, antioxidants and staurosporine modulate the adherence between monocytes and malaria infected erythrocytes

Goldring, J.P. Dean; Ramoshebi, Lentsha Nathaniel

doi:10.1007/s000110050518

Cited by 6 publications

(3 citation statements)

References 40 publications

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Section: Discussionmentioning

confidence: 99%

“…Cortisol reduces the adherence of infected erythrocytes to monocytes [47]. The cortisol concentration is inversely related to mononuclear cell proliferation in response to malarial antigens in primigravidae from the Gambia [47,12]. Based on these data, our previous demonstration that high cortisol concentrations reduce NK cell cytoxicity against P. falciparuminfected red blood cells [13], and the fact that cortisol down regulates the surface expression of specific cytotoxic receptors on NK cells (natural cytotoxic receptors: NCR) and diminishes the NK-mediated killing of the K562 cell line, a NK-sensitive cell line [48], we hypothesize that cortisol plays an important role in the depression of cell-mediated immunity responsible for the increase susceptibility of primigravidae to malaria.…”

Section: Discussionmentioning

confidence: 99%

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Cortisol and susceptibility to malaria during pregnancy

Bouyou-Akotet

Adegnika

Agnandji

et al. 2005

Microbes and Infection

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cortisol and susceptibility to malaria during pregnancy

Bouyou-Akotet

Adegnika

Agnandji

et al. 2005

Microbes and Infection

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“…The immunotherapy trial was conducted in the presence of quinine. Subsequent to the immunotherapy trial, it has been shown 42 that quinine and other drugs promote a decrease in the expression of host‐cell receptors used as cytoadherence targets and reduce the expression of parasite ligands 43 , 44 . This possible action of quinine is further complicated by malaria infections inducing elevated levels of TNF 45 and IL‐6 46 , which in turn lead to increases in host‐receptor expression 47 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of immunotherapy to reverse sequestration in the treatment of severe Plasmodium falciparum malaria

Goldring

2004

Immunol Cell Biol

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Summary Sequestration and the attachment of Plasmodium falciparum malaria-infected RBC to venous endothelial cells involves parasite-encoded ligands interacting with up to nine host receptors. Antisequestration immunotherapy as an adjunct to quinine did not alter the dynamics of parasite clearance or prove beneficial for the patient. Estimated concentrations of antibody likely to reverse adherence in patients were based on the concentrations of parasite ligands, host receptors and patient equivalents derived from in vitro observations. Calculations presented here indicate that concentrations in excess of a fivefold increase in antibody concentrations used in the immunotherapy trial and equivalent to doubling normal peripheral blood antibody concentrations are anticipated for the successful reversal of sequestration to occur. It is suggested that immunotherapy aimed at either parasite ligands or host receptors to reverse sequestration in the treatment of severe malaria infections is unlikely to be successful given the complexity and number of receptors and ligands and the calculated concentrations of antibodies required.

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Chronic steroid administration does not suppress Plasmodium development and maturation

Rungruang

Kłosek

2007

Parasitol Res

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The objective of this study was to investigate the influence of constant steroid uptake on the Plasmodium yoelii infection rate and parasite maturation. On the animal model, we examined the effect(s) of dexamethasone (Dx), the general drug used for self-treatment by Thai villagers. Ten female ICR mice were subjected to oral administration of 0.5 mg/kg Dx for 40 days, whereas other ten were given drinking water only before P. yoelii 17X (lethal) strain inoculation. Parasite-infected erythrocytes were verified by Giemsa staining under light microscope. The differences of infectivity and maturation were evaluated by Student's t test. Parasitemia was detected in both groups on day 1 and increased until day 6 with similar infection rates. Significant lower numbers of ring, trophozoite, and schizont stages in the control group at the same time compared to Dx-treated mice were noted. The parasite maturation in infected Dx-treated mice appeared faster in comparison to the control. We conclude that the chronic taking of Dx suppresses the host immunity, without any suppressive effects on the parasite development and maturation, and, on the contrary, increases the development and maturation of P. yoelii.

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Glucocorticoids, antioxidants and staurosporine modulate the adherence between monocytes and malaria infected erythrocytes

Abstract: The adherence of malaria infected erythrocytes to monocytes is reduced in response to glucocorticoids (dexamethasone and cortisol), anti-oxidants (probucol and ambroxol), danazol and staurosporine.

Cited by 6 publications

References 40 publications

Cortisol and susceptibility to malaria during pregnancy

Cortisol and susceptibility to malaria during pregnancy

Evaluation of immunotherapy to reverse sequestration in the treatment of severe Plasmodium falciparum malaria

Chronic steroid administration does not suppress Plasmodium development and maturation

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